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Predictors of early vaginal stenosis during pelvic radiotherapy for locally advanced cervix cancer: a study from a tertiary cancer centre in Eastern India

Published online by Cambridge University Press:  02 March 2015

Aparna Gangopadhyay  and
Jaydip Biswas
Aparna Gangopadhyay*
Affiliation:
Department of Radiation Oncology, Chittaranjan National Cancer Institute, Kolkata, India
Jaydip Biswas
Affiliation:
Department of Medical Oncology, Chittaranjan National Cancer Institute, Kolkata, India
*
Correspondence to: Aparna Gangopadhyay, Department of Radiation Oncology, Chittaranjan National Cancer Institute, 377, M.B. Road, Panchanantala, Kolkata 700049, India. Tel: +91 983 638 6469. Fax: +91 332 541 0088. E-mail: [email protected]
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Abstract

Aim

To explore possible predictors of early vaginal stenosis among patients with locally advanced cervix cancer on pelvic chemoradiation.

Patients and methods

A total of 232 patients with locally advanced cervix cancer, who received pelvic radiotherapy at our institute from November 2011 to October 2013, were prospectively studied. Possible predictors chosen were age, tumour stage, initial vaginal involvement, concomitant chemotherapy and development of vaginitis of Radio Therapy Oncology Group grade 2 or more during radiotherapy. Multiple logistic regression was carried out to assess predictors and the relative risk of predictors was calculated.

Results

Initial vaginal involvement and addition of concomitant chemotherapy are predictors of early vaginal stenosis in locally advanced cervix cancer patients on pelvic chemoradiation. Relative risk for early vaginal stenosis with vaginal involvement at presentation was 16·31, whereas that for concomitant chemotherapy was 9·95.

Conclusion

Among patients with locally advanced cervix cancer receiving pelvic chemoradiation, two factors, namely, initial vaginal involvement and concomitant chemotherapy are predictive of early vaginal stenosis. Patients with these factors should be assessed at regular intervals for early vaginal stenosis during pelvic chemoradiation to assess the optimal timing of intracavitary brachytherapy. This is particularly of importance in the absence of facilities for interstitial brachytherapy to ensure appropriate target coverage.

Keywords

intracavitary brachytherapylocally advanced cervix cancervaginal stenosis
Type
Short Communication
Information
Journal of Radiotherapy in Practice , Volume 14 , Issue 2 , June 2015 , pp. 216 - 218
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Copyright
© Cambridge University Press 2015 

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