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Heavy Alcohol Use, Marijuana Use, and Concomitant Use by Adolescents Are Associated with Unique and Shared Cognitive Decrements

Published online by Cambridge University Press:  22 September 2014

Jennifer L. Winward ,
Karen L. Hanson ,
Susan F. Tapert  and
Sandra A. Brown
Jennifer L. Winward
Affiliation:
Department of Psychology, University of California, San Diego, La Jolla, California
Karen L. Hanson
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California VA Center of Excellence for Stress and Mental Health, San Diego, California Veterans Affairs San Diego Healthcare System, San Diego, California
Susan F. Tapert
Affiliation:
Department of Psychiatry, University of California, San Diego, La Jolla, California Veterans Affairs San Diego Healthcare System, San Diego, California
Sandra A. Brown*
Affiliation:
Department of Psychology, University of California, San Diego, La Jolla, California Department of Psychiatry, University of California, San Diego, La Jolla, California
*
Correspondence and reprint requests to: Sandra A. Brown, University of California, San Diego, 9500 Gilman Drive (MC 0043), La Jolla, CA 92093-0043. E-mail: [email protected]
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Abstract

To assess recovery of cognitive effects, we investigated neuropsychological performance after 1 month of monitored abstinence in teens with histories of heavy episodic drinking, protracted marijuana use, or concomitant use of alcohol and marijuana. Adolescents (ages 16–18 years) with histories of heavy episodic drinking (HED; n=24), marijuana use (MJ; n=20), both heavy alcohol and marijuana use (HED+MJ; n=29), and socio-demographically similar control teens (CON; n=55) completed a neuropsychological battery following 4 weeks of monitored abstinence. Groups were similar on 5th grade standardized test scores, suggesting comparable academic functioning before onset of substance use. Relative to CON, HED showed poorer cognitive flexibility (p=.006), verbal recall (p=.024), semantic clustering (p=.011), and reading skills (p=.018). MJ performed worse than CON on inhibition task accuracy (p=.015), cued verbal memory (p=.031), and psychomotor speed (p=.027). Similar to HED youth, HED+MJ showed differences relative to CON on cognitive flexibility (p=.024) and verbal recall (p=.049). As with MJ teens, HED+MJ showed poorer task accuracy (p=.020). Unique to the HED+MJ group was poorer working memory (p=.012) relative to CON. For all substance using participants, worse performance across domains correlated with more lifetime use of alcohol and of marijuana, more withdrawal symptoms from alcohol, and earlier age of onset of marijuana use (ps<.05). Heavy alcohol use, marijuana use, and concomitant use of both substances during adolescence appear to be associated with decrements in cognitive functioning, and each substance (or combination of substances) may be linked to poorer performance in specific cognitive domains (JINS, 2014, 20, 784–795).

Keywords

Neuropsychological performanceAlcoholMarijuanaExecutive functioningMemoryLanguage
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 20 , Issue 8 , September 2014 , pp. 784 - 795
Copyright
Copyright © The International Neuropsychological Society 2014 

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