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Comparative dosimetric analysis of whole abdominal radiotherapy with VMAT versus 3D conformal in patients with Wilms tumour

Published online by Cambridge University Press:  15 February 2019

Alejandro Olmos Open the ORCID record for Alejandro Olmos [Opens in a new window] ,
Alejandro Rodriguez ,
Estefania Beltran ,
Onix Garay ,
Armando Felix ,
Mario Alberto Ponce ,
Maurico Salcedo ,
Teresa Apresa ,
Lorena Lio  and
Martha Guzman
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Alejandro Olmos*
Affiliation:
Oncology Hospital, Radiotherapy Department, National Medical Center XXI Century, Mexican Social Security Institute, México City, Mexico
Alejandro Rodriguez
Affiliation:
Oncology Hospital, Radiotherapy Department, National Medical Center XXI Century, Mexican Social Security Institute, México City, Mexico
Estefania Beltran
Affiliation:
Oncology Hospital, Radiotherapy Department, National Medical Center XXI Century, Mexican Social Security Institute, México City, Mexico
Onix Garay
Affiliation:
Oncology Hospital, Radiotherapy Department, National Medical Center XXI Century, Mexican Social Security Institute, México City, Mexico
Armando Felix
Affiliation:
Oncology Hospital, Radiotherapy Department, National Medical Center XXI Century, Mexican Social Security Institute, México City, Mexico
Mario Alberto Ponce
Affiliation:
Oncology Hospital, Radiotherapy Department, National Medical Center XXI Century, Mexican Social Security Institute, México City, Mexico
Maurico Salcedo
Affiliation:
Oncology Hospital, Radiotherapy Department, National Medical Center XXI Century, Mexican Social Security Institute, México City, Mexico
Teresa Apresa
Affiliation:
Oncology Hospital, Radiotherapy Department, National Medical Center XXI Century, Mexican Social Security Institute, México City, Mexico
Lorena Lio
Affiliation:
Oncology Hospital, Radiotherapy Department, National Medical Center XXI Century, Mexican Social Security Institute, México City, Mexico
Martha Guzman
Affiliation:
Oncology Hospital, Radiotherapy Department, National Medical Center XXI Century, Mexican Social Security Institute, México City, Mexico
Fatima Chilaca
Affiliation:
Oncology Hospital, Radiotherapy Department, National Medical Center XXI Century, Mexican Social Security Institute, México City, Mexico
*
Author for correspondence: Alejandro Olmos, Oncology Hospital, Radiotherapy Department, National Medical Center XXI Century, Mexican Social Security Institute, México City, Mexico, Cuauthemoc 330, Col Doctores, Ciudad de Mexico, Ciudad de Mexico, 06720. (E-mail: [email protected])
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Abstract

Introduction

In this study, we undertake a dosimetric comparison of whole abdominal treatment plans of patients diagnosed with stage 3 Wilms tumour, to assess the benefits of treating these patients with volumetric arch therapy (VMAT) versus 3D conformal radiotherapy.

Material and methods

A retrospective study was undertaken on 23 patients receiving either VMAT or 3D conformal radiotherapy during 2013–2017. A dosimetric comparison was undertaken for both techniques, measuring planning target volume (PTV), conformity index (CI), homogeneity index (HI) and organs at risk (OAR).

Results

The dosimetric parameters for the PTV dose in the VMAT and 3D conformal technique showed no statistical difference (1,289·17 cGy versus 1,357·13 cGy, respectively, p=0·404). However, the VMAT technique had a better CI (1·04 VMAT versus 1·26 3D, p=0·004), and there was little difference in the HI (1·13 VMAT versus 1·15 3D, p=0·1606). In the statistical analysis, the decrease in dose to OAR for the VMAT technique is statistically significant for doses to lung and kidney (p=0·011 and p=0·002, respectively). Between the two techniques, there was no statistical significance in dose difference to the other OAR.

Conclusion

This work proposes using the VMAT technique in whole abdominal irradiation to improve conformity, without affecting the quality of the PTV coverage, when compared with the 3D conformal technique. In addition, VMAT reduces the doses to OAR such as the remaining kidney and lungs that are important to preserve to reduce the probability of radiation toxicity in these patients.

Keywords

3D conformal radiotherapyVMATWilms tumourwhole abdomen radiotherapy
Type
Technical Note
Information
Journal of Radiotherapy in Practice , Volume 18 , Issue 3 , September 2019 , pp. 301 - 303
Copyright
© Cambridge University Press 2019 

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Footnotes

Cite this article: Olmos A, Rodriguez A, Beltran E, Garay O, Felix A, Ponce MA, Salcedo M, Apresa T, Lio L, Guzman M, Chilaca F. (2019) Comparative dosimetric analysis of whole abdominal radiotherapy with VMAT versus 3D conformal in patients with Wilms tumour. Journal of Radiotherapy in Practice18: 301–303. doi: 10.1017/S1460396918000778

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