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Management of cancerisation of the lobules with pre-invasive or invasive breast carcinoma: a case series

Published online by Cambridge University Press:  01 December 2008

Federico Ampil ,
Fleurette Abreo ,
Benjamin Li ,
Roxana Baluna ,
Gary Burton  and
Quyen Chu
Federico Ampil*
Affiliation:
Department of Radiology, Louisiana State University Health Sciences Center and Feist-Weiller Cancer Center, Shreveport, Louisiana, USA
Fleurette Abreo
Affiliation:
Department of Pathology, Louisiana State University Health Sciences Center and Feist-Weiller Cancer Center, Shreveport, Louisiana, USA
Benjamin Li
Affiliation:
Department of Surgery, Louisiana State University Health Sciences Center and Feist-Weiller Cancer Center, Shreveport, Louisiana, USA
Roxana Baluna
Affiliation:
Department of Radiology, Louisiana State University Health Sciences Center and Feist-Weiller Cancer Center, Shreveport, Louisiana, USA
Gary Burton
Affiliation:
Department of Medicine, Louisiana State University Health Sciences Center and Feist-Weiller Cancer Center, Shreveport, Louisiana, USA
Quyen Chu
Affiliation:
Department of Surgery, Louisiana State University Health Sciences Center and Feist-Weiller Cancer Center, Shreveport, Louisiana, USA
*
Correspondence to: Federico Ampil, Division of Therapeutic Radiology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LS 71130, USA. E-mail: [email protected]
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Abstract

Cancerisation of the lobules (CL), the intra-luminal extension of carcinoma from ducts and ductules into the breast lobules, is not often encountered in clinical practice. A retrospective study of eight individuals diagnosed with CL and ductal carcinoma in situ (DCIS) or cancer of the breast between 1999 and 2006 was undertaken to determine the management of the disease and patient outcomes. In most cases, breast conservation surgery with postoperative radiotherapy or mastectomy and systemic therapy were the chosen methods of treatment. None of the patients experienced tumour relapse or progression during a mean follow-up period of 40.6 (range 8–90) months. The management philosophy for this particular neoplastic condition should be based on the understanding that CL, when detected with DCIS or invasive breast cancer, may represent more extensive disease. Moreover, the finding of such histopathology underlines the need for meticulous attention to the resection margins and additional treatment as indicated.

Keywords

Cancerisation of the lobulesbreast cancerradiotherapymastectomyductal carcinoma in situ
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 7 , Issue 4 , December 2008 , pp. 229 - 231
Copyright
Copyright © Cambridge University Press 2008

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