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A novel approach to assess mean lethal radiation dose with water proton spin lattice relaxation times

Published online by Cambridge University Press:  12 November 2010

Syed F. Akber  and
Than S. Kehwar
Syed F. Akber
Affiliation:
Department of Radiation Oncology, Case Western Reserve University, Cleveland, Ohio, USA
Than S. Kehwar*
Affiliation:
Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC Cancer Centers, Pennsylvania, USA
*
Correspondence to: Than S. Kehwar, Department of Radiation Oncology, University of Pittsburgh Cancer Institute, UPMC St. Margaret Hospital, Pittsburgh, PA 15215. E-mail: [email protected]
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Abstract

The assessment of mean lethal radiation dose (D0) in human organs, using multi-target and linear quadratic models, with water proton nuclear magnetic resonance spin lattice relaxation time yields a correlation coefficient of 0.90 and 0.82, respectively. Results of this study reveal that as the spin lattice relaxation time increases, the D0 decreases.

Keywords

Mean lethal radiation dosesproton spin lattice relaxation timesmulti-target modellinear quadratic model
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 10 , Issue 2 , June 2011 , pp. 117 - 119
Copyright
Copyright © Cambridge University Press 2010

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References

Akber, SF. Water proton relaxation times of pathological tissues. Physiol Chem Phys Med NMR 2008; 40:1–42.Google ScholarPubMed
Akber, SF. Is spin lattice relaxation time independent of species?. Med Hypotheses 1996; 47:101–105.CrossRefGoogle ScholarPubMed
Akber, SF. Organ weight: a new tissue parameter to assess water proton spin-lattice relaxation time. Med Hypotheses 1997; 48:71–75.CrossRefGoogle ScholarPubMed
Akber, SF. Correlation of radiation tolerance dose of normal human organs with organ weight, blood, and water content. Am J Clin Oncol 2000; 23:345–348.CrossRefGoogle ScholarPubMed
Akber, SF, Kehwar, TS. Correlation between mean lethal dose and organ weight. J Radioth Pract 2009; 8:163–164.CrossRefGoogle Scholar
Cohen, L. Biophysical models in radiation oncology. CRC publication, 1983.Google Scholar
Cohen, L. The best find values of mean lethal radiation dose for skin, spine, lung, gut. Personal Communication, 1997.Google Scholar
Damadian, R, Zaner, K, Hor, D, DiMaio, T. Human tumors detected by nuclear magnetic resonance. Proc Natl Acad Sci USA 1974; 71:1471–1473.CrossRefGoogle ScholarPubMed