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Liposarcoma of the left hemithorax and implications of MDM2

Published online by Cambridge University Press:  28 May 2019

Michael Stolten Open the ORCID record for Michael Stolten [Opens in a new window] ,
Deepak Sahasrabudhe  and
Louis Constine
Michael Stolten*
Affiliation:
University of Rochester Medical Center, Rochester, USA
Deepak Sahasrabudhe
Affiliation:
University of Rochester Medical Center, Rochester, USA
Louis Constine
Affiliation:
University of Rochester Medical Center, Rochester, USA
*
Author for correspondence: Michael Stolten, E-mail: [email protected]
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Abstract

Background:

Use of molecular information to guide clinical management of thoracic liposarcoma following resection.

Case presentation:

We present a case of a large liposarcoma of the left hemithorax. Initial biopsy consistent with lipoma however following resection pathology showed well-differentiated liposarcoma. Clinical data and molecular information including MDM2 from the tumour were employed in decision making regarding subsequent adjuvant radiation therapy versus close observation.

Conclusion:

Improved molecular characterisation has increased the precision of histological diagnoses and prediction of outcomes for many cancers. These may continue to help guide and strengthen clinical decision making and recommendations as they pertain to adjuvant therapy versus observation in the case of this patient.

Keywords

adjuvant radiation therapyliposarcomaMDM2thorax
Type
Case Study
Information
Journal of Radiotherapy in Practice , Volume 18 , Issue 4 , December 2019 , pp. 397 - 399
Copyright
© Cambridge University Press 2019 

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