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Hyperbaric oxygen for long-term complications of radiation cystitis

Published online by Cambridge University Press:  04 November 2014

Carlos Ferreira ,
Frederico Reis ,
Tiago Correia ,
André Cardoso ,
Manuel Cerqueira ,
Martinho Almeida ,
Rui Prisco  and
Oscar Camacho
Carlos Ferreira*
Affiliation:
Department of Urology, Pedro Hispano Hospital, Matosinhos, Portugal
Frederico Reis
Affiliation:
Department of Urology, Pedro Hispano Hospital, Matosinhos, Portugal
Tiago Correia
Affiliation:
Department of Urology, Pedro Hispano Hospital, Matosinhos, Portugal
André Cardoso
Affiliation:
Department of Urology, Pedro Hispano Hospital, Matosinhos, Portugal
Manuel Cerqueira
Affiliation:
Department of Urology, Pedro Hispano Hospital, Matosinhos, Portugal
Martinho Almeida
Affiliation:
Department of Urology, Pedro Hispano Hospital, Matosinhos, Portugal
Rui Prisco
Affiliation:
Department of Urology, Pedro Hispano Hospital, Matosinhos, Portugal
Oscar Camacho
Affiliation:
Hyperbaric Medicine Unit, Pedro Hispano Hospital, Matosinhos, Portugal
*
Correspondence to: Carlos Ferreira, Department of Urology, Pedro Hispano Hospital, 4464-513 Senhora da Hora, Matosinhos, Portugal. Tel: +351 91 244 01 83. Fax: +351 229 980 071. E-mail: [email protected]
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Abstract

Introduction

Bladder complications may be seen in up to 12% of patients treated with pelvic irradiation. To report the long-term efficacy of hyperbaric oxygen therapy (HBOT) on radiation-induced cystitis.

Methods

We followed 70 patients diagnosed with radiation cystitis submitted to HBOT in our institution from 2007 to 2013. All patients answered a questionnaire documenting symptom severity pre-HBOT and at the end of the follow-up period using the Late Effects of Normal Tissues – Subjective, Objective, Management, Analytical (LENT-SOMA) scale. Our treatment protocol consisted of multiple sessions (median of 40) of 100% oxygen delivery in a multiplace hyperbaric chamber at 2·4 atm for 80 minutes.

Results

With a median follow-up of 55·5 (4–85) months, the success rate after the follow-up period in terms of haematuria resolution or improvement was 91·4%. The mean score of each subjective variable of LENT-SOMA scale (dysuria, frequency, haematuria, incontinence) were significantly lower after the follow-up period (p<0·05) with the exception of decreased stream (p=0·14). The sum of all subjective scores of LENT-SOMA scale was also significantly lower after the follow-up period (p<0·05). No serious complications were observed.

Conclusions

Our results highlight the safety and long-term benefits of HBOT on haemorrhagic radiation cystitis and other distressful bladder symptoms.

Keywords

Radiation cystitisHaematuriaHyperbaric Oxygen
Type
Original Articles
Information
Journal of Radiotherapy in Practice , Volume 14 , Issue 1 , March 2015 , pp. 18 - 26
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Copyright
© Cambridge University Press 2014 

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