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Verbal Fluency in Parkinson’s Patients with and without Bilateral Deep Brain Stimulation of the Subthalamic Nucleus: A Meta-analysis

Published online by Cambridge University Press:  02 February 2016

Kathryn A. Wyman-Chick Open the ORCID record for Kathryn A. Wyman-Chick [Opens in a new window]
Kathryn A. Wyman-Chick*
Affiliation:
Pacific University, Hillsboro, Oregon
*
Correspondence and reprint requests to: Kathryn A. Wyman-Chick, Pacific University, 190 SE 8th Avenue, Hillsboro, OR 97123. E-mail: [email protected]
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Abstract

Objectives: Patients with Parkinson’s disease often experience significant decline in verbal fluency over time; however, deep brain stimulation of the subthalamic nucleus (STN-DBS) is also associated with post-surgical declines in verbal fluency. The purpose of this study was to determine if Parkinson’s patients who have undergone bilateral STN-DBS have greater impairment in verbal fluency compared to Parkinson’s patients treated by medication only. Methods: A literature search yielded over 140 articles and 10 articles met inclusion criteria. A total of 439 patients with Parkinson’s disease who underwent bilateral STN-DBS and 392 non-surgical patients were included. Cohen’s d, a measure of effect size, was calculated using a random effects model to compare post-treatment verbal fluency in patients with Parkinson’s disease who underwent STN-DBS versus those in the non-surgical comparison group. Results: The random effects model demonstrated a medium effect size for letter fluency (d=−0.47) and a small effect size for category fluency (d=−0.31), indicating individuals with bilateral STN-DBS had significantly worse verbal fluency performance than the non-surgical comparison group. Conclusions: Individuals with Parkinson’s disease who have undergone bilateral STN-DBS experience greater deficits in letter and category verbal fluency compared to a non-surgical group. (JINS, 2016, 22, 478–485)

Keywords

Letter fluencyCategory fluencyDisease comparison groupSTNMovement disordersDBS
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 22 , Issue 4 , April 2016 , pp. 478 - 485
Copyright
Copyright © The International Neuropsychological Society 2016 

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