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The value of quantitative pentavalent 99mTc-dimercaptosuccinic acid scan in predicting progression-free survival and overall survival in patients with glioblastoma multiforme

Published online by Cambridge University Press:  14 April 2020

Ehab Saad Open the ORCID record for Ehab Saad [Opens in a new window] ,
Ahmed Badawy ,
Mahasen Abougabal  and
Ahmed Kandeel
Ehab Saad*
Affiliation:
Department of Clinical Oncology, Cairo University, Kasr Alaini, Cairo, Egypt
Ahmed Badawy
Affiliation:
Department of Clinical Oncology, Cairo University, Kasr Alaini, Cairo, Egypt
Mahasen Abougabal
Affiliation:
Department of Clinical Oncology, Cairo University, Kasr Alaini, Cairo, Egypt
Ahmed Kandeel
Affiliation:
Department of Clinical Oncology, Cairo University, Kasr Alaini, Cairo, Egypt
*
Author for correspondence: Ehab Saad, Department of Clinical Oncology, Cairo University, Kasr Alaini, Cairo, Egypt. E-mail: [email protected]
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Abstract

Aim:

Glioblastoma multiforme (GBM) is the commonest and the most aggressive primary brain tumour. Pentavalent 99mTc-dimercaptosuccinic acid (99mTc (V)-DMSA) has been found to be a tumour-seeking agent. Pre-radiotherapy 99mTc (V)-DMSA positive scan was found to be significantly correlated with poor progression-free survival (PFS) and overall survival (OS). This study aims at evaluating the impact of quantitative 99mTc (V)-DMSA tumour uptake before and after radiotherapy on PFS and OS in patients with GBM.

Methods:

A prospective study included 40 patients with GBM. Single-photon emission computed tomography studies were done before and after adjuvant radiotherapy and were qualitatively and quantitatively evaluated. The retention index (RI) of the viable tumour was correlated with PFS and OS.

Results:

The qualitative enhancement of 99mTc (V)-DMSA uptake either positive or negative was significantly correlated with PFS at both early and late images (p-values 0·04 and 0·026, respectively) and OS only in the late image (p-value 0·036). The calculated ion/non-lesion ratios at late images were statistically correlated with PFS and OS (p-values 0·021 and 0·025, respectively). The baseline RI had significant correlation with PFS only (p-value 0·01).

Conclusion:

The degree of 99mTc (V)-DMSA scan positivity is a poor prognostic factor for PFS and OS in GBM patients.

Keywords

brain SPECTGlioblastoma multiforme (GBM)Prediction of PFS and OS in GBMQuantitative 99mTc (V)-DMSA scanValue of DMSA scan
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 20 , Issue 2 , June 2021 , pp. 203 - 209
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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