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Host Factors in Viral Life Cycles

Published online by Cambridge University Press:  17 October 2012

G. Pérez-Vilaró ,
J. Jungfleisch ,
V. Saludes ,
N. Scheller ,
M. Giménez-Barcons  and
J. Díez
G. Pérez-Vilaró
Affiliation:
Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain
J. Jungfleisch
Affiliation:
Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain
V. Saludes
Affiliation:
Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain
N. Scheller
Affiliation:
Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain
M. Giménez-Barcons
Affiliation:
Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain
J. Díez*
Affiliation:
Department of Experimental and Health Sciences, Universitat Pompeu Fabra, 08003 Barcelona, Spain
*
⋆ Corresponding author. E-mail: [email protected]
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Abstract

Viruses are obligate intracellular parasites that rely on the host cell for expansion.With the development of global analyses techniques like transcriptomics, proteomics andsiRNA library screening of complete cellular gene sets, a large range of host cell factorshave been discovered that either support or restrict virus growth. Here we summarize someof the recent findings and focus our discussion on the hepatitis C virus and the humanimmunodeficiency virus, two major pathogens that threat global health. The identificationof cellular proteins affecting multiple viruses points to the existence of centralregulation nodes that might be exploited for both, a quantitative description ofhost-virus interactions within single infected cells and the development of novel,broad-spectrum antiviral drugs.

Keywords

host factors as central regulation nodes for quantitative models of viralexpansionidentification of host-virus interactionshepatitis C virushuman immunodeficiency virus
Type
Research Article
Information
Mathematical Modelling of Natural Phenomena , Volume 7 , Issue 5: Immunology , 2012 , pp. 123 - 132
Copyright
© EDP Sciences, 2012

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