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Temporal order memory deficits prior to clinical diagnosis in Huntington’s disease

Published online by Cambridge University Press:  01 September 2009

EVA PIROGOVSKY ,
JODY GOLDSTEIN ,
GUERRY PEAVY ,
MARK W. JACOBSON ,
JODY COREY-BLOOM  and
PAUL E. GILBERT
EVA PIROGOVSKY
Affiliation:
SDSU-UCSD Joint Doctoral Program in Clinical Psychology, San Diego, California
JODY GOLDSTEIN
Affiliation:
Department of Neurosciences, UCSD, San Diego, California
GUERRY PEAVY
Affiliation:
Department of Neurosciences, UCSD, San Diego, California Department of Psychiatry, UCSD, San Diego, California
MARK W. JACOBSON
Affiliation:
Department of Psychiatry, UCSD, San Diego, California Veterans Affairs, San Diego Health Care System, San Diego, California
JODY COREY-BLOOM
Affiliation:
Department of Neurosciences, UCSD, San Diego, California
PAUL E. GILBERT*
Affiliation:
SDSU-UCSD Joint Doctoral Program in Clinical Psychology, San Diego, California
*
*Correspondence and reprint requests to: Paul Gilbert, SDSU-UCSD Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, Suite 103, San Diego, CA 92120. E-mail: [email protected]
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Abstract

The current study examined temporal order memory in preclinical Huntington’s disease (pre-HD). Participants were separated into less than 5 years (pre-HD near) and more than 5 years (pre-HD far) from estimated age of clinical diagnosis. Participants completed a temporal order memory task on a computerized radial eight-arm maze. On the study phase of each trial, participants viewed a random sequence of circles appearing one at a time at the end of each arm. On the choice phase, participants viewed two circles at the end of the study phase arms and chose the circle occurring earliest in the sequence. The task involved manipulations of the temporal lag, defined as the number of arms occurring in the sample phase sequence between the two choice phase arms. Research suggests that there is more interference for temporally proximal stimuli relative to temporally distal stimuli. There were no significant differences between the pre-HD far group and controls on the temporal order memory task. The pre-HD near group demonstrated significant impairments relative to the other groups on closer temporal lags, but were normal on the furthest temporal lag. Therefore, temporal order memory declines with increased temporal interference in pre-HD close to estimated diagnosis of HD. (JINS, 2009, 15, 662–670.)

Keywords

NeuropsychologyNeurogenerative diseaseNeuropsychological testCognition disordersBasal ganglia diseasesDementia
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 5 , September 2009 , pp. 662 - 670
Copyright
Copyright © The International Neuropsychological Society 2009

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