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Asymmetry of the hippocampus and amygdala in MRI volumetric measurements of normal adults

Published online by Cambridge University Press:  01 September 2004

OTTO PEDRAZA ,
DAWN BOWERS  and
ROBIN GILMORE
OTTO PEDRAZA
Affiliation:
Department of Clinical and Health Psychology, University of Florida, Box 100165, Gainesville, Florida 32610 Cognitive Neuroscience Laboratory, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610
DAWN BOWERS
Affiliation:
Department of Clinical and Health Psychology, University of Florida, Box 100165, Gainesville, Florida 32610 Cognitive Neuroscience Laboratory, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610
ROBIN GILMORE
Affiliation:
Department of Neurology, University of Florida College of Medicine, Gainesville, Florida 32610
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Abstract

Multiple studies have explored the relationship between MRI-based volumetric measurements of the hippocampus and amygdala, the degree of volumetric asymmetry of these structures, and symptom manifestation. However, considerable variability exists with regard to the reported volumetric values of these structures. The present study employed meta-analytic procedures to provide a systematic analysis of the normal population parameters of hippocampal and amygdala volumetric asymmetry as well as the absolute intrahemispheric volumes of these structures in normal adults. A literature review of studies published between 1990 and 2002 resulted in a representative sample of 82 studies (N = 3,564 participants) providing volumetric information of the hippocampus and 51 studies (N = 2,000 participants) providing volumetric information of the amygdala. Results revealed that both the hippocampus and the amygdala are reliably asymmetrical structures in normal adults, with larger right hippocampal (D = 0.21, p < .001) and right amygdala (D = 0.09, p < .01) volumes. Additional analyses indicated that differences in MRI magnet field strength and slice thickness values might differentially contribute to volumetric asymmetry estimates. These results expand on previous volumetric normative studies and may be relevant to investigators studying the clinical correlates of hippocampal and amygdala volumes. (JINS, 2004, 10, 664–678.)

Keywords

HippocampusAmygdalaMeta-analysisAsymmetryVolumeMRI
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 5 , September 2004 , pp. 664 - 678
Copyright
2004 The International Neuropsychological Society

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