Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-18T04:36:15.336Z Has data issue: false hasContentIssue false

Automatic matching using intraprostatic calcifications as a volume of interest in CBCT images during prostate radiotherapy: a comparative study

Published online by Cambridge University Press:  19 July 2019

P. O’Connor*
Affiliation:
Cancer Centre, Radiotherapy Department, Royal Stoke University Hospital, Stoke on Trent, Staffordshire, UK
K. Barker
Affiliation:
Cancer Centre, Radiotherapy Department, Royal Stoke University Hospital, Stoke on Trent, Staffordshire, UK
*
Author for correspondence: P. O’Connor, Cancer Centre, Radiotherapy Department, Royal Stoke University Hospital, Stoke on Trent, Staffordshire ST4 6QG, UK. E-mail: Paul.O’[email protected]

Abstract

Aim:

The study aimed to assess the clinical feasibility of employing an automatic match during cone beam computed tomography (CBCT) imaging using prostatic calcifications within the 95% isodose set as the region of interest.

Materials and methods:

CBCT images were analysed on the 5th fraction in 34 patients evaluating the difference between standard manual soft tissue anatomy matching versus auto calcification matching. An assessment of the clinical feasibility of using prostatic calcifications during matching alongside considering the effect a more automated matching process has been conducted on interobserver variability.

Results:

The standard deviation values of the difference between the soft tissue match (baseline) versus automatic calcification matches fluctuated around 1 mm in all three axes for all of the matches carried out. The interobserver variability observed between the two radiographers was 0·055, 0·065 and 0·045 cm in the vertical, longitudinal and lateral axes, respectively.

Findings:

The clarity of the calcifications on the CBCT images might explain the low interobserver variability displayed by the two matching radiographers. A calcification provides a clear starting point for image matching before commencing a check of volumetric coverage, if the matching process begins in the same place, it can allow for a standardisation of matching technique between radiographers.

Type
Original Article
Copyright
© Cambridge University Press 2019

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Masson, S, Persad, R, Bahl, A.HDR brachytherapy in the management of high risk prostate cancer. Adv Urol 2012; 2012: 363370.CrossRefGoogle ScholarPubMed
Khoo, V.Radiotherapeutic techniques for prostate cancer, dose escalation and brachytherapy. Clin Oncol 2005; 17: 560571.CrossRefGoogle ScholarPubMed
Al-Mamgani, A, Heemsbergen, W, Levendag, PC. Subgroup analysis of patients with localised prostate cancer treated within a Dutch randomised dose escalation trial. Radiother Oncol 2010; 96: 813.CrossRefGoogle Scholar
Dearnaley, D, Sydes, M, Graham, J.Escalated dose versus standard dose conformal radiotherapy in prostate cancer: first results from the MRC RTO1 randomised controlled trial. Lancet Onco 2007; 8: 875887.Google Scholar
Yang, H, Huang, K, Wang, C.Prostate calcification worsen lower urinary tract symptoms in middle aged men. Urology 2013; 81: 13201324.CrossRefGoogle ScholarPubMed
Suh, J, Gardner, J, Kee, K.Calcifications in prostate and ejaculatory system: a study on 298 consecutive whole mount sections of prostate from radical prostatectomy or cystoprostatectomy specimens. Ann Diagn Pathol 2008; 12: 165170.CrossRefGoogle ScholarPubMed
Zeng, G, McGowan, T, Larsen, T. Calcifications are potential surrogates for prostate localisation in image guided radiotherapy. Int J Radiation Oncol Biol Phys 2008; 72: 963966.CrossRefGoogle Scholar
Hanna, S, Pimenta, W, Marta, G.Role of intra or periprostatic calcifications in image guided radiotherapy for prostate cancer. Genitourinary cancer. Int J Radiation Oncol Biol Phys 2012; 82: 12081216.CrossRefGoogle ScholarPubMed
Sbai, A, Thariat, J, Tachfouti, N.Intraprostatic calcifications as natural fiducial markers in image guided radiotherapy for prostate cancer. Cancer Radiotherapy 2014; 18: 740774.CrossRefGoogle ScholarPubMed