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Membrane associated complexes : new approach to calciumdynamics modelling

Published online by Cambridge University Press:  20 December 2012

M. Dyzma ,
P. Szopa  and
B. Kaźmierczak
M. Dyzma
Affiliation:
Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw
P. Szopa
Affiliation:
Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw Faculty of Mathematics, Informatics and Mechanics, University of Warsaw
B. Kaźmierczak*
Affiliation:
Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw
*
⋆ Corresponding author. E-mail: [email protected]
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Abstract

Mitochondria are one of the most important organelles determining Ca2+regulatory pathway in the cell. Recent experiments suggested the existence of cytosolicmicrodomains with locally elevated calcium concentration (CMDs) in the nearest vicinity ofthe outer mitochondrial membrane (OMM). These intermediate physical connections betweenendoplasmic reticulum (ER) and mitochodria are called MAM (mitochondria-associated ERmembrane) complexes.

The aim of this paper is to take into account the direct calcium flowfrom ER to mitochondria implied by the existence of MAMs and perform detailed numericalanalysis of the influence of this flow on the type and shape of calcium oscillations.Depending on the permeability of MAMs interface and ER channels, different patterns ofoscillations appear (simple, bursting and chaotic). For some parameters the oscillatorypattern disappear and the system tends to a steady state with extremely high calcium levelin mitochondria, which can be interpreted as a crucial point at the beginning of anapoptotic pathway.

Keywords

Ca2+ signalingmitochodrial Ca2+ transportMAMsthree pool modelbistabilityapoptosis
Type
Research Article
Information
Mathematical Modelling of Natural Phenomena , Volume 7 , Issue 6: Biological oscillations , 2012 , pp. 167 - 186
Copyright
© EDP Sciences, 2012

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