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Fabrication and characterization of superelastic Ti–Nb alloy enhanced with antimicrobial Cu via spark plasma sintering for biomedical applications

Published online by Cambridge University Press:  29 May 2017

Yuanhuai He ,
Yuqin Zhang ,
Yehua Jiang  and
Rong Zhou
Yuanhuai He*
Affiliation:
School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China
Yuqin Zhang*
Affiliation:
School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China; and Engineering Technology Research Center of Titanium Products and Application of Yunnan Province, Kunming 650093, China
Yehua Jiang
Affiliation:
School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China
Rong Zhou
Affiliation:
School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China
*
a) Address all correspondence to this author. e-mail: [email protected]
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Abstract

A superelastic Ti–40Nb alloy enhanced with Cu element (0, 2.5, 5, 7.5, and 10 wt%) was synthesized by a spark plasma sintering method to obtain biomaterials with an antimicrobial effect. The microstructure results showed that β phase was the main phase in (Ti–40Nb)–Cu alloys while Ti2Cu was synthesized with the Cu addition above 5 wt%. (Ti–40Nb)–Cu alloys exhibited high compressive strength over 1693.08 MPa, high yield strength of 1140.26–1619.14 MPa, low elastic modulus in the range of 43.91–58.01 GPa, low elastic energy (14.81–24.73 MJ/m3), and together with large plastic strain over 18.5%. High concentration of Cu ion released steadily from alloys in early 7 days, then the released concentration of Cu ion showed long-lasting and moderate. Comparing with the Ti–40Nb alloy, high antimicrobial activity was pronounced on (Ti–40Nb)–Cu alloys, and (Ti–40Nb)–Cu alloys showed more inhibitory activity against bacteria (E. coli and S. aureus) than fungi (C. albicans). Cu contents in alloys influenced the Cu ion release, which in turn affected the antimicrobial activity. As a good combination of low elastic modulus, high mechanical properties, good elastic energy, and excellent antimicrobial performance, (Ti–40Nb)–Cu alloys offer potential advantages to prevent stress shielding and exhibit an excellent antimicrobial property for hard tissue replacements.

Keywords

Ti–Nb–Cu alloyspark plasma sinteringmicrostructuremechanical propertiesantibacterial activity
Type
Articles
Information
Journal of Materials Research , Volume 32 , Issue 13 , 14 July 2017 , pp. 2510 - 2520
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Copyright
Copyright © Materials Research Society 2017 

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Footnotes

Contributing Editor: Terry M. Tritt

References

REFERENCES

Chen, Q.Z. and Thouas, G.A.: Metallic implant biomaterials. Mater. Sci. Eng., R 87, 1–57 (2015).Google Scholar
Hao, Y.L., Li, S.J., Sun, S.Y., Zheng, C.Y., and Yang, R.: Elastic deformation behaviour of Ti–24Nb–4Zr–7.9Sn for biomedical applications. Acta Biomater. 3, 277–286 (2007).Google Scholar
Baker, H., Okamoto, H., and Henry, S.D.: ASM Handbook: Alloy Phase Diagrams, Vol. 3 (ASM International Materials Park, Ohio, 1992).Google Scholar
Fu, J., Yamamoto, A., Kim, H.Y., Hosoda, H., and Miyazaki, S.: Novel Ti-base superelastic alloys with large recovery strain and excellent biocompatibility. Acta Biomater. 17, 56–67 (2015).Google Scholar
Miyazaki, S., Kim, H.Y., and Hosoda, H.: Development and characterization of Ni-free Ti-base shape memory and superelastic alloys. Mater. Sci. Eng., A 438, 18–24 (2006).Google Scholar
Harris, W.H. and Sledge, C.B.: Total hip and total knee replacement. N. Engl. J. Med. 323, 725–731 (1990).Google Scholar
Heidenau, F., Mittelmeier, W., Detsch, R., Haenle, M., Stenzel, F., Ziegler, G., and Gollwitzer, H.A.: A novel antibacterial titania coating: Metal ion toxicity and in vitro surface colonization. J. Mater. Sci.: Mater. Med. 16, 883–888 (2005).Google Scholar
Waizy, H., Seitz, J.M., Reifenrath, J., Weizbauer, A., Bach, F.W., Meyer-Lindenberg, A., Denkena, B., and Windhagen, H.: Biodegradable magnesium implants for orthopedic applications. J. Mater. Sci. 48, 39–50 (2013).Google Scholar
Ding, Y.F., Wen, C., Hodgson, P., and Li, Y.: Effects of alloying elements on the corrosion behavior and biocompatibility of biodegradable magnesium alloys: A review. J. Mater. Chem. B 2, 1912–1933 (2014).Google Scholar
Abdelmageed, A.B. and Oehme, F.W.: A review on biochemical roles, toxicity and interactions of zinc, copper and iron: IV. Interactions. Vet. Hum. Toxicol. 32, 456–458 (1990).Google Scholar
Morakabati, M., Kheirandish, S., Aboutalebi, M., Taheri, A.K., and Abbasi, S.M.: The effect of Cu addition on the hot deformation behavior of NiTi shape memory alloys. J. Alloys Compd. 499, 57–62 (2010).Google Scholar
Zhang, E., Zheng, L., Liu, J., Bai, B., and Liu, C.: Influence of Cu content on the cell biocompatibility of Ti–Cu sintered alloys. Mater. Sci. Eng., C 46, 148–157 (2015).Google Scholar
Zhang, E., Li, F., Wang, H., Liu, J., Wang, C., and Li, M.: A new antibacterial titanium–copper sintered alloy: Preparation and antibacterial property. Mater. Sci. Eng., C 33, 4280–4287 (2013).Google Scholar
Holden, F.C., Watts, A.A., Ogden, H.R., and Jaffee, R.I.: Heat treatment and mechanical properties of Ti–Cu alloys. Trans. AIME 7, 117–125 (1955).Google Scholar
Ren, G., Hu, D., Cheng, E.W.C., Vargas-Reus, M.A., Reip, P., and Allaker, R.P.: Characterisation of copper oxide nanoparticles for antimicrobial applications. Int. J. Antimicrob. Agents 33, 587–590 (2009).Google Scholar
Calin, M., Helth, A., Gutierrez, J.J., Bönisch, M., Brackmann, V., and Giebeler, L.: Elastic softening of beta-type Ti–Nb alloys by indium (In) additions. J. Mech. Behav. Biomed. Mater. 39, 162–174 (2014).Google Scholar
Farooq, M.U., Khalid, F.A., Zaigham, H., and Abidi, I.H.: Superelastic behaviour of Ti–Nb–Al ternary shape memory alloys for biomedical applications. Mater. Lett. 121, 58–61 (2014).Google Scholar
Lee, C.M., Ju, C.P., and Chern-Lin, J.H.: Structure–property relationship of cast Ti–Nb alloys. J. Oral Rehabil. 29, 314–322 (2002).Google Scholar
Murray, J.L. and Baker, H.: Alloy Phase Diagrams (ASM International, Metals Park, Ohio, 1987); p. 180.Google Scholar
Otsuka, K. and Wayman, C.M.: Shape Memory Materials, 1st ed. (Cambridge University Press, Cambridge, 1999).Google Scholar
Hayama, A.O.F., Andrade, P.N., Cremasco, A., Contieri, R.J., Afonso, C.R.M., and Caram, R.: Effects of composition and heat treatment on the mechanical behavior of Ti–Cu alloys. Mater. Des. 55, 1006–1013 (2014).Google Scholar
Lee, H.J. and Aaronson, H.I.: Eutectoid decomposition mechanisms in hypoeutectoid Ti–X alloys. J. Mater. Sci. 23, 150–160 (1988).Google Scholar
Zhang, D.C., Mao, Y.F., Li, Y.L., Li, J.J., Yuan, M., and Lin, J.G.: Effect of ternary alloying elements on microstructure and superelasticity of Ti–Nb alloys. Mater. Sci. Eng., A 559, 706–710 (2013).Google Scholar
Hon, Y.H., Wang, J.Y., and Pan, Y.N.: Influence of hafnium content on mechanical behaviors of Ti–40Nb–xHf alloys. Mater. Lett. 58, 3182–3186 (2004).Google Scholar
Graft, W.H., Levinson, D.W., and Rostoker, W.: The influence of alloying on the elastic modulus of titanium alloys. ASM Trans. 49, 263–279 (1957).Google Scholar
Fleischer, R.L., Gilmore, R.S., and Zabala, R.J.: Elastic moduli of polycrystalline, intermetallic compounds of titanium. J. Appl. Phys. 64, 2964–2967 (1988).Google Scholar
Yao, X., Sun, Q.Y., Xiao, L., and Sun, J.: Effect of Ti2Cu precipitates on mechanical behavior of Ti–2.5Cu alloy subjected to different heat treatments. J. Alloys Compd. 484, 196–202 (2009).Google Scholar
Ozan, S., Lin, J., Li, Y., Ipek, R., and Wen, C.: Development of Ti–Nb–Zr alloys with high elastic admissible strain for temporary orthopedic devices. Acta Biomater. 20, 176–187 (2015).Google Scholar
Zhan, Y., Li, C., and Jiang, W.: β-type Ti–10Mo–1.25Si–xZr biomaterials for applications in hard tissue replacements. Mater. Sci. Eng., C 32, 1664–1668 (2012).Google Scholar
Stranak, V., Wulff, H., Ksirova, P., Zietz, C., and Drache, S.: Ionized vapor deposition of antimicrobial Ti–Cu films with controlled copper release. Thin Solid Films 550, 389–394 (2014).Google Scholar
World Health Organization: Trace Elements in Human Nutrition and Health (WHO, Geneva, 1996).Google Scholar
Shirai, T., Tsuchiya, H., Shimizu, T., Ohtani, K., Zen, Y., and Tomita, K.: Prevention of pin tract infection with titanium–copper alloys. J. Biomed. Mater. Res., Part B 91, 373–380 (2009).Google Scholar
Liu, J., Li, F., Liu, C., Wang, H., Ren, B., Yang, K., and Zhang, E.: Effect of Cu content on antibacterial activity of titanium–copper sintered alloys. Mater. Sci. Eng., C 35, 392–400 (2014).Google Scholar
Horton, D.J., Ha, H., Foster, L.L., Bindig, H.J., and Scully, J.R.: Tarnishing and Cu ion release in selected copper-base alloys: Implications towards antimicrobial functionality. Electrochim. Acta 169, 351–366 (2015).Google Scholar
Thurman, R.B. and Gerba, C.P.: The molecular mechanisms of copper and silver ion disinfection of bacteria and viruses. CRC Crit. Rev. Environ. Control 18, 295–315 (1989).Google Scholar
Samuni, A., Chevion, M., and Czapski, G.: Roles of copper and superoxide anion radicals in the radiation-induced inactivation of T7 bacteriophage. Radiat. Res. 99, 562–572 (1984).Google Scholar
Yamamoto, A., Honma, R., and Sumita, M.: Cytotoxicity evaluation of 43 metal salts using murine fibroblasts and osteoblastic cells. J. Biomed. Mater. Res. 39, 331–340 (1998).Google Scholar