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Frontal and Temporal Structural Connectivity Is Associated with Social Communication Impairment Following Traumatic Brain Injury

Published online by Cambridge University Press:  13 July 2016

Arianna Rigon ,
Michelle W. Voss ,
Lyn S. Turkstra ,
Bilge Mutlu  and
Melissa C. Duff
Arianna Rigon*
Affiliation:
Interdisciplinary Neuroscience Program, The University of Iowa, Iowa City, Iowa
Michelle W. Voss
Affiliation:
Interdisciplinary Neuroscience Program, The University of Iowa, Iowa City, Iowa Department of Psychological & Brain Sciences, The University of Iowa, Iowa City, Iowa
Lyn S. Turkstra
Affiliation:
Department of Communication Sciences and Disorders, The University of Wisconsin – Madison, Wisconsin Interdisciplinary Program in Neuroscience, The University of Wisconsin – Madison, Wisconsin
Bilge Mutlu
Affiliation:
Department of Computer Sciences, The University of Wisconsin – Madison, Wisconsin
Melissa C. Duff
Affiliation:
Interdisciplinary Neuroscience Program, The University of Iowa, Iowa City, Iowa Department of Communication Sciences and Disorders, The University of Iowa, Iowa City, Iowa Department of Neurology, The University of Iowa, Iowa City, Iowa
*
Correspondence and reprint requests to: Arianna Rigon, 420-I Seashore Hall, 328 Iowa Ave, Iowa City, IA 52242. E-mail: [email protected]
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Abstract

Objectives: Although it has been well documented that traumatic brain injury (TBI) can result in communication impairment, little work to date has examined the relationship between social communication skills and structural brain integrity in patients with TBI. The aim of the current study was to investigate the association between self- and other-perceived communication problems and white matter integrity in patients with mild to severe TBI. Methods: Forty-four individuals (TBI=24) and people with whom they frequently communicate, as well as demographically matched normal healthy comparisons (NC) and their frequent communication partners, were administered, respectively, the La-Trobe Communication Questionnaire Self form (LCQ-SELF) and Other form (LCQ-OTHER). In addition, diffusion tensor imaging data were collected, and fractional anisotropy (FA) measures were extracted for each lobe in both hemispheres. Results: Within the TBI group, but not within the NC group, participants who were perceived by their close others as having more communication problems had lower FA in the left frontal and temporal lobes (p<.01), but not in other brain regions. Conclusions: Frontotemporal white matter microstructural integrity is associated with social communication abilities in adults with TBI. This finding contributes to our understanding of the mechanisms leading to communication impairment following TBI and can inform the development of new neuromodulation therapies as well as diagnostic tools. (JINS, 2016, 22, 705–716)

Keywords

White matterCommunicationDiffusion tensor imagingFractional anisotropyFrontal lobeTemporal lobe
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 22 , Issue 7 , August 2016 , pp. 705 - 716
Copyright
Copyright © The International Neuropsychological Society 2016 

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