Hostname: page-component-cd9895bd7-gxg78 Total loading time: 0 Render date: 2024-12-26T21:03:10.621Z Has data issue: false hasContentIssue false
  • English
  • Français

The role of radiotherapy for large and locally advanced non-melanoma skin carcinoma

Published online by Cambridge University Press:  13 February 2012

Chance Matthiesen ,
Christina Forest ,
J. Spencer Thompson ,
Salahuddin Ahmad ,
Terence Herman  and
Carl Bogardus
Chance Matthiesen*
Affiliation:
Stephenson Oklahoma Cancer Center, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Christina Forest
Affiliation:
Stephenson Oklahoma Cancer Center, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
J. Spencer Thompson
Affiliation:
Stephenson Oklahoma Cancer Center, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Salahuddin Ahmad
Affiliation:
Stephenson Oklahoma Cancer Center, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Terence Herman
Affiliation:
Stephenson Oklahoma Cancer Center, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
Carl Bogardus
Affiliation:
Stephenson Oklahoma Cancer Center, Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
*
Correspondence to: Chance Matthiesen, MD, Stephenson Oklahoma Cancer Center, 800 N.E. 10th Street, OKCC L100, Oklahoma City, OK 73104, USA. Tel: 405-271-3016; Fax: 405-271-9240. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background: The role of radiotherapy for large and locally advanced non-melanoma skin cancer is unclear. In this report, we aimed to review our institutional experience with patients treated with radiation therapy for T2–T4 NMSC and analyze outcomes.

Methods: Seventy patients and 85 lesions were reviewed who received radiotherapy. Fifty-six lesions (65.9%) were untreated, 17 (20.0%) recurrent, and 12 (14.1%) post-operative. Forty-three (50.6%) were staged T2, 20 (23.5%) T3, and 22 (25.9%) T4. Median follow-up was 20 months.

Results: Thirty-nine living patients (59.0%) had no evidence of disease, of which 35 (89.7%) required no therapy following radiotherapy. Twenty-seven patients (41.0%) died, of which 10 deaths were attributed to disease progression. Achievement of complete response (CR) to all therapy and radiotherapy alone was, respectively, 95.3% and 86% for T2, 70% and 65% for T3, and 68.2% and 59.1% for T4. Statistically significant factors for CR included basal cell histology (p = 0.005) and tumour stage T2 (0.01).

Conclusions: Radiotherapy for T2–T4 NMSC is effective. Basal cell histology and T2 are statistically favoured to achieve CR to radiotherapy alone.

Keywords

Non-melanoma skin cancerradiotherapyIMRT
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 12 , Issue 1 , March 2013 , pp. 56 - 65
Copyright
Copyright © Cambridge University Press 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Miller, SJ, Alam, M, Andersen, J, Berg, D, Bichakjian, CK, Bowen, G, Cheney, RT, Glass, LF, Grekin, RC, Kessinger, A, Lee, NY, Liegeois, N, Lydiatt, DD, Michalski, J, Morrison, WH, Nehal, KS, Nelson, KC, Nghiem, P, Olencki, T, Perlis, CS, Rosenberg, EW, Shaha, AR, Urist, MM, Wang, LC, Zic, JA. Basal cell and squamous cell skin cancers. J Natl Compr Canc Netw 2010; 8:836–864.Google Scholar
Halperin, EC, Perez, CA, Brady, LW. Perez and Brady’s principles and practice of radiation oncology, 5th edition. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2008.Google Scholar
Harrison, LB, Sessions, RB, Hong, WK. Head and neck cancer: A multidisciplinary approach, 3rd edition. Philadelphia: Lipppincott Williams & Wilkins; 2009.Google Scholar
Locke, J, Karimpour, S, Young, G, Lockett, MA, Perez, CA. Radiotherapy for epithelial skin cancer. Int J Radiat Oncol Biol Phys 2001; 51:748–755.Google Scholar
Tsao, MN, Tsang, RW, Liu, FF, Panzarella, T, Rotstein, L. Radiotherapy management for squamous cell carcinoma of the nasal skin: the Princess Margaret Hospital experience. Int J Radiat Oncol Biol Phys 2002; 52:973–979.Google Scholar
Wallace, A, Morris, CG, Kirwan, J, Amdur, RJ, Werning, JW, Mendenhall, WM. Radiotherapy for squamous cell carcinoma of the nasal vestibule. Am J Clin Oncol 2007; 30:612–616.Google Scholar
Ashby, MA, Smith, J, Ainslie, J, McEwan, L. Treatment of nonmelanoma skin cancer at a large Australian center. Cancer 1989; 63:1863–1871.Google Scholar
Papadopoulos, O, Frantzoglou, M, Chrisostomidis, C, Konofaos, P, Frangoulis, M, Barlas, G. Neglected squamous cell carcinoma of the frontal area: a clinical report. J Craniofac Surg 2006; 17:1015–1020.Google Scholar
Al-Othman, MO, Mendenhall, WM, Amdur, RJ. Radiotherapy alone for clinical T4 skin carcinoma of the head and neck with surgery reserved for salvage. Am J Otolaryngol 2001; 22:387–390.Google Scholar
Mendenhall, WM, Parsons, JT, Mendenhall, NP, Million, RR. T2-T4 carcinoma of the skin of the head and neck treated with radical irradiation. Int J Radiat Oncol Biol Phys 1987; 13:975–981.Google Scholar
Lee, WR, Mendenhall, WM, Parsons, JT, Million, RR. Radical radiotherapy for T4 carcinoma of the skin of the head and neck: a multivariate analysis. Head Neck 1993; 15:320–324.Google Scholar
Greene, FL. American Joint Committee on Cancer, American Cancer Society. AJCC cancer staging manual, 6th edition. New York: Springer-Verlag; 2002.Google Scholar
Chen, AM, Li, BQ, Farwell, DG, et al. Improved dosimetric and clinical outcomes with intensity modulated radiotherapy for head and neck cancer of unknown primary origin. Int J Radiat Oncol Biol Phys 2011; 79 (3): 756–762.Google Scholar
Bhide, SA, Nutting, CM. Advances in radiotherapy for head and neck cancer. Oral Oncol 2010; 46:439–441.Google Scholar
Edge, SB. American Joint Committee on Cancer. AJCC cancer staging manual, 7th edition. New York: Springer; 2010.Google Scholar