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Synthesis of novel core–shell structural AuNR@MCM-41 for infrared light-driven release of drug

Published online by Cambridge University Press:  15 September 2011

Liping Xie ,
Biao Dong ,
Zhenlong Jiang ,
Yu Wang ,
Tong Liu  and
Xue Bai
Liping Xie
Affiliation:
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People’s Republic of China
Biao Dong*
Affiliation:
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People’s Republic of China
Zhenlong Jiang
Affiliation:
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People’s Republic of China
Yu Wang
Affiliation:
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People’s Republic of China
Tong Liu
Affiliation:
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People’s Republic of China
Xue Bai
Affiliation:
State Key Laboratory on Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, People’s Republic of China
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

The hexagonal mesoporous silica MCM-41 nanospheres with Au nanorods (AuNRs) as core have been synthesized via a modified Stöber method by a process of hydration and condensation of tetraethoxysilane in a water–ethanol mixture. The AuNR@MCM-41 nanocomposites combine the photothermal characteristic with the mesopore of MCM-41 in one body. We utilized these core–shell materials for ibuprofen encapsulation and release in the simulated body fluid (pH 7.4) for the first time. The results certificated AuNR@MCM-41 nanocomposites as novel dual-functional materials could realize the light-driven release of drug due to the photothermal effect of the AuNRs. Such novel nanomaterials offer a new way for cancer treatment which combine hyperthermia with the chemotherapeutic drugs by synergistic effect.

Keywords

BiomaterialCompositeCore/shell
Type
Articles
Information
Journal of Materials Research , Volume 26 , Issue 18 , 28 September 2011 , pp. 2414 - 2419
Copyright
Copyright © Materials Research Society 2011

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