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The Genetics of Phenylpyruvic Oligophrenia

A Contribution to the Study of the Influence of Heredity on Mental Defect

Published online by Cambridge University Press:  08 February 2018

George A. Jervis
George A. Jervis*
Affiliation:
From the Research Department of Letchworth Village, Thiells, New York
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Extract

Although considerable attention has been devoted during the past years to the problems of the influence of heredity on mental deficiency, no final conclusions have yet been reached. It appears well established at the present time, first, that in a large percentage of cases, variously estimated at from 40 to 80%, mental deficiency is significantly determined by genetic mechanisms, and second, that recessive genes seem to play a considerable role in such mechanisms (Lokay, 1929; Brugger, 1930a; Smith, 1930; Luxemburg, 1931; Juda, 1934; Kreyenberg, 1935).

Type
Part II.—Original Articles
Information
Journal of Mental Science , Volume 85 , Issue 357 , July 1939 , pp. 719 - 762
Copyright
Copyright © Royal College of Psychiatrists, 1939 

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References

Bernstein, F.—“Variationen und Erblichkeitstatistik” in Handbuch der Vererbungwis-senschaft, Berlin, 1929.Google Scholar
Idem. —“Korrekturen bei erblichkeitsmatematischer Untersuchung von Krankheiten mit recessivem Erbgang,” Arch. Rassenbiol., 1933, xxvii, p. 25.Google Scholar
Brügger, C.—“Genealogische Untersuchungen an Schwachsinnigen,” Zeitschr. Neur. u. Psychiat., 1930a, cxxx, p. 66.Google Scholar
Idem. —“Die Stellung der Schwachsinnigen in der Geburtenheitenfolge,” ibid., 1930b, cxxxiii, p. 537.Google Scholar
Dahlberg, G.—Twin Births and Twins from a Hereditary Point of View, Stockhom, 1926.Google Scholar
Idem. —“Eine neue Methode zur familienstatistischen Analyse bei der Vererbungsforschung,” Hereditas, 1930a, xiv, p. 73.Google Scholar
Idem. —“Inzucht bei Polyhybridität beim Menschen,” ibid., 1930b, xiv, p. 83.Google Scholar
Fisher, R. A.—“The Detection of Linkage with Recessive Abnormalities,” Ann. Eugen., 1935, vi, p. 26.Google Scholar
Fölling, A.—“Ueber Ausscheidung von Phenylbrenztraubensäure in den Harn als Stoffwechselanomalie in Verbindung mit Imbezillität,” Zeitschr. Phys. Chem., 1934, ccxxvii, p. 169.CrossRefGoogle Scholar
Haldane, J. B. S.—“A Method for Investigating Recessive Characters in Man,” Journ. Genet., 1932, xxv, p. 251.CrossRefGoogle Scholar
Idem. —“Methods for the Detection of Autosomal Linkage in Man,” Ann. Eugen., 1934, vi, p. 26.Google Scholar
Idem. —“A Search for Incomplete Sex-linkage in Man,” ibid., 1936, vii, p. 28.Google Scholar
Idem. —“The Estimation of the Frequencies of Recessive Conditions in Man,” ibid., 1938a, viii, p. 255.Google Scholar
Idem. —In Perspectives of Biochemistry, Cambridge, 1938b.Google Scholar
Hogben, L.—“Genetic Analysis of Family Traits,” Journ. Genet., 1932, xxv, p. 211.Google Scholar
Hultkrantz, J., and Dahlberg, G.—“Die Verbreitung eines monohybriden Erbmerkmals in einer Population und in der Verwandtschaft von Merkmalsträger,” Arch. Rassenbiol., 1927, xix, p. 129.Google Scholar
Jervis, G. A.—“Phenylpyruvic Oligophrenia,” Arch. Neur. and Psychiat., 1937, xxxviii, p. 944.CrossRefGoogle Scholar
Johannsen, W.—Elemente der exakten Erblichkeitslehre, Jena, 1926.Google Scholar
Juda, A.—“Über Anzahl und psychische Beschaffenheit der Nachkommen von schwachsinnigen u. normalen Schülern,” Zeüschr. Neur. u. Psychiat., 1934, cli, p. 244.Google Scholar
Koller, P.—“On Pigment Formation in the D Black Rabbit,” Journ. Genet., 1930, xxii, p. 103.Google Scholar
Kreyenberg, E.—“Die Erblichkeitverhältnisse bei endogenem u. exogenem Schwachsinn,” Zeitschr. mensch. Vererbung u. Konstit., 1935, xix, p. 40.Google Scholar
Lenz, F.—“Die Bedeutung der statistisch ermittelten Belastung mit Blutverwandtschaft der Eltern,” Münch. med. Wochenschr., 1919, lxvi, p. 1340.Google Scholar
Idem. —“Erhalten die Begabten Familien Kaliforniens ihren Bestand?” Arch. Rassenbiol., 1925, xvii, p. 397.Google Scholar
Idem. —“Methoden der menschlichen Erblichkeitforschung” in Handbuch der hygienischen Untersuchungmethoden, Jena, 1929.Google Scholar
Lokay, A.—“Über die hereditären Beziehungen der Imbezillität,” Zeüschr. Neur. u. Psychiat., 1929, cxxii, p. 90.Google Scholar
Luxemburg, H.—“Zur Frage der Manifestationwahrscheinlichkeit der erblichen Schwachsinns,” ibid., 1931, cxxxv, p. 767.Google Scholar
Onslow, H.—“A Contribution to our Knowledge of the Chemistry of Coat Colour in Animals and of Dominant and Recessive Whiteness,” Proc. Roy. Soc. Lond., 1915, xiii, p. 189.Google Scholar
Penrose, L.—“On the Interaction of Heredity and Environment in the Study of Human Genetics, with Special Reference to Mongolian Idiocy,” Journ. Genet., 1932, xxv, p. 407.CrossRefGoogle Scholar
Idem. —The Influence of Heredity on Diseases, London, 1934.Google Scholar
Idem. —“Inheritance of Phenylpyruvic Amentia,” Lancet, 1935, ccxxix, p. 192.Google Scholar
Idem. —“Some Genetical Problems in Mental Deficiency,” Journ. Ment. Sci., 1938, lxxxiv, p. 693.Google Scholar
Rüdin, E.—Zur Vererbung und Neuenstehung der Dementia Prœcox, Berlin, 1916.Google Scholar
Schulz, B.—“Zur Genealogie des Mongolismus,” Zeitschr. Neur. u. Psychiat., 1931, cxxxiv, p. 268.Google Scholar
Sjögren, T.—“Die juvenile amaurotische Idiotie,” Hereditas, 1931, xiv, p. 197.Google Scholar
Idem. —“Klinische u. vererbungmedizinische Untersuchungen über Oligophrenia in einer Nordschwedische Bauernpopulation,” Acta Psychiat, 1932, Suppl. 2.Google Scholar
Idem. —“Investigations of the Heredity of Psychoses and Mental Deficiency in Two North Swedish Parishes,” Ann. Eugen., 1935, vi, p. 253.Google Scholar
Slome, D.—“The Genetic Basis of Amaurotic Family Idiocy,” Journ. Genet., 1934, xxvii, p. 363.Google Scholar
Smith, J. C.—“Das Ursachen-Verhältnis des Schwachsinns,” Zeüschr. Neur. u. Psychiat., 1930, cxxv, p. 678.Google Scholar
Weinberg, W.—Die Kinder der Tuberkulösen, Leipzig, 1913.CrossRefGoogle Scholar
Idem. —“Methodologische Geschichtpunkte für die statischen Untersuchungen der Dementia Præcox,” Zeitschr. Neur. u. Psychiat., 1920, lix.Google Scholar
Idem. —In Handbuch der sozialen Hygiene und Gesundheitfürsorge, Berlin, 1925.Google Scholar
Idem. —“Zur Probandenmethode,” Arch. Rassenbiol., 1931, xxiii, p. 281.Google Scholar
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