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Neuropsychological profiles of patients with obsessive-compulsive disorder: early onset versus late onset

Published online by Cambridge University Press:  13 December 2006

SEON HEE HWANG ,
JUN SOO KWON ,
YONG-WOOK SHIN ,
KYUNG JIN LEE ,
YOUNG YOUN KIM  and
MYUNG-SUN KIM
SEON HEE HWANG
Affiliation:
Clinical Research Center, Seoul National University Hospital, Seoul, South Korea Department of Psychology, Sungshin Women's University, Seoul, Korea
JUN SOO KWON
Affiliation:
Clinical Research Center, Seoul National University Hospital, Seoul, South Korea Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea BK21 Life Sciences & Neuroscience Institute, SNU-MRC, Seoul, Korea
YONG-WOOK SHIN
Affiliation:
Clinical Research Center, Seoul National University Hospital, Seoul, South Korea Department of Psychology, Sungshin Women's University, Seoul, Korea
KYUNG JIN LEE
Affiliation:
BK21 Life Sciences & Neuroscience Institute, SNU-MRC, Seoul, Korea
YOUNG YOUN KIM
Affiliation:
Clinical Research Center, Seoul National University Hospital, Seoul, South Korea BK21 Life Sciences & Neuroscience Institute, SNU-MRC, Seoul, Korea
MYUNG-SUN KIM
Affiliation:
Department of Psychology, Sungshin Women's University, Seoul, Korea
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Abstract

In this study, we assess the neuropsychological profiles of both early and late symptom-onset obsessive-compulsive disorder (OCD) patients. The early and late-onset OCD patients are compared to the control group with a series of neuropsychological measurements. The late-onset OCD patients exhibited impaired performance on the immediate and the delayed recall conditions of the Rey-Osterrieth Complex Figure Test (RCFT) and the letter and category fluency of the Controlled Oral Word Association Test (COWA), compared to the normal controls and the early-onset OCD patients. The controls and early-onset OCD patients did not differ on any of the neuropsychological measurements taken in this study. These results suggest that different neurophysiological mechanisms are in play in early and late-onset OCD patients, and age of onset can serve as a potential marker for the subtyping of OCD. (JINS, 2007, 13, 30–37.)

Keywords

Obsessive-compulsive disorder (OCD)SubtypeAge of onsetNeuropsychological functionsEarly-onset OCDLate-onset OCD
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 1 , January 2007 , pp. 30 - 37
Copyright
© 2007 The International Neuropsychological Society

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