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Subjective complaints of cognitive symptoms are related to psychometric findings of memory deficits in patients with HIV-1 infection

Published online by Cambridge University Press:  26 February 2009

Erja Poutiainen  and
Irina Elovaara
Erja Poutiainen
Affiliation:
Departments of Neurology and Psychology, University of Helsinki, Finland
Irina Elovaara
Affiliation:
Department of Neurology, University of Tampere, Finland
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Abstract

Eighty-five subjects at various stages of human immunodeficiency virus (HIV-1) infection and 39 seronegative controls underwent neurological and neuropsychological evaluation to assess the relationship between cognitive test results and subjective complaints (cognitive, affective, motor, and other). The effect of psychiatric disorders on the association between cognitive performance and complaints of the patients was also examined. Patients with symptomatic infection had higher frequency of complaints than subjects at asymptomatic stage. Detailed neuropsychological examination confirmed a strong association between poor verbal memory and cognitive complaints. Poor performance on cognitive speed and flexibility was associated with motor complaints and motor abnormalities. These associations were not explained by psychiatric disorders or elevated depression questionnaire scores. Our observations indicate that, especially in symptomatic HIV-1 infection, cognitive changes reported by patients often reflect “objective” cognitive decline, and may be the earliest signs of HIV-1 associated cognitive disorder. No direct relationship was observed between “subjective” complaints and neuropsychological performance of asymptomatic subjects. Understanding the significance of reported cognitive changes have important therapeutic implications. (JINS, 1996, 2, 219–225.)

Keywords

Cognitive changeSubjective complaintsHIV infection
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 2 , Issue 3 , May 1996 , pp. 219 - 225
Copyright
Copyright © The International Neuropsychological Society 1996

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References

REFERENCES

American Psychiatric Association (1987). Diagnostic and statistical manual of mental disorders (3rd rev. ed.). Washington, DC: American Psychiatric Association Press.Google Scholar
Army Individual Test Battery (1944). Manual of direction and scoring. Washington, DC: Ward Department.Google Scholar
Beason-Hazen, S., Nasrallah, H.A., & Bornstein, R.A. (1994). Selfreports of symptoms and neuropsychological performance in asymptomatic HIV-positive individuals. Journal of Neuropsychiatric and Clinical Neuroscience, 6, 43–49.Google Scholar
Beck, A.T. & Beck, R.W. (1972). Screening depressed patients in family practise. A rapid technic. Postgrad Med, 52, 81–85.Google Scholar
Beck, A.T. & Steer, R.A. (1987). Beck Depression Inventory. Manual. New York: The Psychological Corporation.Google Scholar
Boccellari, A.A., Dilley, J.W., Chambers, D.B., Yingling, C.D., Tauber, M.A., Moss, A.R., & Osmond, D.H. (1993). Immune function and neuropsychological performance in HIV-1-infected homosexual men. Journal of AIDS, 6, 592–601.Google ScholarPubMed
Cassens, G., Wolfe, L., & Zola, M. (1990). The neuropsychology of depressions. Journal of Neuropsychiatry, 2, 202–213.Google ScholarPubMed
Centers for Disease Control (1986). Classification system for human T-lymphotropic virus type III/lymphadenopathy-associated virus infection. Morbidity and Mortality Weekly Report, 35, 334–339.Google Scholar
Centers for Disease Control (1987). Revision of the CDC surveillance case definition for acquired immunodeficiency syndrome. Morbidity and Mortality Weekly Report, 36 (suppl), 1S–16S.Google Scholar
Christensen, A.-L. (1979). Luria's neuropsychological investigation (2nd ed.). Copenhagen: Munksgaard International Publishers Ltd.Google Scholar
Elovaara, I., Nykyri, E., Poutiainen, E., Hokkanen, L., Raininko, R., & Suni, J. (1993). CSF follow-up in HIV-1 infection: Intrathecal production of HIV-specific and unspecific IGG, and beta-2-microglobulin increase with duration of HIV-1 infection. Acta Neurologica Scandinavica, 87, 388–396.CrossRefGoogle ScholarPubMed
Elovaara, I., Poutiainen, E., Raininko, R., Valanne, L., Virta, A., Valle, S.-L., Lähdevirta, J., & Iivanainen, M. (1990). Mild brain atrophy in early HIV infection: The lack of association with cognitive deficits and HIV-specific intrathecal immune response. Journal of Neurological Sciences, 99, 121–136.CrossRefGoogle ScholarPubMed
Grant, I., Atkinson, J.H., Hesselink, J.R., Kennedy, C.J., Richmon, D.D., Spector, S.A., & McCutchan, J.A. (1987). Evidence for early central nervous system involvement in the acquired immunodeficiency virus (AIDS) and other human immunodeficiency virus (HIV) infections. Studies with neuropsychological testing and magnetic resonance imaging. Annals of Internal Medicine, 107, 828–836.CrossRefGoogle ScholarPubMed
Gray, J.W., Dean, R.S., Rattan, G., & Cramer, K.M. (1987). Neuropsychological aspects of primary affective depression. International Journal of Neuroscience, 32, 911–918.CrossRefGoogle ScholarPubMed
Heaton, R.K., Grant, I., Butters, N., White, D.A., Kirson, D., Atkinson, J.H., McCuthan, J.A., Taylor, M.J., Kelly, M.D., Ellis, R.J., Wolfson, T., Velin, R., Marcotte, T.D., Hesselink, J.R., Jernigan, T.L., Chandler, J., Wallace, M., Abramson, I., & HNRC group (1995). The HNRC 500-Neuropsychology of HIV infection at different disease stages. Journal of the International Neuropsychological Society, 1, 231–251.CrossRefGoogle Scholar
Mapou, R.L., Law, W.A., Martin, A., Kampen, D., Salazar, A.M., & Rundell, J.R. (1993). Neuropsychological performance, mood, and complaints of cognitive and motor difficulties in individuals infected with the human immunodeficiency virus. Journal of Neuropsychiatry and Clinical Neurosciences, 5, 86–93.Google ScholarPubMed
Miller, E.N., Selnes, O.A., MeArthur, J.C., Satz, P., Becher, J.T., Cohen, B.A., Sheridan, K., Machado, A.M., van Gorp, W.G., & Visschcr, B. (1990). Neuropsychological performance in HIV- 1-infected homosexual men: The Multicenter AIDS Cohort Study (MACS). Neurology, 40 197–203.CrossRefGoogle Scholar
Navia, B.A. & Price, R.W. (1987). The acquired immunodeficiency syndrome dementia complex as the presenting or sole manifestation of human immunodeficiency virus infection. Archives of Neurology, 44, 65–69.CrossRefGoogle ScholarPubMed
Osterrieth, P.A. (1944). Le test de copie d'une figure complexe. Archieves de Psychologie, 30, 206–356.Google Scholar
Poutiainen, E., Elovaara, I., Raininko, R., Hokkanen, L., Valle, S.-L., Lähdevirta, J., & livanainen, M. (1993). Cognitive performance in HIV-1 infection: Relationship to severity of disease and brain atrophy. Acta Neurologica Scandinavica, 87, 88–94.CrossRefGoogle ScholarPubMed
Ratcliff, G. (1979). Spatial thought, mental rotation and the right cerebral hemisphere. Neuropsychologia, 17, 49–54.CrossRefGoogle ScholarPubMed
Riccio, M., Burgess, A., Hawkins, D., Wilson, B., & Thompson, C. (1990). Neuropsychological and psychiatric changes following treatment of ARC patients with Zidovudine. International Journal of STD and AIDS, 1, 435–437.CrossRefGoogle ScholarPubMed
Schmitt, F.A., Bigley, J.W., McKinnis, R., Logue, P.E., Evans, R.W., Drucker, J.L., & AZT Collaborative Working Group (1988). Neuropsychological outcome of Zidovudine (AZT) treatment of patients with AIDS and AIDS-related complex. New England Journal of Medicine, 319, 1573–1578.CrossRefGoogle Scholar
Selnes, O.A., Miller, E., McArthur, J., Gordon, B., Munoz, A., Sheridan, K., Fox, R., Saah, A.J., & Multicenter AIDS Cohort Study (1990). HIV-1 infection: No evidence of cognitive decline during the asymptomatic stages. Neurology, 40, 204–208.CrossRefGoogle Scholar
Stern, Y., Marder, K., Bell, K., Chen, J., Dooneief, G., Goldstein, S., Mindry, D., Richards, M., Sano, M., Williams, J., Gorman, J., Ehrhardt, A., & Mayeux, R. (1991). Multidisciplinary baseline assessment of homosexual men with and without human immunodeficiency virus infection. III. Neurologic and neuropsychological findings. Archives of General Psychiatry, 48, 131–138.CrossRefGoogle ScholarPubMed
Stroop, J.R. (1935). Studies of interference in serial verbal reactions. Journal of Experimental Psychology, 18, 643–662.CrossRefGoogle Scholar
Valle, S.-L. (1988). Sexually transmitted diseases and the use of condoms in a cohort of homosexual men followed since 1983 in Finland. Scandinavian Journal of Infectious Diseases, 20, 153–161.CrossRefGoogle Scholar
van Gorp, W.G., Satz, P., Hinkin, C., Selnes, O., Miller, E.N., McArthur, J., Cohen, B., Paz, D., & Multicenter AIDS Cohort Study (MACS) (1991). Metacognition in HIV-1 seropositive asymptomatic individuals: Self-ratings versus objective neuropsychological performance. Journal of Clinical and Experimental Neuropsychology, 13, 812–819.CrossRefGoogle Scholar
Wechslcr, D. (1945). A standardized memory scale for clinical use. Journal of Psychology, 19, 87–95.CrossRefGoogle Scholar
Wechslcr, D. (1955). Wechsler Adult Intelligence Scale. Manual. New York: Psychological Corporation.Google Scholar
Wechsler, D. (1971). Wechslerin aikuisten älykkyysasteikko (Wechsler Adult Intelligence Scale) Käisikirja (Manual). Toim, . (Eds.) Fienandt, K. Von, Kalimo, E.. Helsinki: Psykologien Kustannus Oy.Google Scholar
White, D.A., Heaton, R.K., Monsch, A.U., & the HNRC Group. (1995). Neuropsychological studies of asymptomatic human immunodeficiency virus-type-1 infected individuals. Journal of the International Neuropsychological Society, 1, 304–315.CrossRefGoogle ScholarPubMed
Wilkins, J.W., Robertson, K.R., Snyder, C.R., Robertson, W.K., van der Horst, C., & Hall, C.D. (1991). Implications of selfreported cognitive and motor dysfunction in HIV-1 positive patients. American Journal of Psychiatry, 148, 641–643.Google Scholar
World Health Organization (1990). WHO consultation on the neuropsychological aspects of HIV-1 infection. Geneva, January 11–13, 1990.Google Scholar
Yarchoan, R., Berg, G., Brouwers, P., Fischl, M.A., Spizer, A.R., Wichman, A., Grafman, J., Thomas, R.V., Safai, B., Brunetti, A., Perno, C.F., Schmidt, P.J., Larson, S.M., Myers, C.E., & Broder, S. (1987). Response to human immunodeficiency virus associated neurological disease to 3'-azido-3'-deoxythymidine. Lancet, 1, 132–135.CrossRefGoogle Scholar