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Motor and non-motor sequence learning in children and adolescents with cerebellar damage

Published online by Cambridge University Press:  01 July 2005

ANDREA BERGER ,
MICHELLE SADEH ,
GABRIEL TZUR ,
AVINOAM SHUPER ,
LIORA KORNREICH ,
DOV INBAR ,
IAN J. COHEN ,
SHALOM MICHOWIZ ,
ISAAC YANIV  and
SHLOMI CONSTANTINI
...Show all authors
ANDREA BERGER
Affiliation:
Ben-Gurion University of the Negev, Beer Sheva, Israel
MICHELLE SADEH
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Israel Cancer Association, Givataim, Israel
GABRIEL TZUR
Affiliation:
Ben-Gurion University of the Negev, Beer Sheva, Israel
AVINOAM SHUPER
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
LIORA KORNREICH
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
DOV INBAR
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
IAN J. COHEN
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
SHALOM MICHOWIZ
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
ISAAC YANIV
Affiliation:
Schneider Children's Medical Center, Petach Tikva, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
SHLOMI CONSTANTINI
Affiliation:
Dana Hospital, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
ELI VAKIL
Affiliation:
Bar-Ilan University, Ramat Gan, Israel
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Abstract

Cerebellar involvement in motor and non-motor sequence learning was examined with serial reaction time tasks (SRT). Our sample consisted of 8 children and adolescents who had undergone surgical removal of a benign posterior fossa tumor (PFT) during childhood. None of them had undergone chemotherapy or cranial radiation therapy (CRT). Ages ranged from 1–11 years at surgery and 9–17 years at testing. The children were tested not earlier than 2.5 years after surgery (M = 5.9 years), enabling brain plasticity and recovery of functions. Their performance was compared with a matched control sample. The PFT group was not impaired in the implicit learning of sequences, as reflected in their performance in blocks with a repeated sequence, both before and after a random block. However, in the perceptual task, their performance deteriorated more than that of the control group when a random block was introduced, suggesting that it was more difficult for the patients to respond flexibly or change their response set when encountering changing task demands. These results are in line with another study by our group on task switching with the same patients. (JINS, 2005, 11, 482–487.)

Keywords

Serial reaction timeProcedural learningMotor learningPerceptual learningCerebellumPosterior fossa tumor
Type
BRIEF COMMUNICATION
Information
Journal of the International Neuropsychological Society , Volume 11 , Issue 4 , July 2005 , pp. 482 - 487
Copyright
© 2005 The International Neuropsychological Society

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References

REFERENCES

Aarsen, F.K., Van Dongen, H.R., Paquier, P.F., Van Mourik, M., & Catsman-Berrevoets, C.E. (2004). Long-term sequelae in children after cerebellar astrocytoma surgery. Neurology, 62, 1311–1316.Google Scholar
Berger, A., Sadeh, M., Tzur, G., Shuper, A., Kornreich, L., Inbar, D., Cohen, I.J., Michowiz, Sh., Yaniv, I., Constantini, Sh., Kessler, Y., & Meiran, N. (2005). Task switching after cerebellar damage. Neuropsychology. In press.Google Scholar
Colvin, A.N., Yeates, K.O., Enrile, B.G., & Coury, D.L. (2003). Motor adaptation in children with myelomeningocele: Comparison to children with ADHD and healthy siblings. Journal of the International Neuropsychological Society, 9, 642–652.Google Scholar
Doyon, J. (1997). Skill learning. In R. Bradley, R. Harris & P. Jenner (Series Eds.) & J.D. Schamahmann (Vol. Ed.), International review of neurobiology: Vol. 41, The cerebellum and cognition (pp. 273–294). San Diego, CA: Academic Press.
Doyon, J., Owen, A.M., Petrides, M., Szkilas, V., & Evans, A.C. (1996). Functional anatomy of visuomotor skill learning in human participants examined with positron emission tomography. European Journal of Neuroscience, 8, 637–48.Google Scholar
Friston, K.J., Frith, C.D., Passingham, R.E., Liddle, P.F., & Frackowiak, R.S.J. (1992). Motor practice and neuropsychological adaptation in the cerebellum: A positron tomography study. Proceedings of the Royal Society of London. Series B Biological Sciences, 248, 223–228.Google Scholar
Grafton, S.T., Hazeltine, E., & Ivry, R.E. (1995). Functional mapping of sequence learning in normal humans. Journal of Cognitive Neuroscience, 7, 497–510.Google Scholar
Grill, J., Renaux, V.K., Bulteau, C., Viguier, D., Levy-Piebois, C., Sainte-Rose, C., Dellatolas, G., Raquin, M.A., Jambaque, I., & Kalifa, C. (1999). Long-term intellectual outcome in children with posterior fossa tumors according to radiation doses and volumes. International Journal of Radiation, Oncology, Biology, Physics, 45, 137–145.Google Scholar
Hallet, M. & Grafman, J. (1997). Executive function and motor skill learning. In R. Bradley, R. Harris, & P. Jenner (Series Eds.) & J.D. Schamahmann (Vol. Ed.), International Review of Neurobiology: Vol. 41, The cerebellum and cognition (pp. 297–323). San Diego, CA: Academic Press.
Hetherington, R., Dennis, M., & Spiegler, B. (2000). Perception and estimation of time in long-term survivors of childhood posterior fossa tumors. Journal of the International Neuropsychological Society, 6, 682–692.Google Scholar
Laforce, R. & Doyon, J. (2001). Distinct contribution of the striatum and cerebellum to motor learning. Brain and Cognition, 45, 189–211.Google Scholar
Levisohn, L., Cronin-Golomb, A., & Schamahmann, J.D. (2000). Neuropsychological consequences of cerebellar tumor resection in children: Cerebellar cognitive affective syndrome in a paediatric population. Brain, 123, 1041–1050.Google Scholar
Nissen, M.J. & Bullemer, P. (1987). Attentional requirements of learning: Evidence from performance measures. Cognitive Psychology, 19, 1–32.Google Scholar
Pascual-Leone, A., Grafman, J., Clark, K., Stewart, M., Massaqoui, S., Lou, J.S., & Hallett, M. (1993). Procedural learning in Parkinson's disease and cerebellar degeneration. Annals of Neurology, 34, 594–602.Google Scholar
Pollack, I.F. (1997). Posterior fossa syndrome. In R. Bradley, R. Harris, & P. Jenner (Series Eds.) & J.D. Schamahmann (Vol. Ed.), International Review of Neurobiology: Vol 41, The cerebellum and cognition (pp. 411–432). San Diego, CA: Academic Press.
Sadeh, M., Berger, A., Tzur, G., Shuper, A., Kornreich, L., Constantini, S., Friedman, O., Michowiz, S., Cohen, I.J., Yaniv, I., & Inbar, D. (2005). Overcoming early cerebellar injury: Neuropsychological long-term sequela of posterior fossa tumors in childhood. Manuscript submitted for publication.
Seidler, R.D., Purushotham, A., Kim, S.G., Ugurbil, K., Willigham, D., & Ashe, J. (2002). Cerebellum activation associated with performance change but not motor learning. Science, 296, 2043–2046.Google Scholar
Seitz, R.J., Roland, E., Bohm, C., Greitz, T., & Stone-Elander, S. (1990). Motor learning in man: A positron emission tomographic study. NeuroReport, 1, 57–60.Google Scholar
Squire, L.R. (1992). Declarative and nondeclarative memory: Multiple brain systems supporting learning and memory. Journal of Cognitive Neuroscience, 4, 232–243.CrossRefGoogle Scholar
Steinlin, M., Imfeld, S., Zulauf, P., Boltshauser, E., Lovblad, K.-O., Luthy, A.R., Perrig, W., & Kaufmann, F. (2003). Neuropsychological long-term sequelae after posterior fossa tumor resection during childhood. Brain, 126, 1998–2008.Google Scholar
Vakil, E., Kahan, S., Huberman, M., & Osimani. A. (2000). Motor and non-motor sequence learning in patients with basal ganglia lesions: The case of serial reaction time (SRT). Neuropsychologia, 38, 1–10.Google Scholar
Vakil, E., Kraus, A., Bor, B., & Groswasser, Z. (2002). Impaired skill learning in patients with severe close-head injury as demonstrated by the serial reaction time (SRT) task. Brain and Cognition, 50, 304–315.Google Scholar
Wechsler, D. (1974). Manual for the Wechsler Intelligence Scale for Children–Revised. New York: The Psychological Corporation.