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Systemically Treated Breast Cancer Patients and Controls: An Evaluation of the Presence of Noncredible Performance

Published online by Cambridge University Press:  10 March 2014

Jeffrey S. Wefel ,
Rozemarijn L. Kornet  and
Sanne B. Schagen
Jeffrey S. Wefel
Affiliation:
Department of Neuro-Oncology, M.D. Anderson Cancer Center, Houston, Texas
Rozemarijn L. Kornet
Affiliation:
Departement of Psychology, Vrije Universiteit, Amsterdam, The Netherlands
Sanne B. Schagen*
Affiliation:
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
*
Correspondence and reprint requests to: Sanne B. Schagen, Netherlands Cancer Institute, Division of Psychosocial Research and Epidemiology, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands. E-mail: [email protected]
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Abstract

This study sought to define the frequency of noncredible performance in breast cancer patients before, during and after completion of systemic treatment, as well as predictors of noncredible performance. We examined six datasets investigating the cognitive effects of chemotherapy and/or endocrine therapy. Embedded performance validity test (PVT) measures were identified and used to evaluate the datasets. One dataset included a standalone PVT. Possible noncredible performance was operationally defined as performance below criterion on three or more PVT indices. This was undertaken as cancer patients have been observed clinically to fail PVTs both in the context of external gain and independent of such motivators. A total of 534 breast cancer patients and 214 healthy controls were included in the analysis. Percentages of patients performing below cutoff on one or more PVT varied from 0% to 21.2%. Only 1 patient met the criterion of noncredible performance. Calculation of post-test probabilities indicated a more than 90% chance to detect noncredible performance. There is no evidence to suggest noncredible performance in breast cancer patients and healthy controls who choose to participate in research studies examining cognitive function. Thus, the observational data showing that non-central nervous system (CNS) cancer and therapies not targeting the CNS can have untoward effects on cognitive function are unlikely to be due to noncredible performance. (JINS, 2014, 19, 1–13)

Type
Symposia
Information
Journal of the International Neuropsychological Society , Volume 20 , Issue 4 , April 2014 , pp. 357 - 369
Copyright
Copyright © The International Neuropsychological Society 2014 

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