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Correlation of six-minute walk test, pulmonary function test and radiation pneumonitis in the management of carcinoma of oesophagus: A prospective pilot study

Published online by Cambridge University Press:  16 November 2010

Sheh Rawat ,
Gaurav Kumar ,
Abhishek Puri ,
Manoj Kumar Sharma ,
Anjali Kakria  and
Pankaj Kumar
Sheh Rawat
Affiliation:
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
Gaurav Kumar*
Affiliation:
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
Abhishek Puri
Affiliation:
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
Manoj Kumar Sharma
Affiliation:
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
Anjali Kakria
Affiliation:
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
Pankaj Kumar
Affiliation:
Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India
*
Correspondence to: Gaurav Kumar, Rajiv Gandhi Cancer Institute and Research Centre, Sector 5, New Delhi, India. Tel: +91-11-47022222; Fax: +91-11-27051037; E-mail: [email protected]
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Abstract

Purpose: To correlate six-minute walk test (6MWT) and pulmonary function test (PFT) with incidence of radiation pneumonitis (RP) while treating patients with oesophageal cancer with conformal radiotherapy.

Methods: Forty-five patients were selected to the study protocol. Pulmonary evaluation was done objectively by chest x-ray (CXR), 6MWT and PFT and subjectively by symptoms of cough, dyspnoea and fatigue. These tests were performed before radiation and then repeated at 1, 3, 6 and 9 months after treatment. The dose-volume histogram (DVH) was used to derive doses received by lung and organs at risk. χ2-test was used for calculating the p value.

Results: The walk distance change (WDC) correlated with the changes in PFT values (p = 0.001) were done at 3 and 9 months after radiation, respectively. V30 values of ≥20% correlated with the incidence of acute pneumonitis (p = 0.007). 6MVT/vital capacity (VC) values of ≤4 ft/l had a correlation with the incidence of clinically symptomatic RP at 9 months.

Conclusion: 6MWT and PFT are supplementary to each other for assessing the lung function status; but their individual role in predicting RP is weak. However, they are complementary to each other in assessing the risk of radiation-induced lung dysfunction.

Keywords

Six-minute walk testpulmonary function testradiation pneumonitiscarcinoma of oesophagusdosimetric parameters
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 10 , Issue 3 , September 2011 , pp. 191 - 199
Copyright
Copyright © Cambridge University Press 2011

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