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Verbal Fluency in Patients Receiving Bilateral versus Left-Sided Deep Brain Stimulation of the Subthalamic Nucleus for Parkinson's Disease

Published online by Cambridge University Press:  23 January 2012

Rickard L. Sjöberg ,
Elin Lidman ,
Björn Häggström ,
Marwan I. Hariz ,
Jan Linder ,
Anna Fredricks  and
Patric Blomstedt
Rickard L. Sjöberg*
Affiliation:
Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden
Elin Lidman
Affiliation:
Karolinska Institute, Department of Neuroscience Stockholm, Sweden
Björn Häggström
Affiliation:
Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden
Marwan I. Hariz
Affiliation:
Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden UCL Institute of Neurology, Queens Square, London, United Kingdom
Jan Linder
Affiliation:
Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden
Anna Fredricks
Affiliation:
Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden
Patric Blomstedt
Affiliation:
Department of Pharmacology and Clinical Neuroscience, Umeå University, Sweden
*
Correspondence and reprint requests to: Rickard L. Sjöberg, Department of Neurosurgery, University Hospital of Northern Sweden, SE-901 85 Umeå, Sweden. E-mail: [email protected]
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Abstract

The purpose of this study was to investigate the relative effects of unilateral (left-sided) versus bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) on verbal fluency. To do this, 10 Parkinson's disease patients with predominantly bilateral motor symptoms who received bilateral STN DBS were compared with 6 patients suffering from predominantly unilateral symptoms who received STN DBS on the left side only. The results suggest that unilateral STN DBS of the speech dominant hemisphere is associated with significantly less declines in measures of verbal fluency as compared to bilateral stimulation. (JINS, 2012, 18, 606–611)

Keywords

Verbal fluency disordersBasal gangliaPsychological side effectsStereotaxic techniquesFunctional lateralityMovement disorders
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 18 , Issue 3 , May 2012 , pp. 606 - 611
Copyright
Copyright © The International Neuropsychological Society 2012

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References

Alberts, J.L., Hass, C.J., Vitek, J.L., Okun, M.S. (2008). Are two leads always better than one: An emerging case for unilateral deep brain stimulation in Parkinson's Disease. Experimental Neurology, 214, 1–5.CrossRefGoogle ScholarPubMed
Alexander, G.E., DeLong, M.R., Strick, P.L. (1986). Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annual Review of Neuroscience, 9, 357–381.CrossRefGoogle ScholarPubMed
Blomstedt, P., Hariz, M.I. (2006). Are complications less common in deep brain stimulation than in ablative procedures for movement disorders? Stereotactic and Functional Neurosurgery, 84(2–3), 72–81.CrossRefGoogle ScholarPubMed
Claeson, L.-E., Esbjörnsson, E., Tännérus, B.M., Wahlin, M. (1998). Claeson-Dahls test för inlärning och minne: CD-testet (Revised version by Håkan Nyman). Stockholm: Hogrefe Psykologiförlaget AB.Google Scholar
Corrigan, J.D., Hinkeldey, M.S. (1987). Relationships between parts A and B of the Trail Making Test. Journal of Clinical Psychology, 43(4), 402–409.3.0.CO;2-E>CrossRefGoogle Scholar
Gladsjo, J.A., Miller, S.W., Heaton, R.K. (1999). Norms for letter and category fluency: Demographic corrections for age, education and ethnicity. Odessa, TX: Psychological Assessment Resources Inc.Google ScholarPubMed
Gronwall, D.M. (1977). Paced auditory serial-addition task: A measure of recovery from concussion. Perceptual and Motor Skills, 44, 367–373.CrossRefGoogle ScholarPubMed
Heo, J.-H., Lee, K.-M., Paek, S.H., Kim, M.-J., Lee, J.-Y., Kim, J.-Y., Jeon, B.S. (2008). The effects of bilateral subthalamic nucleus deep brain stimulation (STN DBS) on cognition in Parkinson disease. Journal of the Neurological Sciences, 273, 19–24.CrossRefGoogle ScholarPubMed
Howell, D.C. (1992). Statistical methods for psychology (3rd ed.). Belmont CA: Duxbury Press.Google Scholar
Hugdahl, K., Asbjornsen, A. (1994). Dikotisk lyssning med CV-stavelser: Manual. Stockholm: Psykologiförlaget.Google Scholar
Kongs, S.K., Thompson, L.L., Iverson, G.L., Heaton, G.L. (2000). WCST-64, Wisconsin Card Sorting Test-64 Card Version, Professional Manual. Odessa, FL: Psychological Assessment Resources Inc.Google Scholar
Lezak, M.D., Howieson, D.B., Loring, D.W. (2004). Neuropsychological assessment (3rd ed.). New York: Oxford University Press, Inc.Google Scholar
Mikos, A., Bowers, D., Noecker, A.M., McIntyre, C.C., Won, M., Chaturvedi, A., Okun, M.S. (2011). Patient specific analysis of the relationship between the volume of tissue activated during DBS and verbal fluency. Neuroimage, 54, S238–S246.CrossRefGoogle ScholarPubMed
Parsons, T.D., Rogers, S.A., Braaten, A.J., Woods, S.P., Tröster, A. (2006). Cognitive sequelae of subthalamic nucleus deep brain stimulation in Parkinson's disease: A meta analysis. The Lancet Neurology, 5, 578–588.CrossRefGoogle ScholarPubMed
Reitan, R.M. (1958). Validity of the Trail Making test as an indicator of organic brain damage. Perceptual and Motor Skills, 8, 271–276.CrossRefGoogle Scholar
Stuss, D.T., Alexander, M.P., Hamer, L., Palumbo, C., Dempster, R., Binns, M., Izukawa, D. (1998). The effect of focal anterior and posterior brain lesions on verbal fluency. Journal of the International Neuropsychological Society, 4, 265–278.CrossRefGoogle ScholarPubMed
Taba, H.A., Wu, S.S., Foote, K.D., Hass, C.J., Fernandez, H.H., Malaty, I.A., Okun, M.S. (2010). A closer look at unilateral versus bilateral deep brain stimulation: Results of the National Institutes of Health COMPARE cohort. Journal of Neurosurgery, 113, 1224–1229.CrossRefGoogle Scholar
Troyer, A. (2000). Normative data for clustering and switching on verbal fluency tasks. Journal of Clinical and Experimental Neuropsychology, 22, 370–378.CrossRefGoogle ScholarPubMed
Weaver, F.M., Follet, K., Stern, M., Hur, K., Harris, C., Marks, W.J. Jr., Huang, G.D. (2009). Bilateral deep brain stimulation vs best medical therapy for patients with advanced Parkinson disease: A randomized controlled trial. Journal of the American Medical Association, 301, 63–73.CrossRefGoogle ScholarPubMed
Williams, A., Gill, S., Varma, T., Jenkinson, C., Quinn, N., Mitchell, R., Wheatley, K. (2010) Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced Parkinson's disease (PD SURG trial): A randomized open-label trial. The Lancet Neurology, 9, 581–591.CrossRefGoogle Scholar
York, M.K., Dulay, M., Macias, A., Levin, H.S., Grossman, R., Simpson, R., Jankovic, J. (2008). Cognitive declines following bilateral subthalamic nucleus deep brain stimulation for the treatment of Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 79, 789–795.CrossRefGoogle ScholarPubMed