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Visual Perceptual Organization Ability in Autopsy-Verified Dementia with Lewy Bodies and Alzheimer’s Disease

Published online by Cambridge University Press:  25 May 2016

Micaela Mitolo ,
Joanne M. Hamilton ,
Kelly M. Landy ,
Lawrence A. Hansen ,
Douglas Galasko ,
Francesca Pazzaglia  and
David P. Salmon
Micaela Mitolo
Affiliation:
Fondazione San Camillo Ospedale - IRCCS, Venice, Italy Department of Neurosciences, University of California San Diego, San Diego, California
Joanne M. Hamilton
Affiliation:
Department of Neurosciences, University of California San Diego, San Diego, California Shiley-Marcos Alzheimer’s Disease Research Center, University of California, San Diego, San Diego, California
Kelly M. Landy
Affiliation:
Department of Neurosciences, University of California San Diego, San Diego, California Shiley-Marcos Alzheimer’s Disease Research Center, University of California, San Diego, San Diego, California
Lawrence A. Hansen
Affiliation:
Department of Neurosciences, University of California San Diego, San Diego, California Shiley-Marcos Alzheimer’s Disease Research Center, University of California, San Diego, San Diego, California Department of Pathology, University of California San Diego, San Diego, California
Douglas Galasko
Affiliation:
Department of Neurosciences, University of California San Diego, San Diego, California Shiley-Marcos Alzheimer’s Disease Research Center, University of California, San Diego, San Diego, California Neurology Service, San Diego Veterans Affairs Medical Center, San Diego, California
Francesca Pazzaglia
Affiliation:
Department of Psychology, University of Padua, Padua, Italy
David P. Salmon*
Affiliation:
Department of Neurosciences, University of California San Diego, San Diego, California Shiley-Marcos Alzheimer’s Disease Research Center, University of California, San Diego, San Diego, California
*
Correspondence and reprint requests to: David P. Salmon, Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0948. E-mail: [email protected]
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Abstract

Objectives: Prominent impairment of visuospatial processing is a feature of dementia with Lewy bodies (DLB), and diagnosis of this impairment may help clinically distinguish DLB from Alzheimer’s disease (AD). The current study compared autopsy-confirmed DLB and AD patients on the Hooper Visual Organization Test (VOT), a test that requires perceptual and mental reorganization of parts of an object into an identifiable whole. The VOT may be particularly sensitive to DLB since it involves integration of visual information processed in separate dorsal and ventral visual “streams”. Methods: Demographically similar DLB (n=28), AD (n=115), and normal control (NC; n=85) participants were compared on the VOT and additional neuropsychological tests. Patient groups did not differ in dementia severity at time of VOT testing. High and Low AD-Braak stage DLB subgroups were compared to examine the influence of concomitant AD pathology on VOT performance. Results: Both patient groups were impaired compared to NC participants. VOT scores of DLB patients were significantly lower than those of AD patients. The diagnostic sensitivity and specificity of the VOT for patients versus controls was good, but marginal for DLB versus AD. High-Braak and low-Braak DLB patients did not differ on the VOT, but High-Braak DLB performed worse than Low-Braak DLB on tests of episodic memory and language. Conclusions: Visual perceptual organization ability is more impaired in DLB than AD but not strongly diagnostic. The disproportionate severity of this visual perceptual deficit in DLB is not related to degree of concomitant AD pathology, which suggests that it might primarily reflect Lewy body pathology. (JINS, 2016, 22, 609–619)

Keywords

Visuoperceptual deficitDementia with Lewy BodiesAlzheimer’s diseaseVisual organizationDementiaVisuospatial deficit
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 22 , Issue 6 , July 2016 , pp. 609 - 619
Copyright
Copyright © The International Neuropsychological Society 2016 

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