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Breast conservation surgery and radiation for a patient with synchronous primary breast cancers and BRCA1/BRCA2 positivity: is mastectomy required?

Published online by Cambridge University Press:  18 March 2011

Mark Trombetta ,
Katherine Kotinsley  and
Thomas B. Julian
Mark Trombetta*
Affiliation:
Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA Drexel University College of Medicine, Department of Radiation Oncology, Allegheny Campus, Pittsburgh, Pennsylvania, USA
Katherine Kotinsley
Affiliation:
Department of Radiation Oncology, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA
Thomas B. Julian
Affiliation:
Department of Human Oncology; Allegheny General Hospital, Pittsburgh, Pennsylvania, USA Drexel University College of Medicine, Department of Surgery, Allegheny Campus, Pittsburgh, Pennsylvania, USA
*
Correspondence to: Mark Trombetta, Department of Radiation Oncology, Allegheny General Hospital, 320 East North Avenue, Pittsburgh, Pennsylvania 15212, USA. E-mail: [email protected]
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Abstract

The role of breast conservation in patients expressing BRCA1 and BRCA2 genetic mutations is controversial. A patient who was found to have bilateral synchronous breast cancers and expressed a BRCA genetic mutation was recently evaluated. The patient had a strong desire for breast preservation. This case and a review of the pertinent literature are presented to discuss the role of breast conservation and radiation in patients with BRCA1 or BRCA2 genetic mutations.

Keywords

BRCA1BRCA2RadiationMastectomyBreast Conservation
Type
Case Study
Information
Journal of Radiotherapy in Practice , Volume 11 , Issue 1 , March 2012 , pp. 62 - 65
Copyright
Copyright © Cambridge University Press 2012

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