Hostname: page-component-586b7cd67f-g8jcs Total loading time: 0 Render date: 2024-11-24T15:34:17.395Z Has data issue: false hasContentIssue false
  • English
  • Français

Synthesis of calcium carbonate capsules in water-in-oil-in-water double emulsions

Published online by Cambridge University Press:  31 January 2011

G.X. Wu ,
J. Ding  and
J.M. Xue
G.X. Wu
Affiliation:
Department of Materials Science and Engineering, National University of Singapore, Singapore, 117574
J. Ding
Affiliation:
Department of Materials Science and Engineering, National University of Singapore, Singapore, 117574
J.M. Xue*
Affiliation:
Department of Materials Science and Engineering, National University of Singapore, Singapore, 117574
*
a)Address all correspondence to this author. e-mail: [email protected]
Get access

Abstract

Hollow capsules have been intensively investigated due to their high capacity of encapsulating large quantities of guest molecules, making them promising candidate materials for various encapsulation applications. In this work, CaCO3 hollow capsules were successfully synthesized via an emulsion route. The interior hollow structure of the capsules was confirmed by using scanning electron microscopy and transmission electron microscopy (TEM). The vaterite polymorph of the as-synthesized CaCO3 capsules was determined by using x-ray diffraction, high-resolution TEM, and Fourier transform infrared spectroscopy. A self-assembly model was proposed to explain the formation mechanism of the vaterite capsules. By adjusting experimental parameters such as the internal solution amount and the surfactant amount of the double-emulsion system, the average capsule size could be adjusted accordingly. However, the increase in capsule size was at a compensation of size-uniformity degradation. The capsule size uniformity was then further optimized by increasing the magnetic stirring rate. The resultant vaterite capsules demonstrated biodegradability behavior after immersion in phosphate-buffered saline solution, leading to their promising applications in the area of controlled drug delivery.

Keywords

BiomaterialCeramicCore/shell
Type
Articles
Information
Journal of Materials Research , Volume 23 , Issue 1 , January 2008 , pp. 140 - 149
Copyright
Copyright © Materials Research Society 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1Mann, S.Ozin, G.A.: Synthesis of inorganic materials with complex form. Nature 382, 313 1996CrossRefGoogle Scholar
2Kulak, A., Hall, S.R.Mann, S.: Single-step fabrication of drug-encapsulated inorganic microspheres with complex form by sonication-induced nanoparticle assembly. Chem. Commun. 5, 576 2004CrossRefGoogle Scholar
3Caruso, F., Caruso, R.A.Möhwald, H.: Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating. Science 282, 1111 1998CrossRefGoogle ScholarPubMed
4Chen, C.C., Liu, Y.C., Wu, C.H., Yeh, C.C., Su, M.T.Wu, Y.C.: Preparation of fluorescent silica nanotubes and their application in gene delivery. Adv. Mater. 17, 404 2005CrossRefGoogle Scholar
5Kam, N.W.S., Jessop, T.C., Wender, P.A.Dai, H.: Nanotube molecular transporters: Internalization of carbon nanotube-protein conjugates into mammalian cells. J. Am. Chem. Soc. 126, 6850 2004CrossRefGoogle Scholar
6Thomas, M.Klibanov, A.M.: Conjugation to gold nanoparticles enhances polyethylenimine’s transfer of plasmid DNA into mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 100, 9138 2003CrossRefGoogle ScholarPubMed
7Yamada, T., Iwasaki, Y.Tada, H.: Nanoparticles for the delivery of genes and drugs to human hepatocytes. Nat. Biotechnol. 21, 885 2003CrossRefGoogle ScholarPubMed
8Zhong, Z.Y., Yin, Y.D., Gates, D.Xia, Y.N.: Preparation of mesoscale hollow spheres of TiO2 and SnO2 by templating against crystalline arrays of polystyrene beads. Adv. Mater. 12, 206 20003.0.CO;2-5>CrossRefGoogle Scholar
9Chen, J.F., Wang, J.X.Liu, R.J.: Synthesis of porous silica structures with hollow interiors by templating nanosized calcium carbonate. Inorg. Chem. Commun. 7, 447 2004CrossRefGoogle Scholar
10Mandal, S.Krishnan, K.M.: CocoreAushell nanoparticles: Evolution of magnetic properties in the displacement reaction. J. Mat. Chem. 17, 372 2007CrossRefGoogle Scholar
11Dinsmore, A.D., Hsu, M.F., Nikolaides, M.G., Marquez, M., Bausch, A.R.Weitz, D.A.: Colloidosomes: Selectively permeable capsules composed of colloidal particles. Science 298, 1006 2002CrossRefGoogle ScholarPubMed
12Caruso, F., Shi, X.Y.Caruso, R.A.: Hollow titania spheres from layered precursor deposition on sacrificial colloidal core particles. Adv. Mater. 13, 740 20013.0.CO;2-6>CrossRefGoogle Scholar
13Sun, Y.Xia, Y.N.: Shape-controlled synthesis of gold and silver nanoparticles. Science 298, 2716 2002CrossRefGoogle ScholarPubMed
14Templeton, A.C., Wuelfing, W.P.Murray, R.W.: Monolayer protected cluster molecules. Acc. Chem. Res. 33, 27 2000CrossRefGoogle ScholarPubMed
15Collins, A.M., Spickermann, C.Mann, S.: Synthesis of titania hollow microspheres using non-aqueous emulsions. J. Math. Chem. 13, 1112 2003CrossRefGoogle Scholar
16Blin, J.L., Leonard, A., Yuan, Z.Y., Gigot, L., Vantomme, A., Cheetham, A.K.Su, B.L.: Hierarchically mesoporous/macroporous metal oxides templated from polyethylene oxide surfactant assemblies. Angew. Chem., Int. Ed. Engl. 42, 2872 2003CrossRefGoogle ScholarPubMed
17Yuan, Z.Y., Ren, T.Z.Su, B.L.: Hierarchically mesostructured titania materials with an unusual interior macroporous structure. Adv. Mater. 15, 1462 2003CrossRefGoogle Scholar
18Peng, Q., Dong, Y.Li, Y.: ZnSe semiconductor hollow microspheres. Angew. Chem., Int. Ed. Engl. 42, 3027 2003CrossRefGoogle ScholarPubMed
19Yang, Y.H.Gao, M.Y.: Preparation of fluorescent SiO2 particles with single CdTe nanocrystal cores by the reverse microemulsion method. Adv. Mater. 17, 2354 2005CrossRefGoogle Scholar
20Walsh, D., Lebeau, B.Mann, S.: Morphosynthesis of calcium carbonate (vaterite) microsponges. Adv. Mater. 11, 324 19993.0.CO;2-A>CrossRefGoogle Scholar
21Hirai, T., Harguchi, S., Komasawa, I.Davey, R.J.: Biomimetic synthesis of calcium carbonate particles in a pseudovesicular double emulsion. Langmuir 13, 6650 1997CrossRefGoogle Scholar
22Hirai, T., Hodono, M.Komasawa, I.: The preparation of spherical calcium phosphate fine particles using an emulsion liquid membrane system. Langmuir 16, 955 2000CrossRefGoogle Scholar
23Thomas, J.A., Seton, L., Davey, R.J.DeWolf, C.E.: Using a liquid emulsion membrane system for the encapsulation of organic and inorganic substrates within inorganic microcapsules. Chem. Commun. 10, 1072 2002CrossRefGoogle Scholar
24 JCPDS No. 33-0268. International Center for Diffraction Data: Newton Square, PA, 1966Google Scholar
25Andersen, F.A.Brecevic, L.: Infrared-spectra of amorphous and crystalline calcium carbonate. Acta Chem. Scand. A 45, 1018 1991CrossRefGoogle Scholar
26Raz, S., Weiner, S.Addadi, L.: Formation of high-magnesian calcites via an amorphous precursor phase: Possible biological implications. Adv. Mater. 12, 38 20003.0.CO;2-I>CrossRefGoogle Scholar
27Walker, J.B.A., Heywood, R.Mann, S.: Oriented nucleation of CaCO3 from metastable solutions under Langmuir monolayers. J. Mater. Chem. 1, 889 1991CrossRefGoogle Scholar
28Yu, S.H., Colfen, H., Hartmann, J.Antonietti, M.: Biomimetic crystallization of calcium carbonate spherules with controlled surface structures and sizes by double-hydrophilic block copolymers. Adv. Funct. Mater. 12, 541 20023.0.CO;2-3>CrossRefGoogle Scholar
29Rautaray, D., Sinha, K., Shankar, S.S., Adyanthaya, S.D.Sastry, M.: Aqueous foams as templates for the synthesis of calcite crystal assemblies of spherical morphology. Chem. Mater. 16, 1356 2004CrossRefGoogle Scholar