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Multi-modality management of extraosseous Ewing sarcoma: 10-year experience from a tertiary care centre

Published online by Cambridge University Press:  10 March 2020

Arvind Sathyamurthy Open the ORCID record for Arvind Sathyamurthy [Opens in a new window] ,
Ashish Singh ,
Tarun Jose ,
Patricia Sebastian ,
Rajesh Balakrishnan ,
Anne Jennifer Prabhu  and
Selvamani Backianathan
Arvind Sathyamurthy
Affiliation:
Department of Radiation Oncology, Ida B Scudder Cancer Centre, Christian Medical College, Vellore, Tamil Nadu, India
Ashish Singh*
Affiliation:
Department of Medical Oncology, Christian Medical College, Vellore, Tamil Nadu, India
Tarun Jose
Affiliation:
Department of Radiation Oncology, Ida B Scudder Cancer Centre, Christian Medical College, Vellore, Tamil Nadu, India
Patricia Sebastian
Affiliation:
Department of Radiation Oncology, Ida B Scudder Cancer Centre, Christian Medical College, Vellore, Tamil Nadu, India
Rajesh Balakrishnan
Affiliation:
Department of Radiation Oncology, Ida B Scudder Cancer Centre, Christian Medical College, Vellore, Tamil Nadu, India
Anne Jennifer Prabhu
Affiliation:
Department of Pathology, Christian Medical College, Vellore, Tamil Nadu, India
Selvamani Backianathan
Affiliation:
Department of Radiation Oncology, Ida B Scudder Cancer Centre, Christian Medical College, Vellore, Tamil Nadu, India
*
Author for correspondence: Ashish Singh, Associate Professor, Department of Medical Oncology, Christian Medical College, Vellore, Tamil Nadu, India. E-mail: [email protected]
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Abstract

Aim:

To analyse the presentation, diagnosis and patterns of care of extraosseous Ewing sarcoma treated at our institution between 2008 and 2018.

Methods:

Electronic medical records of extraosseous Ewing sarcoma patients treated at our institution between January 2008 and April 2018 were reviewed. Kaplan–Meier curves were plotted to assess the overall and disease-free survival with 95% confidence intervals. A univariate analysis was carried out to assess the impact of variables such as surgical excision, completeness of surgery, completeness of chemotherapy and addition of radiation therapy on the survivorship.

Results:

The records of 65 patients treated at our institution were available for review. The mean age was 26·4 years. The most frequent sites of extraosseous Ewing tumour were kidney—9/65 (13·8%) and brain—10/65 (15·4%). Sixteen (24·6%) patients presented with inoperable/metastatic disease at diagnosis. The other 49 (75·4%) had localised disease at presentation. The median overall survival of the 49 non-metastatic patients was 46 months, and the disease-free survival was 45 months.

Conclusion:

Extraosseous Ewing sarcoma is a rare and aggressive tumour diagnosed by molecular techniques. Multi-modality treatment including surgical resection with wide margins, adjuvant radiation when indicated and completion of systemic chemotherapy results in optimum outcomes.

Keywords

extraosseous Ewing sarcomamulti-modality managementradiotherapyimmunohistochemical diagnosispatterns of care
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 20 , Issue 2 , June 2021 , pp. 189 - 195
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Copyright
© The Author(s), 2020. Published by Cambridge University Press

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