Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-27T17:35:06.324Z Has data issue: false hasContentIssue false
  • English
  • Français

IMRT in a rare case of bilateral optic nerve glioma

Published online by Cambridge University Press:  19 May 2020

Rashmi Singh Open the ORCID record for Rashmi Singh [Opens in a new window] ,
Anup Kumar ,
Rajanigandha Tudu ,
Payal Raina  and
Praveer Munda
Rashmi Singh*
Affiliation:
Department of Radiation Oncology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
Anup Kumar
Affiliation:
Department of Radiation Oncology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
Rajanigandha Tudu
Affiliation:
Department of Radiation Oncology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
Payal Raina
Affiliation:
Department of Radiation Oncology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
Praveer Munda
Affiliation:
Department of Radiation Oncology, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India
*
Author for correspondence: Dr Rashmi Singh, Radiation Oncology, Rajendra Institute of Medical Sciences, Oncology Block, Bariatu, Ranchi834009Jharkhand, India. Tel: +91 9999572340. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Purpose:

Optic nerve glioma (OPG) is a rare tumour of children and adolescents. The treatment is challenging as it may jeopardise the visual outcome. We are reporting a case of bilateral OPG, treated with intensity-modulated radiotherapy in our department.

Material and Method:

An 18-year-old female presented with a gradually deteriorating vision in both eyes. A detailed clinical and ophthalmological examination was carried out. Her MRI of orbit and brain were suggestive of bilateral optic nerve glioma. She was treated with intensity-modulated radiotherapy to a total dose of 54Gy in 30 fractions over 6 weeks.

Results:

She well tolerated the treatment. Post radiotherapy at 8 weeks, she had stabilization of vision on clinical assessment.

Conclusion:

Radiotherapy using IMRT can be successfully used to treat OPG, and it checks tumour growth and prevents further deterioration.

Keywords

IMRToptic nerve gliomaradiotherapy
Type
Case Study
Information
Journal of Radiotherapy in Practice , Volume 20 , Issue 1 , March 2021 , pp. 120 - 122
Check for updates
Copyright
© The Author(s), 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Heideman, RL, Packer, RJ, Albright, LA, Freeman, CR, Rorke, LB. Tumors of the central nervous. In: Pizzo P, Poplack D (ed) Principles and practice of pediatric oncology. Philadelphia (PA): Lippincott-Raven; 1997: 633–697Google Scholar
Alvord, EC Jr, Lofton, S. Gliomas of the optic nerve or chiasm: Outcome by patient’s age, tumour site, and treatment. J Neurosurg 1988; 68:85–98.CrossRefGoogle ScholarPubMed
Campen, CJ, Gutmann, DH. Optic pathway gliomas in neurofibromatosis type 1. J Child Neurol 2018; 33 (1): 73–81.CrossRefGoogle ScholarPubMed
Tao, ML, Barnes, PD, Billett, AL, Leong, TS. Childhood optic chiasm gliomas: radiographic response following radiotherapy and long- term clinical outcome. Int J Radiat Oncol Biol Phys 1997; 39: 579–587.CrossRefGoogle ScholarPubMed
Nancy, J, Tarbell, PD. In Office Practice of Neurology (2nd Edition) 2003.Google Scholar
Jenkin, D, Angyalfi, S, Becker, L, Berry, M. Optic glioma in children: Surveillance, resection, or irradiation? Int J Radiat Oncol Biol Phys 1993; 25: 215–225.Google Scholar
Flickinger, JC, Torres, C, Deutsch, M. Management of low-grade gliomas of the optic nerve and chiasm. Cancer 1988; 61: 635–642.3.0.CO;2-2>CrossRefGoogle ScholarPubMed
Grabenbauer, G, Schuchardt, U, Buchfelder, M, Rödel, CM. Radiation therapy of optico-hypothalamic gliomas (OHG)–radiographic response, vision and late toxicity. Radiother Oncol 2000; 54: 239–245.CrossRefGoogle Scholar
Janss, AJ, Grundy, R, Cnaan, A, Savino, PJ. Optic pathway an hypothalamic/chiasmatic glioma in children younger than age 5 years with a 6-year follow-up. Cancer. 1995; 75: 1051–1059.3.0.CO;2-S>CrossRefGoogle ScholarPubMed
Combs, S, Schulz, D, Moschos, D, Thilmamm, C. Fractionated stereotactic radiotherapy of optic pathway gliomas: tolerance and long-term outcome. Int J Radiat Oncol Biol Phys 2005; 62: 814–819.CrossRefGoogle ScholarPubMed
Kelly, JP, Leary, S, Khanna, P, Weiss, AH. Longitudinal measures of visual function, tumor volume, and prediction of visual outcomes after treatment of optic pathway gliomas. Ophthalmology. 2012; 119(6): 1231–1237.CrossRefGoogle ScholarPubMed