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MR spectroscopy in HIV and stimulant dependence

Published online by Cambridge University Press:  01 January 2000

MICHAEL J. TAYLOR ,
OMAR M. ALHASSOON ,
BRIAN C. SCHWEINSBURG ,
JOHN S. VIDEEN  and
IGOR GRANT
MICHAEL J. TAYLOR
Affiliation:
University of California, San Diego VA San Diego Healthcare System
OMAR M. ALHASSOON
Affiliation:
University of California, San Diego San Diego State University
BRIAN C. SCHWEINSBURG
Affiliation:
University of California, San Diego VA San Diego Healthcare System San Diego State University
JOHN S. VIDEEN
Affiliation:
University of California, San Diego VA San Diego Healthcare System
IGOR GRANT
Affiliation:
University of California, San Diego VA San Diego Healthcare System
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Abstract

HIV infection and abuse of central nervous system (CNS) stimulants are both associated with brain damage and dysfunction. CNS stimulant overdose can lead to microinfarction, hemorrhagic lesions, and vasculitis (Bostwick, 1981; Cahill et al., 1981), and may impact frontostriatal systems. Investigations of HIV-infected (HIV+) individuals have demonstrated deficits in attention, speed of information processing, motor functioning, executive functioning, and learning efficiency. These deficits are consistent with frontostriatal involvement (Heaton et al., 1995; Martin, 1994). Given the rise in AIDS cases attributable to drug use at a time when the number of AIDS cases due to sexual transmission is stable or declining, it is critical to determine if drug use, especially CNS stimulants, potentiates HIV-related neuronal injury.

Type
RESEARCH LETTER
Information
Journal of the International Neuropsychological Society , Volume 6 , Issue 1 , January 2000 , pp. 83 - 85
Copyright
© 2000 The International Neuropsychological Society

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