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Comparison of calculated and measured basic dosimetric parameters for total body irradiation with 6- and 18-MV photon beams

Published online by Cambridge University Press:  24 January 2020

Elham Hoseinnezhad ,
Ghazale Geraily Open the ORCID record for Ghazale Geraily [Opens in a new window] ,
Mahbod Esfahani ,
Mostafa Farzin  and
Somayeh Gholami
Elham Hoseinnezhad
Affiliation:
Department of Medical Physics and Medical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Ghazale Geraily*
Affiliation:
Department of Medical Physics and Medical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Radiation Oncology Research Centre, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Mahbod Esfahani
Affiliation:
Radiation Oncology Research Centre, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
Mostafa Farzin
Affiliation:
Radiation Oncology Research Centre, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
Somayeh Gholami
Affiliation:
Radiation Oncology Research Centre, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
*
Author for correspondence: Geraily Ghazale, Department of Medical Physics and Medical Engineering, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. E-mail: [email protected]
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Abstract

Purpose:

Total body irradiation (TBI) is an external beam radiation therapy in which large field size and extended source skin distances (SSDs) are applied to deliver a therapeutic dose to the whole body. As measurements in such situations are not common and have more uncertainties in comparison to standard dosimetry situations, it is more precise if calculated beam data can be used instead of measurements taken under TBI situations. The purpose of this study is to compare calculated beam data [percentage depth dose (PDD) and dose rate] with those obtained from simulated treatment measurements.

Materials and methods:

PDD and dose rates were measured for the 6- and 18-MV photon beams under TBI and standard conditions using 9,000 cm3 water phantom and ion chambers (Markus and Farmer). The results were then compared with the calculated PDD and dose rate data. The beam flatness was also measured under TBI and standard conditions for both 6- and 18-MV photon beams, and the results were then compared.

Results:

A comparison of the measurement and calculated beam data shows that the difference between calculated and measured PDD values is −6·97 and −4·14% for the 6- and 18-MV photon beams, respectively. The ratio of calculated to measured dose rate was 1·09 and 1·02 for the 6- and 18-MV photon beams, respectively. The beam flatness under TBI conditions was 4·59% for 6-MV and 5·37% for 18-MV photon beam, whereas under standard conditions, these values were 1·50 and 1·98% for 6- and 18-MV radiation beams, respectively.

Findings:

According to the results, due to a high error level in dose rate and PDD calculations, these parameters must be directly measured under TBI conditions; however, regarding the obtained results, direct measurement is not necessary for the 18-MV photon beam.

Keywords

beam flatnessdose ratedosimetrypercentage depth dosetotal body irradiation
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 20 , Issue 1 , March 2021 , pp. 66 - 70
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Copyright
© The Authors, 2020. Published by Cambridge University Press

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References

Giraud, P, Houle, A. Respiratory gating for radiotherapy: main technical aspects and clinical benefits. Bull Cancer 2010; 97 (7): 847–856.CrossRefGoogle ScholarPubMed
Akino, Y, Mcmullen, K P, Das, I J. Patterns of patient specific dosimetry in total body irradiation patterns of patient specific dosimetry in total body irradiation. Med Phys 2013; 40 (4): 041719.CrossRefGoogle ScholarPubMed
Allahverdi, M, Geraily, G, Esfahani, M, Sharafi, A, Haddad, P, Shirazi, A. Dosimetry and verification of 60Co total body irradiation with human phantom and semiconductor diode. J Med Phys 2007; 32 (4): 169–174.CrossRefGoogle Scholar
Rossi, E. Dosimetric characterization of GafChromic EBT3 films in Volumetric Modulated Arc Therapy (VMAT) radiotherapy treatments. Alma Mater Studiorum Universitá di Bologna, 2017.Google Scholar
Allahverdi, M, Geraily, G, Esfehani, M, Sharafi, A, Haddad, P, Shirazi, A. Dose homogeneity of total body irradiation for 60CO confirmed with diode dosimeter. Radiat Oncol 2007; 84: s136–s136.Google Scholar
Sarradin, V, Simon, L, Huynh, A, Gilhodes, J, Filleron, T, Izar, F. Total body irradiation using helical tomotherapy: treatment technique, dosimetric results and initial clinical experience [Utilisation de la Tomothérapie hélicoïdale pour l ’ irradiation corporelle totale : technique de traitement, résultats dosimétriques, et expérience clinique initiale]. Cancer Radiother 2018; 22 (1): 17–24.CrossRefGoogle Scholar
Galvin, J M, D’angio, G J, Walsh, G. Use of tissue compensators to improve the dose uniformity for total body irradiation. Int J Radiat Oncol Biol Phys 1980; 6 (6): 767–771.CrossRefGoogle ScholarPubMed
Leer, J W H, Broersel, J J, Vroomel, H De, Chinl, A, Noordijkl, E M, Dutreix, A. Techniques applied for total body irradiation. Radiot Oncol 1990; 18 (1): 10–5.CrossRefGoogle ScholarPubMed
Jahnke, A, Jahnke, L, Molina-Duran, F et al. Arc therapy for total body irradiation – a robust novel treatment technique for standard treatment rooms. Radiot Oncol 2014; 110 (3): 553–557.CrossRefGoogle ScholarPubMed
Lu, L, Filippi, J, Patel, A et al. A clinical dosimetry analysis of total body irradiation for leukemia patients. Med Phys 2014; 3 (1): 31–42.Google Scholar
Yao, R, Bernard, D, Turian, J et al. A simplified technique for delivering total body irradiation (TBI) with improved dose homogeneity. Med Phys 2012; 39 (4): 2239–2248.CrossRefGoogle ScholarPubMed
Shahzadeh, S, Gholami, S, Aghamiri, S M R, Mahani, H, Nabavi, M, Kalantari, F. Evaluation of normal lung tissue complication probability in gated and conventional radiotherapy using the 4D XCAT digital phantom. Comput Biol Med 2018; 97: 21–29.CrossRefGoogle ScholarPubMed
Wills, C, Cherian, S, Yousef, J, Wang, K, Mackley, H B. Total body irradiation: a practical review. Appl Radiat Oncol 2016; 2 (June): 11–17.Google Scholar
Nelligan, R, Bailey, M, Tran, T. ACPSEM ROSG TBI working group recommendations for quality assurance in total body irradiation International Commission on Radiation Units. Australas Phys Eng Sci Med 2015; 38: 205–215.10.1007/s13246-015-0344-7CrossRefGoogle Scholar
Zhang, M, Qin, N, Jia, X et al. Investigation on using high-energy proton beam for total body irradiation (TBI). 2016; 17 (4): 1–9.Google Scholar
Wolden, S L, Rabinovitch, R A, Bittner, N H J et al. American College of Radiology (ACR) and American Society for Radiation Oncology (ASTRO) Practice Guideline for the Performance of Total Body Irradiation (TBI). 2013; 36 (1): 97–101.Google Scholar
Houdek, P V, Pisciotta, V J. A comparison of calculated and measured data for total body irradiation by 10 MV x-rays. Phys Med Biol 1987; 32 (9): 1101–1108.CrossRefGoogle ScholarPubMed
Spunei, M, Mihai, M, Mălăescu, I. Experimental results in percentage depth dose. Rom Rep Phys 2013; 66 (1): 157–165.Google Scholar
Van Dyk, J, Galvin, J M, Glasgow, G P, Podgorsak, E B. AAPM REPORT NO. 17: the physical aspects of total and half body photon irradiation. Radiation therapy committee task group #29. American Association of Physicists in Medicine by the American institute of Physics, 1986.Google Scholar
Osei, J E. Validation of calculated Tissue Maximum Ratio (TMR) obtained from measured Percentage Depth Dose (PPD) data for high energy photon beam (6 MV and 15 MV). Master of Philosophy in Medical Physics. Ghana: University Of Ghana, 2017.Google Scholar
Khan, F M, Gibbons, J P. The Physics of Radiation Therapy, 5th edition. Philadelphia, PA: Lippincott Williams & Wilkins, 2014: 624 p Google ScholarPubMed
Izewska, J, Rajan, G. Radiation Oncology Physics: a Handbook for Teachers and Students. In: Podgorsak, E B (ed). Vienna: International Atomic Energy Agency; 2005: 657 p.Google Scholar
Li, D-Z, Kong, P-Y, Sun, J-G et al. Comparison of total body irradiation before and after chemotherapy in pretreatment for hematopoietic stem cell transplantation. Cancer Biother Radiopharm 2012; 27 (2): 119–123.CrossRefGoogle ScholarPubMed