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Oral candidiasis: Species identification and their antifungal susceptibility pattern in cancer patients receiving radiation therapy

Published online by Cambridge University Press:  13 February 2012

Pratibha M. Mane  and
Y. Hyma Pratyusha
Pratibha M. Mane*
Affiliation:
Department of Microbiology, Government Medical College, Aurangabad, Maharashtra, India
Y. Hyma Pratyusha
Affiliation:
Department of Microbiology, Government Medical College, Aurangabad, Maharashtra, India
*
Correspondence to: Dr Pratibha M. Mane, MD, Assistant Professor of Microbiology, Mamata Medical College,Khammam, A.P. India. E-mail: [email protected]
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Abstract

Introduction: Radiotherapy-induced hyposalivation encourages oral Candida colonization that often leads to oral/pharyngeal candidiasis. The objective of this study was to identify the Candida species in lesions of oropharyngeal candidiasis in patients undergoing radiotherapy for head and neck cancers and to find out antifungal susceptibility pattern.

Material and methods: Swabs were collected from 60 patients who developed lesions suggestive of oral candidiasis at the end of 1st week of radiation therapy. Antifungal susceptibility of each of the isolated species was done using disc diffusion method following CLSI guidelines.

Results: Candida was isolated in 13 cases. C. albicans (7) was the most predominant species; a small number of other species have also been identified. Few strains (3) of Candida showed variable resistance to the commonly used antifungal drugs.

Discussion: The colonization of Candida may lead to development of infections with drug-resistant strains, and hence the patients receiving radiation for head and neck cancers should undergo microbiological study for oral candidiasis.

Keywords

Candidiasisradiotherapyantifungal drugs
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 12 , Issue 2 , June 2013 , pp. 100 - 104
Copyright
Copyright © Cambridge University Press 2012

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References

Worthington, HV, Clarkson, JE, Eden, OB. Interventions for preventing oral mucositis for patients with cancer receiving treatment (Review). Interventions for preventing oral candidiasis for patients with cancer receiving treatment (review). Cochrane Database Syst Rev 2007; 1:CD003807.Google Scholar
Lalla, RV, Latortue, MC, Hong, CH, Ariyawardana, A, D’Amato-Palumbo, S, Fischer, DJ, Martof, A, Nicolatou-Galitis, O, Patton, LL, Elting, LS, Spijkervet, FK, Brennan, MT; Fungal Infections Section, Oral Care Study Group, Multinational Association of Supportive Care in Cancer (MASCC)/International Society of Oral Oncology (ISOO). A systematic review of oral fungal infections in patients receiving cancer therapy. Support Care Cancer 2010; 18:985–992.CrossRefGoogle Scholar
Schelenz, S, Abdallah, S, Gray, G, Stubbings, H, Gow, I, Baker, P, Hunter, PR. Epidemiology of oral yeast colonization and infection in patients with hematological malignancies, head neck and solid tumors. J Oral Pathol Med 2011; 40:83–89.CrossRefGoogle ScholarPubMed
Koc, M, Aktas, E. Prophylactic treatment of mycotic mucositis in radiotherapy of patients with head and neck cancers. Jpn J Clin Oncol 2003; 33:57–60.CrossRefGoogle ScholarPubMed
Redding, SW, Zellars, RC, Kirkpatrick, WR, McAtee, RK, Caceres, MA, Fothergill, AW, Lopez-Ribot, JL, Bailey, CW, Rinaldi, MG, Patterson, TF. Epidemiology of oropharyngeal Candida colonization and infection in patients receiving radiation for head and neck cancer. J Clin Microbiol 1999; 37:3896–3900.CrossRefGoogle ScholarPubMed
Belazi, M, Velegraki, A, Koussidou-Eremondi, T, Andreadis, D, Hini, S, Arsenis, G, Eliopoulou, C, Destouni, E, Antoniades, D. Oral Candida isolates in patients undergoing radiotherapy for head and neck cancer: prevalence, azole susceptibility profiles and response to antifungal treatment. Oral Microbiol Immunol 2004; 19:347–351.CrossRefGoogle ScholarPubMed
Alberth, M, Majoros, L, Kovalecz, G, Borbás, E, SzegediI, J I, J, Márton, I, Kiss, C. Significance of oral Candida infections in children with cancer. Pathol Oncol Res 2006; 12:237–241.CrossRefGoogle ScholarPubMed
Dongari-Bagtzoglou, A, Dwivedi, P, Ioannidou, E, Shaqman, M, Hull, D, Burleson, J. Oral Candida infection and colonization in solid organ transplant recipients. Oral Microbiol Immunol 2009; 24:249–254.CrossRefGoogle ScholarPubMed
Nicolatou-Galitis, O, Velegraki, A, Sotiropoulou-Lontou, A, Dardoufas, K, Kouloulias, V, Kyprianou, K, Kolitsi, G, Skarleas, C, Pissakas, G, Papanicolaou, VS, Kouvaris, J. Effect of fluconazole antifungal prophylaxis on oral mucositis in head and neck cancer patients receiving radiotherapy. Support Care Cancer 2006; 14:44–51.CrossRefGoogle Scholar
Epstein, JB, Freilich, MM, Le, ND. Risk factors for oropharyngeal candidiasis in patients who receive radiation therapy for malignant conditions of the head and neck. Oral Surg Oral Med Oral Pathol 1993; 76:169–174.CrossRefGoogle ScholarPubMed
Jain, PA, Veerabhadrudu, K, Kulkarni, RD, Ajantha, GS, Shubhada, C, Amruthkishan, U. Comparative study of adherence of oral Candida albicans isolates from HIV sero-positive individuals and HIV sero-negative individuals to human buccal epithelial cells. Indian J Pathol Microbiol 2010; 53:513–517.CrossRefGoogle ScholarPubMed
Lattif, AA, Banerjee, U, Prasad, R, Biswas, A, Wig, N, Sharma, N, Haque, A, Gupta, N, Baquer, NZ, Mukhopadhyay, G. Susceptibility pattern and molecular type of species-specific Candida in oropharyngeal lesions of Indian human immunodeficiency virus-positive patients. J Clin Microbiol 2004; 42:1260–1262.CrossRefGoogle ScholarPubMed
González Gravina, H, González de Morán, E, Zambrano, O, Lozano Chourio, M, Rodríguez de Valero, S, Robertis, S, Mesa, L. Oral Candidiasis in children and adolescents with cancer. Identification of Candida spp. Med Oral Patol Oral Cir Bucal 2007; 12:E419–E423.Google ScholarPubMed
Sebti, A, Kiehn, TE, Perlin, D, Chaturvedi, V, Wong, M, Doney, A, Park, S, Sepkowitz, KA. Candida dubliniensis at a cancer center. Clin Infect Dis 2001; 32:1034–1038.CrossRefGoogle Scholar
Baradkar, VP, Kumar, S. Species identification of Candida isolates obtained from oral lesions of HIV infected patients. Indian J Dermatol 2009; 54:385–386.CrossRefGoogle ScholarPubMed
Chavasco, JK, Paula, CR, Hirata, MH, Aleva, NA, Melo, CE, Gambale, W, Ruiz Lda, S, Franco, MC. Molecular identification of Candida dubliniensis isolated from oral lesions of HIV-positive and HIV-negative patients in São Paulo, Brazil. Rev Inst Med Trop Sao Paulo 2006; 48:21–26.CrossRefGoogle ScholarPubMed
Eraso, E, Moragues, MD, Villar-Vidal, M, Sahand, IH, González-Gómez, N, Pontón, J, Quindós, G. Evaluation of the new chromogenic medium Candida ID 2 for isolation and identification of Candida albicans and other medically important Candida species. J Clin Microbiol 2006; 44:3340–3345.CrossRefGoogle ScholarPubMed
Abraham, CM. Advances and emerging techniques in the identification, diagnosis and treatment of Oral Candidiasis. The Open Pathol J 2011; 5:8–12. DOI: 10.2174/1874375701105010008.CrossRefGoogle Scholar
Liguori, G, Lucariello, A, Colella, G, De Luca, A, Marinelli, P. Rapid identification of Candida species in oral rinse solutions by PCR. J Clin Pathol 2007; 60:1035–1039.CrossRefGoogle ScholarPubMed
Das, S, Brown, TM, Kellar, KL, Holloway, BP, Morrison, CJ. DNA probes for the rapid identification of medically important Candida species using a multianalyte profiling system. FEMS Immunol Med Microbiol 2006; 46:244–250.CrossRefGoogle ScholarPubMed
Chakrabarti, A, Ghosh, A, Kanta, A, Kumar, P. In vitro antifungal susceptibility of Candida. Indian J Med Res 1995; 102:13–19.Google ScholarPubMed