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A Pilot Study to Investigate the Efficacy of Nicotine Oral Soluble Film, Lozenge and Gum in Relief of Acute Smoking Cue-provoked Craving for Cigarette in Low Dependence Smokers

Published online by Cambridge University Press:  26 February 2014

Daniel Du ,
James Borders ,
Alex Selmani  and
William Waverczak
Daniel Du*
Affiliation:
GSK Consumer Healthcare, New Jersey
James Borders
Affiliation:
Central Kentucky Research Associates, Inc., Kentucky
Alex Selmani
Affiliation:
GSK Consumer Healthcare, New Jersey
William Waverczak
Affiliation:
GSK Consumer Healthcare, New Jersey
*
Address for correspondence: Daniel Du, GSK Consumer Healthcare, 1500 Littleton Road, Parsippany, New Jersey 07054 E-mail: [email protected]
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Abstract

Introduction: A new nicotine film that releases nicotine quickly may lead to faster craving relief.

Aims: This study compares the efficacy of 2.5 mg nicotine film with 2 mg nicotine lozenge and 2 mg nicotine gum on relieving provoked craving in low dependence smokers.

Methods: A randomised, open-label, active comparators controlled study was conducted in 120 subjects. Subjects were abstinent from smoking for 4 hours prior to being provoked with smoking cues. After post-provocation craving assessment, subjects were administered one dose of the 3 treatments: nicotine film, lozenge, or gum. Craving intensity was then assessed at 50 seconds, 3, 5, 7, 15, 20, 25 and 30 minutes after administration.

Results/Findings: Three treatments reduced craving with similar maximum effects. The effect was maintained up to 30 minutes. Nicotine film significantly reduced more craving than lozenge at 50 seconds, 3 and 5 minutes. It also significantly reduced more craving than gum at 50 seconds and 3 minutes. There was no significant difference between lozenge and gum.

Conclusions: Nicotine film, lozenge and gum have similar maximum craving relief. Nicotine film significantly reduced more craving than lozenge and gum at early time points. Nicotine film may be particularly useful to provide acute craving relief.

Keywords

smokingcravingsmoking cessationnicotine oral soluble filmnicotine lozengenicotine gumnicotine replacement therapylow dependence smokerprovocationnicotine strips
Type
Articles
Information
Journal of Smoking Cessation , Volume 10 , Issue 2 , December 2015 , pp. 87 - 95
Copyright
Copyright © The Author(s), published by Cambridge University Press on behalf of Australian Academic Press Pty Ltd 2014 

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