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Long-term effects of high-dose zidovudine treatment on neuropsychological performance in mildly symptomatic HIV-positive patients: Results of a randomized, double-blind, placebo-controlled investigation

Published online by Cambridge University Press:  09 February 2001

ANTOLIN M. LLORENTE ,
WILFRED G. VAN GORP ,
MARTIN J. STERN ,
LANCE GEORGE ,
PAUL SATZ ,
THOMAS D. MARCOTTE ,
GILBERT M. CALVILLO  and
CHARLES H. HINKIN
ANTOLIN M. LLORENTE
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024
WILFRED G. VAN GORP
Affiliation:
Weill Medical College, Cornell University, New York, NY 10065
MARTIN J. STERN
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024
LANCE GEORGE
Affiliation:
Veteran Affairs Medical Center, West Los Angeles, CA
PAUL SATZ
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024
THOMAS D. MARCOTTE
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024
GILBERT M. CALVILLO
Affiliation:
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024
CHARLES H. HINKIN
Affiliation:
Veteran Affairs Medical Center, West Los Angeles, CA
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Abstract

This study examined the treatment outcome of high-dose (1500 mg/day) zidovudine (AZT) on neuropsychological (NP) functioning (Trailmaking Test A & B, WAIS-R Digit Symbol, and Rey Auditory Verbal Learning Test) across a 12-month period in mildly symptomatic HIV-1 seropositive men (n = 46 at entry) enrolled in a randomized, double-blind, placebo-controlled trial (VA Cooperative Studies Program #298). Neither short-term (0–6 months) nor long-term (0–12 months) AZT administration revealed enhancement in NP performance. The results suggest that, although AZT may afford patients prophylactic benefits, protracted high-dose AZT treatment does not improve NP functioning in mildly symptomatic HIV-positive individuals. (JINS, 2001, 7, 27–32)

Keywords

HIV-1Prolonged AZT administrationNeuropsychological outcome
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 7 , Issue 1 , January 2001 , pp. 27 - 32
Copyright
© 2001 The International Neuropsychological Society

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