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Source memory and frontal functioning in Parkinson’s disease

Published online by Cambridge University Press:  01 May 2009

LAUREN L. DRAG ,
LINAS A. BIELIAUSKAS ,
ALFRED W. KASZNIAK ,
NICOLAAS I. BOHNEN  and
ELIZABETH L. GLISKY
LAUREN L. DRAG*
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, Michigan
LINAS A. BIELIAUSKAS
Affiliation:
Department of Neurology, University of Michigan, Ann Arbor, Michigan
ALFRED W. KASZNIAK
Affiliation:
Department of Psychology, University of Arizona, Tucson, Arizona
NICOLAAS I. BOHNEN
Affiliation:
Department of Neurology, University of Michigan, Ann Arbor, Michigan
ELIZABETH L. GLISKY
Affiliation:
Department of Psychology, University of Arizona, Tucson, Arizona
*
*Correspondence and reprint requests to: Lauren L. Drag, Division of Neuropsychology, Department of Psychiatry, University of Michigan, 2101 Commonwealth Boulevard, Suite C., Ann Arbor, Michigan 48105. E-mail: [email protected]
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Abstract

The most extensively described pathological abnormality in Parkinson’s disease (PD) is loss of dopaminergic neurons in the substantia nigra pars compacta and the ventral tegmental area, with degeneration of their striatal terminals. Because of the intimate connections between the striatum and the frontal lobes, individuals with PD often demonstrate impairments on those tasks relying on the prefrontal cortex (e.g., tests of executive functioning). Source memory, or memory for context, is believed to rely on the prefrontal cortex and has been previously associated with executive functioning performance, although it has received little attention in the PD literature. Executive functioning and source memory were measured in a group of nondemented PD patients and healthy control participants. Within the PD group, an anti-Parkinson’s medication withdrawal manipulation was used to examine whether source memory was affected by phasic changes in dopamine levels. Compared to healthy control participants, PD patients were impaired in source memory (both on- and off-medication) and on a composite measure of executive functioning. Within the PD group, medication administration improved motor performance but did not have a significant effect on source memory. (JINS, 2009, 15, 399–406.)

Keywords

DopamineCognitionFrontal lobeNeuropsychologyMedicationExecutive functioning
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 15 , Issue 3 , May 2009 , pp. 399 - 406
Copyright
Copyright © The International Neuropsychological Society 2009

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