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Inhibitory control and psychopathology: A meta-analysis of studies using the stop signal task

Published online by Cambridge University Press:  19 August 2010

JONATHAN LIPSZYC  and
RUSSELL SCHACHAR
JONATHAN LIPSZYC
Affiliation:
Department of Psychiatry, Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
RUSSELL SCHACHAR*
Affiliation:
Department of Psychiatry, Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada
*
*Correspondence and reprint requests to: Russell Schachar, Toronto Dominion Bank Financial Group Chair in Child and Adolescent Psychiatry, Neurosciences and Mental Health Program, The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada, M5G 1X8. E-mail: [email protected]
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Abstract

The Stop Signal Task (SST) is a measure that has been used widely to assess response inhibition. We conducted a meta-analysis of studies that examined SST performance in patients with various psychiatric disorders to determine the magnitude and generality of deficient inhibition. A five-item instrument was used to assess the methodological quality of studies. We found medium deficits in stop signal reaction time (SSRT), reflecting the speed of the inhibitory process, for attention-deficit hyperactivity disorder (ADHD) (g = 0.62), obsessive compulsive disorder (OCD) (g = 0.77) and schizophrenia (SCZ) (g = 0.69). SSRT was less impaired or normal for anxiety disorder (ANX), autism, major depressive disorder (MDD), oppositional defiant disorder/conduct disorder (ODD/CD), pathological gambling, reading disability (RD), substance dependence, and Tourette syndrome. We observed a large SSRT deficit for comorbid ADHD + RD (g = 0.82). SSRT was less than moderately impaired for ADHD + ANX and ADHD + ODD/CD. Study quality did not significantly affect SSRT across ADHD studies. This confirms an inhibition deficit in ADHD, and suggests that comorbid ADHD has different effects on inhibition in patients with ANX, ODD/CD, and RD. Further studies are needed to firmly establish an inhibition deficit in OCD and SCZ. (JINS, 2010, 16, 1064–1076.)

Keywords

Attention deficit hyperactivity disorderExecutive controlImpulsive behaviorMeta-analysisObsessive-compulsive disorderSchizophrenia
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 16 , Issue 6 , November 2010 , pp. 1064 - 1076
Copyright
Copyright © The International Neuropsychological Society 2010

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References

REFERENCES

*Albrecht, B., Banaschewski, T., Brandeis, D., Heinrich, H., & Rothenberger, A. (2005). Response inhibition deficits in externalizing child psychiatric disorders: An ERP-study with the Stop-task. Behavioral and Brain Functions, 1, 22. doi: 10.1186/1744-9081-1-22CrossRefGoogle ScholarPubMed
Alderson, R.M., Rapport, M.D., & Kofler, M.J. (2007). Attention-deficit/hyperactivity disorder and behavioral inhibition: A meta-analytic review of the stop-signal paradigm. Journal of Abnormal Child Psychology, 35, 745–758. doi: 10.1007/s10802-007-9131-6Google Scholar
*Alderson, R.M., Rapport, M.D., Sarver, D.E., & Kofler, M.J. (2008). ADHD and behavioral inhibition: A re-examination of the stop-signal task. Journal of Abnormal Child Psychology, 36, 989–998. doi: 10.1007/s10802-008-9230-zCrossRefGoogle ScholarPubMed
American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed.). Washington, DC: American Psychiatric Association.Google Scholar
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.Google Scholar
*Aron, A.R., Dowson, J.H., Sahakian, B.J., & Robbins, T.W. (2003). Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder. Biological Psychiatry, 54, 1465–1468. doi: 10.1016/S0006-3223(03)00609-7Google Scholar
Aron, A.R., Fletcher, P.C., Bullmore, E.T., Sahakian, B.J., & Robbins, T.W. (2003). Stop-signal inhibition disrupted by damage to right inferior frontal gyrus in humans. Nature Neuroscience, 6, 115–116. doi: 10.1038/nn1003CrossRefGoogle ScholarPubMed
*Badcock, J.C., Michie, P.T., Johnson, L., & Combrinck, J. (2002). Acts of control in schizophrenia: Dissociating the components of inhibition. Psychological Medicine, 32, 287–297. doi: 10.1017/S0033291701005128CrossRefGoogle ScholarPubMed
Barkley, R.A. (1997). Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD. Psychological Bulletin, 121, 65–94. doi: 10.1037/0033-2909.121.1.65CrossRefGoogle ScholarPubMed
*Bekker, E.M., Overtoom, C.C., Kenemans, J.L., Kooij, J.J., De Noord, I., Buitelaar, J.K., et al. . (2005). Stopping and changing in adults with ADHD. Psychological Medicine, 35, 807–816. doi: 10.1017/S0033291704003459CrossRefGoogle ScholarPubMed
*Bellgrove, M.A., Chambers, C.D., Vance, A., Hall, N., Karamitsios, M., & Bradshaw, J.L. (2006). Lateralized deficit of response inhibition in early-onset schizophrenia. Psychological Medicine, 36, 495–505. doi: 10.1017/S0033291705006409Google Scholar
*Bidwell, L.C., Willcutt, E.G., Defries, J.C., & Pennington, B.F. (2007). Testing for neuropsychological endophenotypes in siblings discordant for attention-deficit/hyperactivity disorder. Biological Psychiatry, 62, 991–998. doi: 10.1016/j.biopsych.2007.04.003CrossRefGoogle ScholarPubMed
Biederman, J., Newcorn, J., & Sprich, S. (1991). Comorbidity of attention deficit hyperactivity disorder with conduct, depressive, anxiety, and other disorders. American Journal of Psychiatry, 148, 564–577. Retrieved from http://ajp.psychiatryonline.org/Google Scholar
*Bitsakou, P., Psychogiou, L., Thompson, M., & Sonuga-Barke, E.J. (2008). Inhibitory deficits in attention-deficit/hyperactivity disorder are independent of basic processing efficiency and IQ. Journal of Neural Transmission, 115, 261–268. doi: 10.1007/s00702-007-0828-zGoogle Scholar
*Blaskey, L.G., Harris, L.J., & Nigg, J.T. (2008). Are sensation seeking and emotion processing related to or distinct from cognitive control in children with ADHD? Child Neuropsychology, 14, 353–371. doi: 10.1080/09297040701660291CrossRefGoogle ScholarPubMed
Borenstein, M., Hedges, L., Higgins, J., & Rothstein, H. (2005). Comprehensive meta-analysis. Version 2. Englewood NJ: Biostat.Google Scholar
*Brandeis, D., van Leeuwen, T.H., Rubia, K., Vitacco, D., Steger, J., Pascual-Marqui, R.D., et al. . (1998). Neuroelectric mapping reveals precursor of stop failures in children with attention deficits. Behavioural Brain Research, 94, 111–125. doi: 10.1016/S0166-4328(97)00174-5Google Scholar
*Chamberlain, S.R., Del Campo, N., Dowson, J., Muller, U., Clark, L., Robbins, T.W., et al. . (2007). Atomoxetine improved response inhibition in adults with attention deficit/hyperactivity disorder. Biological Psychiatry, 62, 977–984. doi: 10.1016/j.biopsych.2007.03.003Google Scholar
*Chamberlain, S.R., Fineberg, N.A., Blackwell, A.D., Robbins, T.W., & Sahakian, B.J. (2006). Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. American Journal of Psychiatry, 163, 1282–1284. doi: 10.1176/appi.ajp.163.7.1282CrossRefGoogle ScholarPubMed
*Chamberlain, S.R., Fineberg, N.A., Menzies, L.A., Blackwell, A.D., Bullmore, E.T., Robbins, T.W., et al. . (2007). Impaired cognitive flexibility and motor inhibition in unaffected first-degree relatives of patients with obsessive-compulsive disorder. American Journal of Psychiatry, 164, 335–338. doi: 10.1176/appi.ajp.164.2.335Google Scholar
Chevrier, A.D., Noseworthy, M.D., & Schachar, R. (2007). Dissociation of response inhibition and performance monitoring in the stop signal task using event-related fMRI. Human Brain Mapping, 28, 1347–1358. doi: 10.1002/hbm.20355Google Scholar
*Clark, L., Blackwell, A.D., Aron, A.R., Turner, D.C., Dowson, J., Robbins, T.W., et al. . (2007). Association between response inhibition and working memory in adult ADHD: A link to right frontal cortex pathology? Biological Psychiatry, 61, 1395–1401. doi: 10.1016/j.biopsych.2006.07.020CrossRefGoogle ScholarPubMed
Cohen, J. (1992). A power primer. Psychological Bulletin, 112, 155–159. doi: 10.1037/0033-2909.112.1.155CrossRefGoogle ScholarPubMed
*Daugherty, T.K., Quay, H.C., & Ramos, L. (1993). Response perseveration, inhibitory control, and central dopaminergic activity in childhood behavior disorders. Journal of Genetic Psychology, 154, 177–188. Retrieved from http://www.heldref.org/pubs/gnt/about.html.Google Scholar
*de Zeeuw, P., Aarnoudse-Moens, C., Bijlhout, J., Konig, C., Post Uiterweer, A., Papanikolau, A., et al. . (2008). Inhibitory performance, response speed, intraindividual variability, and response accuracy in ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 808–816. doi: 10.1097/CHI.0b013e318172eee9CrossRefGoogle ScholarPubMed
*DeVito, E.E., Blackwell, A.D., Clark, L., Kent, L., Dezsery, A.M., Turner, D.C., et al. . (2009). Methylphenidate improves response inhibition but not reflection-impulsivity in children with attention deficit hyperactivity disorder (ADHD). Psychopharmacology, 202, 531–539. doi: 10.1007/s00213-008-1337-yCrossRefGoogle Scholar
*Dimoska, A., Johnstone, S.J., Barry, R.J., & Clarke, A.R. (2003). Inhibitory motor control in children with attention-deficit/hyperactivity disorder: Event-related potentials in the stop-signal paradigm. Biological Psychiatry, 54, 1345–1354. doi: 10.1016/S0006-3223(03)00703-0Google Scholar
Duval, S., & Tweedie, R. (2000). A nonparametric ‘trim and fill’ method of accounting for publication bias in meta-analysis. Journal of the American Statistical Association, 95, 89–98. doi: 10.2307/2669529Google Scholar
*Enticott, P.G., Ogloff, J.R., & Bradshaw, J.L. (2008). Response inhibition and impulsivity in schizophrenia. Psychiatry Research, 157, 251–254. doi: 10.1016/j.psychres.2007.04.007Google Scholar
*Epstein, J.N., Johnson, D.E., Varia, I.M., & Conners, C.K. (2001). Neuropsychological assessment of response inhibition in adults with ADHD. Journal of Clinical and Experimental Neuropsychology, 23, 362–371. doi: 10.1076/jcen.23.3.362.1186Google Scholar
*Fillmore, M.T., & Rush, C.R. (2002). Impaired inhibitory control of behavior in chronic cocaine users. Drug and Alcohol Dependence, 66, 265–273. doi: 10.1016/S0376-8716(01)00206-XCrossRefGoogle ScholarPubMed
Gershon, J. (2002). A meta-analytic review of gender differences in ADHD. Journal of Attention Disorders, 5, 143–154. doi: 10.1177/108705470200500302CrossRefGoogle ScholarPubMed
*Geurts, H.M., Verte, S., Oosterlaan, J., Roeyers, H., & Sergeant, J.A. (2004). How specific are executive functioning deficits in attention deficit hyperactivity disorder and autism? Journal of Child Psychology and Psychiatry and Allied Disciplines, 45, 836–854. doi: 10.1111/j.1469-7610.2004.00276.xCrossRefGoogle ScholarPubMed
Ghajar, J., & Ivry, R.B. (2008). The predictive brain state: Timing deficiency in traumatic brain injury? Neurorehabilitation and Neural Repair, 22, 217–227. doi: 10.1177/1545968308315600Google Scholar
*Goudriaan, A.E., Oosterlaan, J., de Beurs, E., & van den Brink, W. (2006). Neurocognitive functions in pathological gambling: A comparison with alcohol dependence, Tourette syndrome and normal controls. Addiction, 101, 534–547. doi: 10.1111/j.1360-0443.2006.01380.xCrossRefGoogle ScholarPubMed
*Gupta, R., & Kar, B.R. (2009). Development of attentional processes in ADHD and normal children. Progress in Brain Research, 176, 259–276. doi: 10.1016/S0079-6123(09)17614-8Google Scholar
*Halari, R., Simic, M., Pariante, C.M., Papadopoulos, A., Cleare, A., Brammer, M., et al. . (2009). Reduced activation in lateral prefrontal cortex and anterior cingulate during attention and cognitive control functions in medication-naive adolescents with depression compared to controls. Journal of Child Psychology and Psychiatry and Allied Disciplines, 50, 307–316. doi: 10.1111/j.1469-7610.2008.01972.xCrossRefGoogle ScholarPubMed
Harnishfeger, K.K., & Pope, R.S. (1996). Intending to forget: The development of cognitive inhibition in directed forgetting. Journal of Experimental Child Psychology, 62, 292–315. doi: 10.1006/jecp.1996.0032Google Scholar
Higgins, J.P.T., & Green, S. (Eds.). (2009). Cochrane handbook for systematic reviews of interventions. Version 5.0.2 [updated September 2009]. The Cochrane Collaboration, 2009. Available from www.cochrane-handbook.org.Google Scholar
*Huddy, V.C., Aron, A.R., Harrison, M., Barnes, T.R., Robbins, T.W., & Joyce, E.M. (2008). Impaired conscious and preserved unconscious inhibitory processing in recent onset schizophrenia. Psychological Medicine, 39, 907–916. doi: 10.1017/S0033291708004340CrossRefGoogle ScholarPubMed
*Johannes, S., Wieringa, B.M., Mantey, M., Nager, W., Rada, D., Muller-Vahl, K.R., et al. . (2001). Altered inhibition of motor responses in Tourette Syndrome and Obsessive-Compulsive Disorder. Acta Neurologica Scandinavica, 104, 36–43. doi: 10.1034/j.1600-0404.2001.00308.xCrossRefGoogle ScholarPubMed
*Johnstone, S.J., Barry, R.J., & Clarke, A.R. (2007). Behavioural and ERP indices of response inhibition during a Stop-signal task in children with two subtypes of Attention-Deficit Hyperactivity Disorder. International Journal of Psychophysiology, 66, 37–47. doi: 10.1016/j.ijpsycho.2007.05.011CrossRefGoogle ScholarPubMed
Johnstone, S.J., Dimoska, A., Smith, J.L., Barry, R.J., Pleffer, C.B., Chiswick, D., et al. . (2007). The development of stop-signal and Go/Nogo response inhibition in children aged 7-12 years: Performance and event-related potential indices. International Journal of Psychophysiology, 63, 25–38. doi: 10.1016/j.ijpsycho.2006.07.001CrossRefGoogle ScholarPubMed
*Klein, C., Wendling, K., Huettner, P., Ruder, H., & Peper, M. (2006). Intra-subject variability in attention-deficit hyperactivity disorder. Biological Psychiatry, 60, 1088–1097. doi: 10.1016/j.biopsych.2006.04.003CrossRefGoogle ScholarPubMed
*Konrad, K., Gauggel, S., Manz, A., & Scholl, M. (2000). Inhibitory control in children with traumatic brain injury (TBI) and children with attention deficit/hyperactivity disorder (ADHD). Brain Injury, 14, 859–875. doi: 10.1080/026990500445691Google ScholarPubMed
*Korenblum, C.B., Chen, S.X., Manassis, K., & Schachar, R.J. (2007). Performance monitoring and response inhibition in anxiety disorders with and without comorbid ADHD. Depression and Anxiety, 24, 227–232. doi: 10.1002/da.20237CrossRefGoogle ScholarPubMed
*Krikorian, R., Zimmerman, M.E., & Fleck, D.E. (2004). Inhibitory control in Obsessive-Compulsive Disorder. Brain and Cognition, 54, 257–259. doi: 10.1016/j.bandc.2004.02.038CrossRefGoogle ScholarPubMed
*Kuntsi, J., Oosterlaan, J., & Stevenson, J. (2001). Psychological mechanisms in hyperactivity: I. Response inhibition deficit, working memory impairment, delay aversion, or something else? Journal of Child Psychology and Psychiatry and Allied Disciplines, 42, 199–210. doi: 10.1111/1469-7610.00711Google Scholar
*Lampe, K., Konrad, K., Kroener, S., Fast, K., Kunert, H.J., & Herpertz, S.C. (2007). Neuropsychological and behavioural disinhibition in adult ADHD compared to borderline personality disorder. Psychological Medicine, 37, 1717–1729. doi: 10.1017/S0033291707000517CrossRefGoogle ScholarPubMed
*Lau, M.A., Christensen, B.K., Hawley, L.L., Gemar, M.S., & Segal, Z.V. (2007). Inhibitory deficits for negative information in persons with major depressive disorder. Psychological Medicine, 37, 1249–1259. doi: 10.1017/S0033291707000530CrossRefGoogle ScholarPubMed
*Li, C.S., Huang, C., Yan, P., Bhagwagar, Z., Milivojevic, V., & Sinha, R. (2008). Neural correlates of impulse control during stop signal inhibition in cocaine-dependent men. Neuropsychopharmacology, 33, 1798–1806. doi: 10.1038/sj.npp.1301568Google Scholar
*Li, C.S., Luo, X., Yan, P., Bergquist, K., & Sinha, R. (2009). Altered impulse control in alcohol dependence: Neural measures of stop signal performance. Alcoholism, Clinical and Experimental Research, 33, 740–750. doi: 10.1111/j.1530-0277.2008.00891.xCrossRefGoogle ScholarPubMed
*Li, C.S., Milivojevic, V., Kemp, K., Hong, K., & Sinha, R. (2006). Performance monitoring and stop signal inhibition in abstinent patients with cocaine dependence. Drug and Alcohol Dependence, 85, 205–212. doi: 10.1016/j.drugalcdep.2006.04.008Google Scholar
Lijffijt, M., Kenemans, J.L., Verbaten, M.N., & van Engeland, H. (2005). A meta-analytic review of stopping performance in attention-deficit/hyperactivity disorder: Deficient inhibitory motor control? Journal of Abnormal Psychology, 114, 216–222. doi: 10.1037/0021-843X.114.2.216CrossRefGoogle ScholarPubMed
Light, R.J., Singer, J.D., & Willett, J.B. (1994). The visual presentation and interpretation of meta-analyses. In Cooper, H. & Hedges, L.V., (Eds.), The handbook of research synthesis (pp. 439–454). New York: Russell Sage Foundation.Google Scholar
*Liotti, M., Pliszka, S.R., Perez, R. III, Luus, B., Glahn, D., & Semrud-Clikeman, M. (2007). Electrophysiological correlates of response inhibition in children and adolescents with ADHD: Influence of gender, age, and previous treatment history. Psychophysiology, 44, 936–948. doi: 10.1111/j.1469-8986.2007.00568.xCrossRefGoogle ScholarPubMed
Lipsey, M.W., & Wilson, D.B. (2001). Practical meta-analysis. Thousand Oaks, CA: Sage Publications.Google ScholarPubMed
Logan, G.D., & Burkell, J. (1986). Dependence and independence in responding to double stimulation: A comparison of stop, change, and dual-task paradigms. Journal of Experimental Psychology: Human Perception and Performance, 12, 549–563. doi: 10.1037/0096-1523.12.4.549Google Scholar
Luciano, M., Wright, M., Smith, G.A., Geffen, G.M., Geffen, L.B., & Martin, N.G. (2001). Genetic covariance among measures of information processing speed, working memory, and IQ. Behavior Genetics, 31, 581–592. doi: 10.1023/A:1013397428612CrossRefGoogle ScholarPubMed
*Manassis, K., Tannock, R., & Barbosa, J. (2000). Dichotic listening and response inhibition in children with comorbid anxiety disorders and ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 1152–1159. doi: 10.1097/00004583-200009000-00015CrossRefGoogle Scholar
*Martel, M., Nikolas, M., & Nigg, J.T. (2007). Executive function in adolescents with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 46, 1437–1444. doi: 10.1097/chi.0b013e31814cf953CrossRefGoogle ScholarPubMed
*Marzocchi, G.M., Oosterlaan, J., Zuddas, A., Cavolina, P., Geurts, H., Redigolo, D., et al. . (2008). Contrasting deficits on executive functions between ADHD and reading disabled children. Journal of Child Psychology and Psychiatry and Allied Disciplines, 49, 543–552. doi: 10.1111/j.1469-7610.2007.01859.xGoogle Scholar
*Matthews, S., Simmons, A., Strigo, I., Gianaros, P., Yang, T., & Paulus, M. (2009). Inhibition-related activity in subgenual cingulate is associated with symptom severity in major depression. Psychiatry Research, 172, 1–6. doi: 10.1016/j.pscychresns.2008.08.006CrossRefGoogle ScholarPubMed
*McAlonan, G.M., Cheung, V., Chua, S.E., Oosterlaan, J., Hung, S.F., Tang, C.P., et al. . (2009). Age-related grey matter volume correlates of response inhibition and shifting in attention-deficit hyperactivity disorder. British Journal of Psychiatry, 194, 123–129. doi: 10.1192/bjp.bp.108.051359Google Scholar
*McInerney, R.J., & Kerns, K.A. (2003). Time reproduction in children with ADHD: Motivation matters. Child Neuropsychology, 9, 91–108. doi: 10.1076/chin.9.2.91.14506CrossRefGoogle ScholarPubMed
*Michel, J.A., Kerns, K.A., & Mateer, C.A. (2005). The effect of reinforcement variables on inhibition in children with ADHD. Child Neuropsychology, 11, 295–302. doi: 10.1080/092970490911270CrossRefGoogle ScholarPubMed
*Morein-Zamir, S., Hommersen, P., Johnston, C., & Kingstone, A. (2008). Novel measures of response performance and inhibition in children with ADHD. Journal of Abnormal Child Psychology, 36, 1199–1210. doi: 10.1007/s10802-008-9243-7CrossRefGoogle ScholarPubMed
*Mullane, J.C., & Corkurn, P.V. (2007). The relationship between working memory, inhibition, and performance on the Wisconsin Card Sorting Test in children with and without ADHD. Journal of Psychoeducational Assessment, 25, 211–221. doi: 10.1177/0734282906297627CrossRefGoogle Scholar
*Murphy, P. (2002). Inhibitory control in adults with Attention-Deficit/Hyperactivity Disorder. Journal of Attention Disorders, 6, 1–4. doi: 10.1177/108705470200600101CrossRefGoogle ScholarPubMed
*Nigg, J., Nikolas, M., Friderici, K., Park, L., & Zucker, R.A. (2007). Genotype and neuropsychological response inhibition as resilience promoters for attention-deficit/hyperactivity disorder, oppositional defiant disorder, and conduct disorder under conditions of psychosocial adversity. Development and Psychopathology, 19, 767–786. doi: 10.1017/S0954579407000387CrossRefGoogle ScholarPubMed
*Nigg, J.T. (1999). The ADHD response-inhibition deficit as measured by the stop task: Replication with DSM-IV combined type, extension, and qualification. Journal of Abnormal Child Psychology, 27, 393–402. doi: 10.1023/A:1021980002473CrossRefGoogle ScholarPubMed
*Nigg, J.T., Stavro, G., Ettenhofer, M., Hambrick, D.Z., Miller, T., & Henderson, J.M. (2005). Executive functions and ADHD in adults: Evidence for selective effects on ADHD symptom domains. Journal of Abnormal Psychology, 114, 706–717. doi: 10.1037/0021-843X.114.3.706Google Scholar
Oosterlaan, J., Logan, G.D., & Sergeant, J.A. (1998). Response inhibition in AD/HD, CD, comorbid AD/HD + CD, anxious, and control children: A meta-analysis of studies with the stop task. Journal of Child Psychology and Psychiatry and Allied Disciplines, 39, 411–425. doi: 10.1017/S0021963097002072Google Scholar
*Oosterlaan, J., & Sergeant, J.A. (1996). Inhibition in ADHD, aggressive, and anxious children: A biologically based model of child psychopathology. Journal of Abnormal Child Psychology, 24, 19–36. doi: 10.1007/BF01448371Google Scholar
*Oosterlaan, J., & Sergeant, J.A. (1998). Response inhibition and response re-engagement in attention-deficit/hyperactivity disorder, disruptive, anxious and normal children. Behavioural Brain Research, 94, 33–43. doi: 10.1016/S0166-4328(97)00167-8Google Scholar
*Ossmann, J.M., & Mulligan, N.W. (2003). Inhibition and attention deficit hyperactivity disorder in adults. American Journal of Psychology, 116, 35–50. doi: 10.2307/1423334CrossRefGoogle ScholarPubMed
*Overtoom, C.C., Kenemans, J.L., Verbaten, M.N., Kemner, C., van der Molen, M.W., van Engeland, H., et al. . (2002). Inhibition in children with attention-deficit/hyperactivity disorder: A psychophysiological study of the stop task. Biological Psychiatry, 51, 668–676. doi: 10.1016/S0006-3223(01)01290-2CrossRefGoogle ScholarPubMed
*Ozonoff, S., & Strayer, D.L. (1997). Inhibitory function in nonretarded children with autism. Journal of Autism and Developmental Disorders, 27, 59–77. doi: 10.1023/A:1025821222046CrossRefGoogle ScholarPubMed
Paule, M.G., Rowland, A.S., Ferguson, S.A., Chelonis, J.J., Tannock, R., Swanson, J.M., et al. . (2000). Attention deficit/hyperactivity disorder: Characteristics, interventions and models. Neurotoxicology and Teratology, 22, 631–651. doi: 10.1016/S0892-0362(00)00095-7CrossRefGoogle ScholarPubMed
*Penades, R., Catalan, R., Rubia, K., Andres, S., Salamero, M., & Gasto, C. (2007). Impaired response inhibition in obsessive compulsive disorder. European Psychiatry, 22, 404–410. doi: 10.1016/j.eurpsy.2006.05.001CrossRefGoogle ScholarPubMed
*Pliszka, S.R., Borcherding, S.H., Spratley, K., Leon, S., & Irick, S. (1997). Measuring inhibitory control in children. Journal of Developmental and Behavioral Pediatrics, 18, 254–259. doi: 10.1097/00004703-199708000-00005Google Scholar
*Pliszka, S.R., Glahn, D.C., Semrud-Clikeman, M., Franklin, C., Perez, R. III, Xiong, J., et al. . (2006). Neuroimaging of inhibitory control areas in children with attention deficit hyperactivity disorder who were treatment naive or in long-term treatment. American Journal of Psychiatry, 163, 1052–1060. doi: 10.1176/appi.ajp.163.6.1052Google Scholar
*Pliszka, S.R., Liotti, M., & Woldorff, M.G. (2000). Inhibitory control in children with attention-deficit/hyperactivity disorder: Event-related potentials identify the processing component and timing of an impaired right-frontal response-inhibition mechanism. Biological Psychiatry, 48, 238–246. doi: 10.1016/S0006-3223(00)00890-8Google Scholar
*Purvis, K.L., & Tannock, R. (2000). Phonological processing, not inhibitory control, differentiates ADHD and reading disability. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 485–494. doi: 10.1097/00004583-200004000-00018CrossRefGoogle Scholar
Quay, H.C. (1997). Inhibition and attention deficit hyperactivity disorder. Journal of Abnormal Child Psychology, 25, 7–13. doi: 10.1023/A:1025799122529CrossRefGoogle ScholarPubMed
*Ray Li, C.S., Chang, H.L., Hsu, Y.P., Wang, H.S., & Ko, N.C. (2006). Motor response inhibition in children with Tourette’s disorder. Journal of Neuropsychiatry and Clinical Neurosciences, 18, 417–419. doi: 10.1176/appi.neuropsych.18.3.417CrossRefGoogle ScholarPubMed
*Rodriguez-Jimenez, R., Avila, C., Jimenez-Arriero, M.A., Ponce, G., Monasor, R., Jimenez, M., et al. . (2006). Impulsivity and sustained attention in pathological gamblers: Influence of childhood ADHD history. Journal of Gambling Studies, 22, 451–461. doi: 10.1007/s10899-006-9028-2CrossRefGoogle ScholarPubMed
*Rommelse, N.N., Altink, M.E., Oosterlaan, J., Buschgens, C.J., Buitelaar, J., & Sergeant, J.A. (2008). Support for an independent familial segregation of executive and intelligence endophenotypes in ADHD families. Psychological Medicine, 1–12. doi: 10.1017/S0033291708002869Google Scholar
Rosenthal, R. (1991). Meta-analytic procedures for social research. Beverly Hills, CA: Sage.Google Scholar
Rosenthal, R. (1995). Writing meta-analytic reviews. Psychological Bulletin, 118, 183–192. doi: 10.1037/0033-2909.118.2.183CrossRefGoogle Scholar
*Rubia, K., Halari, R., Smith, A.B., Mohammed, M., Scott, S., Giampietro, V., et al. . (2008). Dissociated functional brain abnormalities of inhibition in boys with pure conduct disorder and in boys with pure attention deficit hyperactivity disorder. American Journal of Psychiatry, 165, 889–897. doi: 10.1176/appi.ajp.2008.07071084CrossRefGoogle ScholarPubMed
*Rubia, K., Oosterlaan, J., Sergeant, J.A., Brandeis, D., & v Leeuwen, T. (1998). Inhibitory dysfunction in hyperactive boys. Behavioural Brain Research, 94, 25–32. doi: 10.1016/S0166-4328(97)00166-6CrossRefGoogle ScholarPubMed
*Rubia, K., Russell, T., Bullmore, E.T., Soni, W., Brammer, M.J., Simmons, A., et al. . (2001). An fMRI study of reduced left prefrontal activation in schizophrenia during normal inhibitory function. Schizophrenia Research, 52, 47–55. doi: 10.1016/S0920-9964(00)00173-0Google Scholar
*Rubia, K., Smith, A., & Taylor, E. (2007). Performance of children with attention deficit hyperactivity disorder (ADHD) on a test battery of impulsiveness. Child Neuropsychology, 13, 276–304. doi: 10.1080/09297040600770761CrossRefGoogle ScholarPubMed
*Rubia, K., Smith, A.B., Brammer, M.J., Toone, B., & Taylor, E. (2005). Abnormal brain activation during inhibition and error detection in medication-naive adolescents with ADHD. American Journal of Psychiatry, 162, 1067–1075. doi: 10.1176/appi.ajp.162.6.1067CrossRefGoogle ScholarPubMed
*Rubia, K., Taylor, E., Smith, A.B., Oksanen, H., Overmeyer, S., & Newman, S. (2001). Neuropsychological analyses of impulsiveness in childhood hyperactivity. British Journal of Psychiatry, 179, 138–143. doi: 10.1192/bjp.179.2.138CrossRefGoogle ScholarPubMed
*Rubio, G., Jimenez, M., Rodriguez-Jimenez, R., Martinez, I., Iribarren, M.M., Jimenez-Arriero, M.A., et al. . (2007). Varieties of impulsivity in males with alcohol dependence: The role of Cluster-B personality disorder. Alcoholism, Clinical and Experimental Research, 31, 1826–1832. doi: 10.1111/j.1530-0277.2007.00506.xGoogle Scholar
*Rucklidge, J.J., & Tannock, R. (2002). Neuropsychological profiles of adolescents with ADHD: Effects of reading difficulties and gender. Journal of Child Psychology and Psychiatry and Allied Disciplines, 43, 988–1003. doi: 10.1111/1469-7610.00227CrossRefGoogle ScholarPubMed
*Schachar, R., Chen, S., Crosbie, J., Goos, L., Ickowicz, A., & Charach, A. (2007). Comparison of the predictive validity of hyperkinetic disorder and attention deficit hyperactivity disorder. Journal of the Canadian Academy of Child and Adolescent Psychiatry, 16, 90–100. Retrieved from http://www.cacap-acpea.org/publications_the_journal.aspx.Google ScholarPubMed
*Schachar, R., & Logan, G.D. (1990). Impulsivity and inhibitory control in normal development and childhood psychopathology. Developmental Psychology, 26, 710–720. doi: 10.1037/0012-1649.26.5.710.Google Scholar
*Schachar, R., Logan, G.D., Robaey, P., Chen, S., Ickowicz, A., & Barr, C. (2007). Restraint and cancellation: Multiple inhibition deficits in attention deficit hyperactivity disorder. Journal of Abnormal Child Psychology, 35, 229–238. doi: 10.1007/s10802-006-9075-2Google Scholar
*Schachar, R., Mota, V.L., Logan, G.D., Tannock, R., & Klim, P. (2000). Confirmation of an inhibitory control deficit in attention-deficit/hyperactivity disorder. Journal of Abnormal Child Psychology, 28, 227–235. doi: 10.1023/A:1005140103162Google Scholar
Schachar, R., Sandberg, S., & Rutter, M. (1986). Agreement between teachers’ ratings and observations of hyperactivity, inattentiveness, and defiance. Journal of Abnormal Child Psychology, 14, 331–345. doi: 10.1007/BF00915450CrossRefGoogle ScholarPubMed
*Schachar, R., & Tannock, R. (1995). Test of four hypotheses for the comorbidity of attention-deficit hyperactivity disorder and conduct disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 34, 639–648. doi: 10.1097/00004583-199505000-00016Google Scholar
*Schachar, R., Tannock, R., Marriott, M., & Logan, G. (1995). Deficient inhibitory control in attention deficit hyperactivity disorder. Journal of Abnormal Child Psychology, 23, 411–437. doi: 10.1007/BF01447206CrossRefGoogle ScholarPubMed
*Schachar, R.J., Chen, S., Logan, G.D., Ornstein, T.J., Crosbie, J., Ickowicz, A., et al. . (2004). Evidence for an error monitoring deficit in attention deficit hyperactivity disorder. Journal of Abnormal Child Psychology, 32, 285–293. doi: 10.1023/B: JACP.0000026142.11217.f2CrossRefGoogle ScholarPubMed
*Schachar, R.J., Crosbie, J., Barr, C.L., Ornstein, T.J., Kennedy, J., Malone, M., et al. . (2005). Inhibition of motor responses in siblings concordant and discordant for attention deficit hyperactivity disorder. American Journal of Psychiatry, 162, 1076–1082. doi: 10.1176/appi.ajp.162.6.1076CrossRefGoogle ScholarPubMed
*Scheres, A., Oosterlaan, J., Geurts, H., Morein-Zamir, S., Meiran, N., Schut, H., et al. . (2004). Executive functioning in boys with ADHD: Primarily an inhibition deficit? Archives of Clinical Neuropsychology, 19, 569–594. doi: 10.1016/j.acn.2003.08.005Google Scholar
*Scheres, A., Oosterlaan, J., & Sergeant, J.A. (2001). Response execution and inhibition in children with AD/HD and other disruptive disorders: The role of behavioural activation. Journal of Child Psychology and Psychiatry and Allied Disciplines, 42, 347–357. doi: 10.1017/S0021963001006898Google Scholar
*Shanahan, M.A., Pennington, B.F., & Willcutt, E.W. (2008). Do motivational incentives reduce the inhibition deficit in ADHD? Developmental Neuropsychology, 33, 137–159. doi: 10.1080/87565640701884238Google Scholar
*Siklos, S., & Kerns, K.A. (2004). Assessing multitasking in children with ADHD using a modified Six Elements Test. Archives of Clinical Neuropsychology, 19, 347–361. doi: 10.1016/S0887-6177(03)00071-4Google Scholar
Slusarek, M., Velling, S., Bunk, D., & Eggers, C. (2001). Motivational effects on inhibitory control in children with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 355–363. doi: 10.1097/00004583-200103000-00016CrossRefGoogle ScholarPubMed
*Solanto, M.V., Abikoff, H., Sonuga-Barke, E., Schachar, R., Logan, G.D., Wigal, T., et al. . (2001). The ecological validity of delay aversion and response inhibition as measures of impulsivity in AD/HD: A supplement to the NIMH multimodal treatment study of AD/HD. Journal of Abnormal Child Psychology, 29, 215–228. doi: 10.1023/A:1010329714819Google Scholar
Solanto, M.V., Gilbert, S.N., Raj, A., Zhu, J., Pope-Boyd, S., Stepak, B., et al. . (2007). Neurocognitive functioning in AD/HD, predominantly inattentive and combined subtypes. Journal of Abnormal Child Psychology, 35, 729–744. doi: 10.1007/s10802-007-9123-6Google Scholar
Suzuki, M., Zhou, S.Y., Takahashi, T., Hagino, H., Kawasaki, Y., Niu, L., et al. . (2005). Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis. Brain, 128(Pt 9), 2109–2122. doi: 10.1093/brain/awh554CrossRefGoogle ScholarPubMed
*Toplak, M.E., Bucciarelli, S.M., Jain, U., & Tannock, R. (2009). Executive functions: Performance-based measures and the behavior rating inventory of executive function (BRIEF) in adolescents with attention deficit/hyperactivity disorder (ADHD). Child Neuropsychology, 15, 53–72. doi: 10.1080/09297040802070929Google Scholar
*Turner, D.C., Clark, L., Dowson, J., Robbins, T.W., & Sahakian, B.J. (2004). Modafinil improves cognition and response inhibition in adult attention-deficit/hyperactivity disorder. Biological Psychiatry, 55, 1031–1040. doi: 10.1016/j.biopsych.2004.02.008CrossRefGoogle ScholarPubMed
*Turner, D.C., Clark, L., Pomarol-Clotet, E., McKenna, P., Robbins, T.W., & Sahakian, B.J. (2004). Modafinil improves cognition and attentional set shifting in patients with chronic schizophrenia. Neuropsychopharmacology, 29, 1363–1373. doi: 10.1038/sj.npp.1300457Google Scholar
*van der Schoot, M., Licht, R., Horsley, T.M., & Sergeant, J.A. (2000). Inhibitory deficits in reading disability depend on subtype: Guessers but not spellers. Child Neuropsychology, 6, 297–312. doi: 10.1076/chin.6.4.297.3139Google Scholar
Verbruggen, F., & Logan, G.D. (2009). Models of response inhibition in the stop-signal and stop-change paradigms. Neuroscience and Biobehavioral Reviews, 33, 647–661. doi: 10.1016/j.neubiorev.2008.08.014CrossRefGoogle ScholarPubMed
*Verte, S., Geurts, H.M., Roeyers, H., Oosterlaan, J., & Sergeant, J.A. (2005). Executive functioning in children with autism and Tourette syndrome. Development and Psychopathology, 17, 415–445. doi: 10.1017/S0954579405050200CrossRefGoogle ScholarPubMed
*Vink, M., Ramsey, N.F., Raemaekers, M., & Kahn, R.S. (2006). Striatal dysfunction in schizophrenia and unaffected relatives. Biological Psychiatry, 60, 32–39. doi: 10.1016/j.biopsych.2005.11.026Google Scholar
*Walcott, C.M., & Landau, S. (2004). The relation between disinhibition and emotion regulation in boys with attention deficit hyperactivity disorder. Journal of Clinical Child and Adolescent Psychology, 33, 772–782. doi: 10.1207/s15374424jccp3304_12CrossRefGoogle ScholarPubMed
*Willcutt, E.G., Pennington, B.F., Boada, R., Ogline, J.S., Tunick, R.A., Chhabildas, N.A., et al. . (2001). A comparison of the cognitive deficits in reading disability and attention-deficit/hyperactivity disorder. Journal of Abnormal Psychology, 110, 157–172. doi: 10.1037/0021-843X.110.1.157CrossRefGoogle ScholarPubMed
*Willcutt, E.G., Pennington, B.F., Olson, R.K., Chhabildas, N., & Hulslander, J. (2005). Neuropsychological analyses of comorbidity between reading disability and attention deficit hyperactivity disorder: In search of the common deficit. Developmental Neuropsychology, 27, 35–78. doi: 10.1207/s15326942dn2701_3Google Scholar
Williams, B.R., Ponesse, J.S., Schachar, R.J., Logan, G.D., & Tannock, R. (1999). Development of inhibitory control across the life span. Developmental Psychology, 35, 205–213. doi: 10.1037/0012-1649.35.1.205Google Scholar
*Wodushek, T.R., & Neumann, C.S. (2003). Inhibitory capacity in adults with symptoms of Attention Deficit/Hyperactivity Disorder (ADHD). Archives of Clinical Neuropsychology, 18, 317–330. doi: 10.1093/arclin/18.3.317Google Scholar
*Woolley, J., Heyman, I., Brammer, M., Frampton, I., McGuire, P.K., & Rubia, K. (2008). Brain activation in paediatric obsessive compulsive disorder during tasks of inhibitory control. British Journal of Psychiatry, 192, 25–31. doi: 10.1192/bjp.bp.107.036558Google Scholar
*Yang, T.T., Simmons, A.N., Matthews, S.C., Tapert, S.F., Frank, G.K., Bischoff-Grethe, A., et al. . (2009). Depressed adolescents demonstrate greater subgenual anterior cingulate activity. Neuroreport, 20, 440–444. doi: 10.1097/WNR.0b013e3283262e10Google Scholar
Yoo, S.Y., Roh, M.S., Choi, J.S., Kang, D.H., Ha, T.H., Lee, J.M., et al. . (2008). Voxel-based morphometry study of gray matter abnormalities in obsessive-compulsive disorder. Journal of Korean Medical Science, 23, 24–30. doi: 10.3346/jkms.2008.23.1.24CrossRefGoogle ScholarPubMed
Zakzanis, K.K. (2001). Statistics to tell the truth, the whole truth, and nothing but the truth: Formulae, illustrative numerical examples, and heuristic interpretation of effect size analyses for neuropsychological researchers. Archives of Clinical Neuropsychology, 16, 653–667. doi: 10.1093/arclin/16.7.653Google Scholar
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