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Neural substrates of syntactic mapping treatment: An fMRI study of two cases

Published online by Cambridge University Press:  23 January 2006

CHRISTINA E. WIERENGA ,
LYNN M. MAHER ,
ANNA BACON MOORE ,
KEITH D. WHITE ,
KEITH MCGREGOR ,
DAVID A. SOLTYSIK ,
KYUNG K. PECK ,
KAUNDINYA S. GOPINATH ,
FLORIS SINGLETARY  and
LESLIE J. GONZALEZ-ROTHI
...Show all authors
CHRISTINA E. WIERENGA
Affiliation:
Department of Veterans Affairs Rehabilitation Research and Development, Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, Florida Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida
LYNN M. MAHER
Affiliation:
Department of Veterans Affairs Rehabilitation Research and Development, Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, Florida Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas Baylor College of Medicine, Houston, Texas
ANNA BACON MOORE
Affiliation:
Department of Veterans Affairs Rehabilitation Research and Development, Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, Florida Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida
KEITH D. WHITE
Affiliation:
Department of Veterans Affairs Rehabilitation Research and Development, Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, Florida Department of Psychology, University of Florida, Gainesville, Florida
KEITH MCGREGOR
Affiliation:
Department of Veterans Affairs Rehabilitation Research and Development, Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, Florida Department of Psychology, University of Florida, Gainesville, Florida
DAVID A. SOLTYSIK
Affiliation:
Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida
KYUNG K. PECK
Affiliation:
Department of Radiology, University of Florida, Gainesville, Florida
KAUNDINYA S. GOPINATH
Affiliation:
Department of Nuclear and Radiological Engineering, University of Florida, Gainesville, Florida
FLORIS SINGLETARY
Affiliation:
Department of Veterans Affairs Rehabilitation Research and Development, Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, Florida
LESLIE J. GONZALEZ-ROTHI
Affiliation:
Department of Veterans Affairs Rehabilitation Research and Development, Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, Florida Department of Neurology, University of Florida, Gainesville, Florida
RICHARD W. BRIGGS
Affiliation:
Department of Veterans Affairs Rehabilitation Research and Development, Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, Florida Department of Radiology, University of Florida, Gainesville, Florida
BRUCE CROSSON
Affiliation:
Department of Veterans Affairs Rehabilitation Research and Development, Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, Florida Department of Clinical and Health Psychology, University of Florida, Gainesville, Florida
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Abstract

Two patients (G01, J02) with chronic nonfluent aphasia and sentence production deficits received syntactic mapping treatment to improve sentence production. The patients had dramatically different outcomes in that improved syntax production generalized to nontreatment tasks for G01, but not for JO2. To learn how treatment influenced the neural substrates for syntax production, both patients underwent pre- and posttreatment functional magnetic resonance imaging (fMRI) of sentence generation. G01 showed more robust activity posttreatment than pretreatment in Broca's area; ventral temporal activity decreased slightly from pre- to posttreatment. Comparison of J02's pretreatment and posttreatment images revealed little change, although activity was more diffuse pre- than posttreatment. Findings suggest that for G01, rehabilitation led to engagement of an area (Broca's area) used minimally during the pretreatment scan, whereas for J02, rehabilitation may have led to more efficient use of areas already involved in sentence generation during the pretreatment scan. fMRI findings are discussed in the context of sentence-production outcome and generalization. (JINS, 2006, 12, 132–146.)

Keywords

NeuroplasticityRehabilitationAphasiaFunctional neuroimagingLinguisticsCerebrovascular accident
Type
NEUROBEHAVIORAL GRAND ROUNDS
Information
Journal of the International Neuropsychological Society , Volume 12 , Issue 1 , January 2006 , pp. 132 - 146
Copyright
© 2006 The International Neuropsychological Society

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