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Accelerated hypofractionated radiotherapy for advanced lung cancer

Published online by Cambridge University Press:  27 June 2017

Christina Armpilia ,
Andriani Harpidou ,
Zoi Kalaitzi ,
Charilaos Tsapas ,
Sofia Tsagouli ,
Ioannis Gkiozos  and
Konstantinos Syrigos
Christina Armpilia*
Affiliation:
Medical School, Aretaieion Hospital, National and Kapodistrian University of Athens, Athens, Greece Radiation Therapy Department, Iatriko Medical Center, Athens, Greece
Andriani Harpidou
Affiliation:
Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital, Athens, Greece
Zoi Kalaitzi
Affiliation:
Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital, Athens, Greece
Charilaos Tsapas
Affiliation:
Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital, Athens, Greece
Sofia Tsagouli
Affiliation:
Oncology Unit, Iatriko Medical Center, Athens, Greece
Ioannis Gkiozos
Affiliation:
Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital, Athens, Greece
Konstantinos Syrigos
Affiliation:
Oncology Unit, Third Department of Medicine, University of Athens, Sotiria General Hospital, Athens, Greece
*
Correspondence to: Christina Armpilia, Aretaieion University Hospital, Vas.Sofias 76 Avenue, 11528 Athens, Greece. Tel: 0030 210 728 6267. E-mail: [email protected]
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Abstract

Introduction – purpose

The aim of this study is to review the results of applying a hypofractionated radiotherapy schedule for locally advanced inoperable lung cancer in patients who have received chemotherapy. Lung cancer and especially non-small-cell lung cancer is prone to accelerated repopulation and shorter treatment schedules in the form of accelerated radiotherapy have been shown to improve treatment outcome.

Patients – method

In total, 29 patients with inoperable lung cancer (stage II, IIIa,b, IV) were treated with accelerated hypofractionated 3D conformal radiotherapy. All patients received a dose of 55 Gy in 20 fractions (daily dose of 2·75 Gy). The median age was 65·5 years, 87% of patients had stage III–IV disease, 93% of patients received sequential chemotherapy with their radiotherapy. Median follow-up of patients was 36 months.

Results

The median overall survival from time of diagnosis was 16·5 months and the 1 year overall survival was 31%. Complications were present in 44·8% of the patients and the most common complication (20·7%) was pneumonitis alone. The complication rate was not significantly different according to histological type, stage, type of chemotherapy, presence of recurrence or death.

Conclusion

Although our study limitation is the small number of patients, these data suggest that the efficacy of this hypofractionated schedule could be considered as alternative option to the conventional regimen of 66 Gy given in 33 fractions.

Keywords

hypofractionationlung cancerradiotherapy
Type
Original Articles
Information
Journal of Radiotherapy in Practice , Volume 17 , Issue 1 , March 2018 , pp. 78 - 84
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Copyright
© Cambridge University Press 2017 

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