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Preparation of chitosan/safflower and ligusticum wallichii polysaccharides hydrogel for potential application in drug delivery and tissue engineering

Published online by Cambridge University Press:  11 July 2017

Xiuying Pu ,
Xiaoyue Li ,
Weijie Zhang ,
Xiaochun Wang ,
Haibing Li ,
Haowen Li  and
Wenjun Xu
Xiuying Pu
Affiliation:
School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou City, Gansu 730050, China
Xiaoyue Li
Affiliation:
School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou City, Gansu 730050, China
Weijie Zhang*
Affiliation:
School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou City, Gansu 730050, China
Xiaochun Wang
Affiliation:
School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou City, Gansu 730050, China
Haibing Li
Affiliation:
School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou City, Gansu 730050, China
Haowen Li
Affiliation:
School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou City, Gansu 730050, China
Wenjun Xu
Affiliation:
School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou City, Gansu 730050, China
*
a) Address all correspondence to this author. e-mail: [email protected]
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Abstract

Biological hydrogel is important in drug delivery system and tissue engineering. In this paper, we prepared a series of biological hydrogels with N,O-carboxymethyl chitosan (CS) and oxidized safflower and ligusticum wallichii polysaccharide-II (oxidized SLWP-II). Morphological analysis indicated the N,O-carboxymethyl CS/oxidized SLWP-II hydrogels (CSLHs) had porous interior structures, pore diameter ranged from tens to hundreds of micrometers. In vitro release test showed, with proportion of N,O-carboxymethyl CS to oxidized SLWP increasing from 1:1 to 1:3, cumulative release of bovine serum albumin decreased from 99 to 82%. In vitro cytotoxicity study showed that the developed hydrogels were not cytotoxic during one week of culturing with WI-38 cells, and they have a role in promoting cell proliferation. So the N,O-carboxymethyl CS/oxidized safflower and ligusticum wallichii polysaccharide-II hydrogels might have potential application in the drug delivery system and tissue engineering.

Keywords

hydrogelcross-linkN,O-carboxymethyl CSoxidized SLWP-IIcytocompatibility
Type
Articles
Information
Journal of Materials Research , Volume 32 , Issue 14 , 28 July 2017 , pp. 2719 - 2727
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Copyright
Copyright © Materials Research Society 2017 

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Footnotes

Contributing Editor: Susmita Bose

References

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