Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-12-02T22:03:21.095Z Has data issue: false hasContentIssue false

3 Development of a Computerized Neurocognitive Battery for Children and Adolescents Affected by Human Immunodeficiency Virus in Botswana

Published online by Cambridge University Press:  21 December 2023

J. Cobb Scott*
Affiliation:
University of Pennsylvania, Philadelphia, PA, USA. Crescent VA Medical Center, Philadelphia, PA, USA.
Tyler M Moore
Affiliation:
University of Pennsylvania, Philadelphia, PA, USA.
Amelia E Van Pelt
Affiliation:
University of Pennsylvania, Philadelphia, PA, USA.
Mogomotsi Matshaba
Affiliation:
Baylor-Botswana Children’s Centre of Excellence, Gaborone, Botswana.
Ontibile Tshume
Affiliation:
Baylor-Botswana Children’s Centre of Excellence, Gaborone, Botswana.
Onkemetse Phoi
Affiliation:
Baylor-Botswana Children’s Centre of Excellence, Gaborone, Botswana.
Boitumelo Thuto
Affiliation:
Baylor-Botswana Children’s Centre of Excellence, Gaborone, Botswana.
Ruben C Gur
Affiliation:
University of Pennsylvania, Philadelphia, PA, USA.
Elizabeth D Lowenthal
Affiliation:
University of Pennsylvania, Philadelphia, PA, USA. Children’s Hospital of Philadelphia, Philadelphia, PA, USA
*
Correspondence: J. Cobb Scott, University of Pennsylvania and Crescenz VA Medical Center, [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Objective:

Children born to mothers infected with human immunodeficiency virus (HIV) during pregnancy experience increased risk of neurocognitive impairment. In Botswana, HIV infection is common, but standardized cognitive testing is limited. The Penn Computerized Neurocognitive Battery (PennCNB) is a widely used cognitive test battery that streamlines evaluation of neurocognitive functioning. Our group translated and culturally adapted the PennCNB for use among children and adolescents in this high-burden, low-resource setting. The current study examined the construct validity and sensitivity to HIV infection and exposure of the culturally adapted PennCNB among a cohort of HIV-affected children and adolescents in Gaborone, Botswana.

Participants and Methods:

628 school-aged children aged 7-17 years (n=223 children living with HIV [HIV+]; n=204 HIV exposed, uninfected [HEU]; and 201 HIV unexposed, uninfected [HUU]) completed the PennCNB. Participants were recruited from a clinic specializing in the care and treatment of HIV+ children and adolescents in Gaborone, Botswana, as well as from local schools. Confirmatory factor analyses were performed on efficiency measures for 13 PennCNB tests. Multiple regressions examined associations between HIV and neurocognitive functioning while controlling for age and sex. Multivariate normative comparisons were used to examine rates of overall cognitive impairment by comparing individual profiles of test scores to the multivariate distribution of test scores using age-normed data from the HUU group.

Results:

Confirmatory factor analysis supported four hypothesized neurocognitive domains: executive functioning, episodic memory, complex cognition, and sensorimotor/processing speed. As expected, there were main effects of age on cognitive performance across all domains (ps < .001), and there were small sex differences, with females performing better in executive functioning and males performing better on visuospatial processing. Children and adolescents living with HIV performed significantly worse than HUU across all domains (ps < .001), with the largest effect sizes on measures of abstraction, working memory, and processing speed. HEU also performed worse than HUU across several domains, with smaller effect sizes. Multivariate normative comparisons indicated that 27% of the HIV+ group evidenced global neurocognitive impairment.

Conclusions:

Overall, results support the validity of a neurocognitive battery adapted for use in Botswana, a non-Western, resource-limited setting. Results indicated that the adapted battery applied to children and adolescents with limited computer familiarity had a similar factor structure as in Western settings, indicating that the PennCNB appeared to assess the hypothesized neurocognitive domains. Hypothesized associations with age and sex supported the battery’s construct validity. Moreover, the battery appears to be sensitive to cognitive impairments associated with perinatally-acquired HIV and in utero HIV-related exposures, as it discriminated between the HUU, HIV+, and HEU groups. Differences were found in specific domains and in detection of overall impairment, including approximately one quarter of children and adolescents living with HIV in this cohort evidencing global neurocognitive impairment. Together, these results provide evidence that the PennCNB could serve as a useful tool for the assessment of neurocognitive functioning in school-aged children and adolescents from Botswana and, potentially, other resource-limited settings.

Type
Poster Session 02: Acute & Acquired Brain Injury
Copyright
Copyright © INS. Published by Cambridge University Press, 2023