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Profiling Social Cognition in Premanifest Huntington's Disease

Published online by Cambridge University Press:  05 May 2021

Kate Turner Open the ORCID record for Kate Turner [Opens in a new window] ,
Danielle Bartlett ,
Sarah A. Grainger ,
Clare Eddy ,
Alvaro Reyes ,
Catarina Kordsachia ,
Mitchell Turner ,
Julie C. Stout ,
Nellie Georgiou-Karistianis  and
Julie D. Henry
...Show all authors
Kate Turner
Affiliation:
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Danielle Bartlett
Affiliation:
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Sarah A. Grainger
Affiliation:
School of Psychology, The University of Queensland, Brisbane, Australia
Clare Eddy
Affiliation:
National Centre for Mental Health, BSMHFT, The Barberry, Birmingham, UK
Alvaro Reyes
Affiliation:
Facultad de Ciencias de la Rehabilitacion, Universidad Andres Bello, Santiago, Chile
Catarina Kordsachia
Affiliation:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia
Mitchell Turner
Affiliation:
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia
Julie C. Stout
Affiliation:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia
Nellie Georgiou-Karistianis
Affiliation:
Turner Institute for Brain and Mental Health, School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Australia
Julie D. Henry
Affiliation:
School of Psychology, The University of Queensland, Brisbane, Australia
Mel Ziman
Affiliation:
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia School of Biomedical Science, University of Western Australia, Crawley, Western Australia, Australia
Travis Cruickshank*
Affiliation:
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia Exercise Medicine Research Institute, School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia Perron Institute for Neurological and Translational Science, Perth, Western Australia, Australia
*
*Correspondence and reprint requests to: Dr Travis Cruickshank, Edith Cowan University, 270 Joondalup Drive, Perth, WA, Australia. Ph: + 61 8 6304 3416. E-mail: [email protected]
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Abstract

Objective:

Discrepancies exist in reports of social cognition deficits in individuals with premanifest Huntington’s disease (HD); however, the reason for this variability has not been investigated. The aims of this study were to (1) evaluate group- and individual-level social cognitive performance and (2) examine intra-individual variability (dispersion) across social cognitive domains in individuals with premanifest HD.

Method:

Theory of mind (ToM), social perception, empathy, and social connectedness were evaluated in 35 individuals with premanifest HD and 29 healthy controls. Cut-off values beneath the median and 1.5 × the interquartile range below the 25th percentile (P25 – 1.5 × IQR) of healthy controls for each variable were established for a profiling method. Dispersion between social cognitive domains was also calculated.

Results:

Compared to healthy controls, individuals with premanifest HD performed worse on all social cognitive domains except empathy. Application of the profiling method revealed a large proportion of people with premanifest HD fell below healthy control median values across ToM (>80%), social perception (>57%), empathy (>54%), and social behaviour (>40%), with a percentage of these individuals displaying more pronounced impairments in empathy (20%) and ToM (22%). Social cognition dispersion did not differ between groups. No significant correlations were found between social cognitive domains and mood, sleep, and neurocognitive outcomes.

Conclusions:

Significant group-level social cognition deficits were observed in the premanifest HD cohort. However, our profiling method showed that only a small percentage of these individuals experienced marked difficulties in social cognition, indicating the importance of individual-level assessments, particularly regarding future personalised treatments.

Keywords

Theory of mindSocial perceptionSocial behaviourEmpathyNeurodegenerative diseaseSocial cognitive dispersion
Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 28 , Issue 3 , March 2022 , pp. 217 - 229
Copyright
Copyright © INS. Published by Cambridge University Press, 2021

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