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Binge Drinking Relates to Worse Neurocognitive Functioning Among Adults Aging with HIV

Published online by Cambridge University Press:  26 July 2021

Emily W. Paolillo Open the ORCID record for Emily W. Paolillo [Opens in a new window] ,
Rowan Saloner ,
Maulika Kohli ,
C. Wei-Ming Watson ,
Raeanne C. Moore Open the ORCID record for Raeanne C. Moore [Opens in a new window] ,
Robert K. Heaton  and
David J. Moore Open the ORCID record for David J. Moore [Opens in a new window]
Emily W. Paolillo
Affiliation:
San Diego State University/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
Rowan Saloner
Affiliation:
San Diego State University/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
Maulika Kohli
Affiliation:
San Diego State University/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
C. Wei-Ming Watson
Affiliation:
San Diego State University/UC San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
Raeanne C. Moore
Affiliation:
UC San Diego, Department of Psychiatry, San Diego, CA, USA
Robert K. Heaton
Affiliation:
UC San Diego, Department of Psychiatry, San Diego, CA, USA
David J. Moore*
Affiliation:
UC San Diego, Department of Psychiatry, San Diego, CA, USA
*
*Correspondence and reprint requests to: David J. Moore, UC San Diego, HIV Neurobehavioral Research Program, 220 Dickinson St, Suite B, MC8231, San Diego, CA 92103-8231, USA. E-mail: [email protected]
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Abstract

Objective:

Given the aging population of people with HIV (PWH), along with increasing rates of binge drinking among both PWH and the general older adult population, this study examined the independent and interactive effects of HIV, binge drinking, and age on neurocognition.

Method:

Participants were 146 drinkers stratified by HIV and binge drinking status (i.e., ≥4 drinks for women and ≥5 drinks for men within approximately 2 h): HIV+/Binge+ (n = 30), HIV−/Binge+ (n = 23), HIV+/Binge− (n = 55), HIV−/Binge− (n = 38). All participants completed a comprehensive neuropsychological battery measuring demographically-corrected global and domain-specific neurocognitive T scores. ANCOVA models examined independent and interactive effects of HIV and binge drinking on neurocognitive outcomes, adjusting for overall alcohol consumption, lifetime substance use, sex, and age. Subsequent multiple linear regressions examined whether HIV/Binge group moderated the relationship between age and neurocognition.

Results:

HIV+/Binge+ participants had worse global neurocognition, processing speed, delayed recall, and working memory than HIV−/Binge− participants (p’s < .05). While there were significant main effects of HIV and binge drinking, their interaction did not predict any of those neurocognitive outcomes (p’s > .05). Significant interactions between age and HIV/Binge group showed that HIV+/Binge+ participants demonstrated steeper negative relationships between age and neurocognitive outcomes of learning, delayed recall, and motor skills compared to HIV−/Binge− participants (p’s < .05).

Conclusions:

Results showed adverse additive effects of HIV and binge drinking on neurocognitive functioning, with older adults demonstrating the most vulnerability to these effects. Findings support the need for interventions to reduce binge drinking, especially among older PWH.

Keywords

HIVAIDSalcohol-related disordersagedcognitive dysfunctionneurocognitive disorders
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 28 , Issue 6 , July 2022 , pp. 600 - 610
Copyright
Copyright © INS. Published by Cambridge University Press, 2021

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