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Impact of loco-regional treatment including radiotherapy in patients presenting with metastatic breast cancer

Published online by Cambridge University Press:  10 May 2021

Budhi Singh Yadav Open the ORCID record for Budhi Singh Yadav [Opens in a new window] ,
Rubu Sunku  and
Divya Dahiya Open the ORCID record for Divya Dahiya [Opens in a new window]
Budhi Singh Yadav*
Affiliation:
Radiation Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Rubu Sunku
Affiliation:
Radiation Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
Divya Dahiya
Affiliation:
General Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India
*
Author for correspondence: Dr Budhi Singh Yadav, Radiation Oncology, Post Graduate Institute of Medical Education and Research, Chandigarh 91160012, India. E-mail: [email protected]
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Abstract

Background:

The impact of loco-regional treatment (LRT) with radiotherapy (RT) in patients presenting with metastatic breast cancer (MBC) has not been widely studied. The aim of this study was to review the treatment outcomes of LRT including RT in patients with MBC.

Materials and methods:

Patients who presented with MBC were included in this retrospective study. Analysis was undertaken to determine the difference in local disease control, overall survival (OS) and progression-free survival (PFS) with systemic treatment alone, surgery alone, surgery plus RT and RT alone with long-rank test. Multivariate analysis was done, using the cox regression for factors affecting PFS and OS.

Results:

From 2007 to 2014, data of 257 patients with MBC were collected. Totally, 185 patients received LRT and 72 did not. LRT was surgery plus RT, surgery only and RT only in 113, 47 and 25 patients, respectively. Cytotoxic chemotherapy and hormone therapy were received by 205 and 166 patients, respectively. Median follow-up was 36 months (6–120 months). PFS and OS at 3 years with and without LRT were 31% versus 6% (p < 0·001) and 41% versus 17% (p < 0·001), respectively. PFS at 3 years with surgery plus RT, RT alone and surgery was 40, 33 and 6%, respectively. OS at 3 years with surgery plus RT, RT alone and surgery was 50, 38 and 17%, respectively. Patients without LRT had worse PFS and OS, 6 and 17%, respectively. RT had significant impact on PFS and OS along with chemotherapy and hormone treatment.

Conclusion:

In patients with MBC, improved local control, PFS and OS were achieved with loco-regional RT. Loco-regional RT along with chemotherapy and hormones were significant factors for PFS and OS irrespective of surgery.

Keywords

chemotherapyloco-regional treatmentmetastatic breast cancerradiotherapysurgery
Type
Original Article
Information
Journal of Radiotherapy in Practice , Volume 21 , Issue 4 , December 2022 , pp. 466 - 471
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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