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Motor and non-motor sequence learning in children and adolescents with cerebellar damage

Published online by Cambridge University Press:  01 July 2005

ANDREA BERGER ,
MICHELLE SADEH ,
GABRIEL TZUR ,
AVINOAM SHUPER ,
LIORA KORNREICH ,
DOV INBAR ,
IAN J. COHEN ,
SHALOM MICHOWIZ ,
ISAAC YANIV  and
SHLOMI CONSTANTINI
...Show all authors
ANDREA BERGER
Affiliation:
Ben-Gurion University of the Negev, Beer Sheva, Israel
MICHELLE SADEH
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Israel Cancer Association, Givataim, Israel
GABRIEL TZUR
Affiliation:
Ben-Gurion University of the Negev, Beer Sheva, Israel
AVINOAM SHUPER
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
LIORA KORNREICH
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
DOV INBAR
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
IAN J. COHEN
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
SHALOM MICHOWIZ
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
ISAAC YANIV
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
SHLOMI CONSTANTINI
Affiliation:
Dana Hospital, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
ELI VAKIL
Affiliation:
Bar-Ilan University, Ramat Gan, Israel
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Abstract

Cerebellar involvement in motor and non-motor sequence learning was examined with serial reaction time tasks (SRT). Our sample consisted of 8 children and adolescents who had undergone surgical removal of a benign posterior fossa tumor (PFT) during childhood. None of them had undergone chemotherapy or cranial radiation therapy (CRT). Ages ranged from 1–11 years at surgery and 9–17 years at testing. The children were tested not earlier than 2.5 years after surgery (M = 5.9 years), enabling brain plasticity and recovery of functions. Their performance was compared with a matched control sample. The PFT group was not impaired in the implicit learning of sequences, as reflected in their performance in blocks with a repeated sequence, both before and after a random block. However, in the perceptual task, their performance deteriorated more than that of the control group when a random block was introduced, suggesting that it was more difficult for the patients to respond flexibly or change their response set when encountering changing task demands. These results are in line with another study by our group on task switching with the same patients. (JINS, 2005, 11, 482–487.)

Keywords

Serial reaction timeProcedural learningMotor learningPerceptual learningCerebellumPosterior fossa tumor
Type
BRIEF COMMUNICATION
Information
Journal of the International Neuropsychological Society , Volume 11 , Issue 4 , July 2005 , pp. 482 - 487
Copyright
© 2005 The International Neuropsychological Society

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