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Delayed recognition memory span in HIV-1 infection

Published online by Cambridge University Press:  26 February 2009

Eileen M. Martin ,
David L. Pitrak ,
Kenneth J. Pursell ,
Kathleen M. Mullane  and
Richard M. Novak
Eileen M. Martin
Affiliation:
Departments of Psychiatry and Neurology, University of Illinois-Chicago, Chicago, Illinois 60612 Veterans Affairs Medical Center-West Side, Chicago, Illinois 60612
David L. Pitrak
Affiliation:
Department of Medicine-Section of Infectious Disease, University of Illinois-Chicago, Chicago, Illinois 60612 Veterans Affairs Medical Center-West Side, Chicago, Illinois 60612
Kenneth J. Pursell
Affiliation:
Department of Medicine-Section of Infectious Disease, University of Illinois-Chicago, Chicago, Illinois 60612 Veterans Affairs Medical Center-West Side, Chicago, Illinois 60612
Kathleen M. Mullane
Affiliation:
Department of Medicine-Section of Infectious Disease, University of Illinois-Chicago, Chicago, Illinois 60612 Veterans Affairs Medical Center-West Side, Chicago, Illinois 60612
Richard M. Novak
Affiliation:
Department of Medicine-Section of Infectious Disease, University of Illinois-Chicago, Chicago, Illinois 60612 Veterans Affairs Medical Center-West Side, Chicago, Illinois 60612
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Abstract

We administered a spatial version of the Delayed Recognition Span Test (DRST), a working memory task performed abnormally by patients with basal ganglia disease, to a group of 96 HIV-seropositive and 83 seronegative subjects with a high prevalence of substance abuse. For comparison purposes, we also administered the Symbol-Digit Modalities Test (SDMT) and the Trail Making Test (TMT), measures which detect HIV-related mental slowing efficiently in gay men but are nonspecifically impaired in subjects with a history of substance abuse. As predicted, scores on the TMT and the SDMT did not discriminate the groups, but HIV-seropositive subjects had significantly shorter spatial spans (p < .007) and DRST total scores (p < .005). These effects could not be attributed to differences in age, education, estimated intelligence, or psychological distress, because the groups were well matched on these variables. The DRST is a promising measure of HIV-related cognitive dysfunction in substance abusers, who are often nonspecifically impaired on psychomotor tasks. These preliminary data also indicate that working memory function should be studied further in HIV-seropositive subjects. (JINS, 1995, 1, 575–580.)

Keywords

HIV-1DementiaWorking memoryDrug abuse
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 1 , Issue 6 , November 1995 , pp. 575 - 580
Copyright
Copyright © The International Neuropsychological Society 1995

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