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Does Apolipoprotein e4 Status Moderate the Association of Family Environment with Long-Term Child Functioning following Early Moderate to Severe Traumatic Brain Injury? A Preliminary Study

Published online by Cambridge University Press:  02 August 2016

Amery Treble-Barna ,
Huaiyu Zang ,
Nanhua Zhang ,
Lisa J. Martin ,
Keith Owen Yeates ,
H. Gerry Taylor ,
Shari L. Wade  and
Brad G. Kurowski
Amery Treble-Barna*
Affiliation:
Division of Physical Medicine and Rehabilitation, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio
Huaiyu Zang
Affiliation:
Division of Biostatistics and Epidemiology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio
Nanhua Zhang
Affiliation:
Division of Biostatistics and Epidemiology, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio
Lisa J. Martin
Affiliation:
Division of Human Genetics, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio
Keith Owen Yeates
Affiliation:
Deparment of Psychology, Alberta Children’s Hospital Research Institute, & Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
H. Gerry Taylor
Affiliation:
Division of Developmental and Behavioral Pediatrics and Psychology, Department of Pediatrics, Case Western Reserve University and Rainbow Babies and Children’s Hospital, University Hospitals Case Medical Center, Cleveland, Ohio
Shari L. Wade
Affiliation:
Division of Physical Medicine and Rehabilitation, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio
Brad G. Kurowski
Affiliation:
Division of Physical Medicine and Rehabilitation, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center and University of Cincinnati College of Medicine, Cincinnati, Ohio
*
Correspondence and reprint requests to: Amery Treble-Barna, Division of Pediatric Physical Medicine and Rehabilitation, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039. E-mail: [email protected]
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Abstract

Objectives: To examine whether apolipoprotein e4 (APOE) status moderates the association of family environment with child functioning following early traumatic brain injury (TBI). Methods: Sixty-five children with moderate to severe TBI and 70 children with orthopedic injury (OI) completed assessments 6, 12, 18 months, and 3.5 and 6.8 years post injury. DNA was extracted from saliva samples and genotyped for APOE e4 status. Linear mixed models examined moderating effects of APOE e4 status on associations between two family environment factors (parenting style, home environment) and three child outcomes (executive functioning, behavioral adjustment, adaptive functioning). Results: Children with TBI who were carriers of the e4 allele showed poorer adaptive functioning relative to non-carriers with TBI and children with OI in the context of low authoritarianism. At high levels of authoritarianism, non-carriers with TBI showed the poorest adaptive functioning among groups. There were no main effects or interactions involving APOE and executive functioning or behavioral adjustment. Conclusions:The APOE e4 allele was detrimental for long-term adaptive functioning in the context of positive parenting, whereas in less optimal parenting contexts, being a non-carrier was detrimental. We provide preliminary evidence for an interaction of APOE e4 status and parenting style in predicting long-term outcomes following early TBI. (JINS, 2016, 22, 859–864)

Keywords

Adaptive functionBrain injuriesGeneticsGene–environment interactionParenting styleNeurobehavioral outcomes
Type
Brief Communications
Information
Journal of the International Neuropsychological Society , Volume 22 , Issue 8 , September 2016 , pp. 859 - 864
Copyright
Copyright © The International Neuropsychological Society 2016 

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References

Achenbach, T.M., & Rescorla, L.A. (2001). Manual for ASEBA School-Age Forms & Profiles. Burlington, VT: University of Vermont, Research Center for Children, Youth, & Families.Google Scholar
Baumrind, D. (1966). Effects of authoritative parental control on child behavior. Child Development, 887–907.Google Scholar
Berg, K., Kondo, I., Drayna, D., & Lawn, R. (1989). “Variability gene” effect of cholesteryl ester transfer protein (CETP) genes. Clinical Genetics, 35(6), 437–445.CrossRefGoogle ScholarPubMed
Bradley, R.H., & Caldwell, B.M. (1984). The HOME Inventory and family demographics. Developmental Psychology, 20(2), 315.CrossRefGoogle Scholar
Brichtova, E., & Kozak, L. (2008). Apolipoprotein E genotype and traumatic brain injury in children--Association with neurological outcome. Child’s Nervous System, 24(3), 349–356. doi:10.1007/s00381-007-0459-6 Google Scholar
Crawford, F.C., Vanderploeg, R.D., Freeman, M.J., Singh, S., Waisman, M., Michaels, L., & Mullan, M.J. (2002). APOE genotype influences acquisition and recall following traumatic brain injury. Neurology, 58(7), 1115–1118.Google Scholar
Friedman, G., Froom, P., Sazbon, L., Grinblatt, I., Shochina, M., Tsenter, J., & Groswasser, Z. (1999). Apolipoprotein E-ε4 genotype predicts a poor outcome in survivors of traumatic brain injury. Neurology, 52(2), 244–248.Google Scholar
Gioia, G.A., Isquith, P.K., Guy, S.C., & Kenworthy, L. (2000). Behavior rating inventory of executive function. Odessa, FL: Psychological Assessment Resources.Google Scholar
Hodges, K., Wong, M.M., & Latessa, M. (1998). Use of the Child and Adolescent Functional Assessment Scale (CAFAS) as an outcome measure in clinical settings. The Journal of Behavioral Health Services & Research, 25(3), 325–336.CrossRefGoogle ScholarPubMed
Holm, S. (1979). A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics, 6, 65–70.Google Scholar
Ihle, A., Bunce, D., & Kliegel, M. (2012). APOE ε4 and cognitive function in early life: A meta-analysis. Neuropsychology, 26(3), 267–277.Google Scholar
Kassam, I., Gagnon, F., & Cusimano, M.D. (2016). Association of the APOE-ε4 allele with outcome of traumatic brain injury in children and youth: A meta-analysis and meta-regression. Journal of Neurology, Neurosurgery, & Psychiatry, 87, 433–440.Google Scholar
Kurowski, B., Backeljauw, B., Zang, H., Zhang, N., Martin, L.J., Pilipenko, V., & Wade, S. (2015). Influence of catechol-O-methyltransferase on executive functioning longitudinally after early childhood traumatic brain injury: Preliminary findings. The Journal of Head Trauma Rehabilitation, 31(3), E1–E9.Google Scholar
Kurowski, B., Martin, L.J., & Wade, S.L. (2012). Genetics and outcomes after traumatic brain injury (TBI): What do we know about pediatric TBI? Journal of Pediatric Rehabilitation Medicine, 5(3), 217–231. doi:10.3233/PRM-2012-0214 CrossRefGoogle ScholarPubMed
Lee, B.K., Glass, T.A., James, B.D., Bandeen-Roche, K., & Schwartz, B.S. (2011). Neighborhood psychosocial environment, apolipoprotein E genotype, and cognitive function in older adults. Archives of General Psychiatry, 68(3), 314–321.CrossRefGoogle ScholarPubMed
Liberman, J.N., Stewart, W.F., Wesnes, K., & Troncoso, J. (2002). Apolipoprotein E ε4 and short-term recovery from predominantly mild brain injury. Neurology, 58(7), 1038–1044.Google Scholar
Lichtman, S.W., Seliger, G., Tycko, B., & Marder, K. (2000). Apolipoprotein E and functional recovery from brain injury following postacute rehabilitation. Neurology, 55(10), 1536–1539.Google Scholar
Lo, T.Y., Jones, P.A., Chambers, I.R., Beattie, T.F., Forsyth, R., Mendelow, A.D., && Minns, R.A. (2009). Modulating effect of apolipoprotein E polymorphisms on secondary brain insult and outcome after childhood brain trauma. Child’s Nervous System, 25(1), 47–54. doi:10.1007/s00381-008-0723-4 Google Scholar
McClelland, G.H., Judd, C.M. (1993). Statistical difficulties of detecting interactions and moderator effects. Psychological Bulletin, 114, 376–390.Google Scholar
Ost, M., Nylen, K., Csajbok, L., Blennow, K., Rosengren, L., & Nellgard, B. (2008). Apolipoprotein E polymorphism and gender difference in outcome after severe traumatic brain injury. Acta Anaesthesiologica Scandinavica, 52(10), 1364–1369. doi:10.1111/j.1399-6576.2008.01675.x Google Scholar
Ponsford, J., McLaren, A., Schönberger, M., Burke, R., Rudzki, D., Olver, J., &&Ponsford, M. (2011). The association between apolipoprotein E and traumatic brain injury severity and functional outcome in a rehabilitation sample. Journal of Neurotrauma, 28(9), 1683–1692.Google Scholar
Quinn, T.J., Smith, C., Murray, L., Stewart, J., Nicoll, J.A., & Graham, D.I. (2004). There is no evidence of an association in children and teenagers between the apolipoprotein E epsilon4 allele and post-traumatic brain swelling. Neuropathology and Applied Neurobiology, 30(6), 569–575. doi:10.1111/j.1365-2990.2004.00581.x Google Scholar
Ritchie, K., Jaussent, I., Stewart, R., Dupuy, A.M., Courtet, P., Malafosse, A., &&Ancelin, M.L. (2011). Adverse childhood environment and late‐life cognitive functioning. International Journal of Geriatric Psychiatry, 26(5), 503–510.Google Scholar
Robinson, C.C., Mandleco, B., Olsen, S.F., & Hart, C.H. (1995). Authoritative, authoritarian, and permissive parenting practices: Development of a new measure. Psychological Reports, 77(3), 819–830.Google Scholar
Teasdale, G., & Jennett, B. (1974). Assessment of coma and impaired consciousness. A practical scale. Lancet, 2(7872), 81–84.Google Scholar
Teasdale, G.M., Murray, G.D., & Nicoll, J.A. (2005). The association between APOE epsilon4, age and outcome after head injury: A prospective cohort study. Brain, 128(Pt 11), 2556–2561. doi:10.1093/brain/awh595 Google Scholar
Yeates, K.O., Taylor, H.G., Walz, N.C., Stancin, T., & Wade, S.L. (2010). The family environment as a moderator of psychosocial outcomes following traumatic brain injury in young children. Neuropsychology, 24(3), 345–356. doi:10.1037/a0018387 Google Scholar