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Remote memory for public figures in Alzheimer's disease: Relationships to regional cortical and limbic brain volumes

Published online by Cambridge University Press:  05 March 2001

ROSEMARY FAMA ,
PAULA K. SHEAR ,
LAURA MARSH ,
JEROME A. YESAVAGE ,
JARED R. TINKLENBERG ,
KELVIN O. LIM ,
ADOLF PFEFFERBAUM  and
EDITH V. SULLIVAN
ROSEMARY FAMA
Affiliation:
Neuropsychiatry Program, SRI International, Menlo Park, California
PAULA K. SHEAR
Affiliation:
Departments of Psychology and Psychiatry, University of Cincinnati, Cincinnati, Ohio
LAURA MARSH
Affiliation:
Department of Psychiatry, The Johns Hopkins University, Baltimore, Maryland
JEROME A. YESAVAGE
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California Psychiatry Service, VA Palo Alto Health Care System, Palo Alto, California
JARED R. TINKLENBERG
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California Psychiatry Service, VA Palo Alto Health Care System, Palo Alto, California
KELVIN O. LIM
Affiliation:
The Nathan Kline Institute for Psychiatric Research, Orangeburg, New York
ADOLF PFEFFERBAUM
Affiliation:
Neuropsychiatry Program, SRI International, Menlo Park, California
EDITH V. SULLIVAN
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California
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Abstract

This study examined the relationships between regional cortical and hippocampal brain volumes and components of remote memory (recall, recognition, sequencing, and photo naming of presidential candidates) in 13 individuals with Alzheimer's disease (AD). Recognition and sequencing of remote memory for public figures were associated with regional cortical volumes. Specifically, lower recognition and sequencing scores were associated with smaller parietal–occipital cortical volumes; poorer sequencing was also associated with smaller prefrontal cortical volumes. By contrast, poorer anterograde but not remote memory scores were correlated with smaller hippocampal volumes. Within the constraints of the brain regions measured, these findings highlight the importance of the posterior cortical areas for selective remote memory processes and provide support for the dissociation between cortically mediated remote memory and hippocampally mediated anterograde memory. (JINS, 2001, 7, 384–390.)

Keywords

Remote memoryAlzheimer's diseaseMRICortexHippocampus
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 7 , Issue 3 , March 2001 , pp. 384 - 390
Copyright
© 2001 The International Neuropsychological Society

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