Hostname: page-component-cd9895bd7-jn8rn Total loading time: 0 Render date: 2024-12-26T07:05:16.103Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of biomimetic micropattern on titanium deposited with PDA/Cu and nitric oxide release on behaviors of ECs

Published online by Cambridge University Press:  20 May 2019

Wenyong Ma Open the ORCID record for Wenyong Ma [Opens in a new window] ,
Luying Liu ,
Xiao luo ,
Congzhen Han ,
Ping Yang ,
Yuancong Zhao  and
Nan Huang
Wenyong Ma
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China; and Material Technology Insitution, Yibin University, Yibin 644000, People’s Republic of China
Luying Liu
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China
Xiao luo
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China
Congzhen Han
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China
Ping Yang*
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China
Yuancong Zhao*
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China
Nan Huang
Affiliation:
Key Laboratory of Advanced Technology of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China
*
a)Address all correspondence to these authors. e-mail: [email protected]
b)e-mail: [email protected]
Get access

Abstract

Surface modification with poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC) is an effective method for improving hemocompatibility. Peptide GREDVY immobilized on Ti is of great benefit to endothelialization. Micropattern of PMPC and GREDVY can regulate cells distribution, behaviors, and nitric oxide (NO) release. Copper can be used as catalytic to release NO from a donor in vitro, which can inhibit platelets adhesion, activation, and aggregation. The Ti-PDA(Cu)-M/R(P) micropattern was fabricated with PMMPC-HD {PMMPC [monomer contain MPC and methacrylic acid (MA)] was cross-linked with hexamethylene diamine} and peptide Gly-Arg-Glu-Asp-Val-Tyr (GREDVY) using PDMS stamp, and it was characterized by SEM, FTIR, and XPS. The results demonstrated that the PMPC and peptide GREDVY were immobilized onto polydopamine successfully. Simultaneously, the copper existed in polydopamine was confirmed by XPS. The rate of NO release in vitro catalyzed by copper ions was 1.5–5.3 × 10−10 mol/(cm2 min). It will be beneficial to inhibiting platelets adhesion and proliferation of ECs.

Keywords

nitric oxidemicropatternECMPCGREDVY
Type
Article
Information
Journal of Materials Research , Volume 34 , Issue 12 , 28 June 2019 , pp. 2037 - 2046
Copyright
Copyright © Materials Research Society 2019 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Williams, D.F.: On the mechanisms of biocompatibility. Biomaterials 29, 2941 (2008).CrossRefGoogle ScholarPubMed
Li, G., Yang, P., Qin, W., Maitz, M.F., Zhou, S., and Huang, N.: The effect of coimmobilizing heparin and fibronectin on titanium on hemocompatibility and endothelialization. Biomaterials 32, 4691 (2011).CrossRefGoogle ScholarPubMed
Tousoulis, D., Kampoli, A.M., Tentolouris, C., Papageorgiou, N., and Stefanadis, C.: The role of nitric oxide on endothelial function. Curr. Vasc. Pharmacol. 10, 4 (2012).CrossRefGoogle ScholarPubMed
Lei, J., Vodovotz, Y., Tzeng, E., and Billiar, T.R.: Nitric oxide, a protective molecule in the cardiovascular system. Nitric Oxide 35, 175 (2013).CrossRefGoogle ScholarPubMed
Naghavi, N., De, M.A., Alavijeh, O.S., Cousins, B.G., and Seifalian, A.M.: Nitric oxide donors for cardiovascular implant applications. Small 9, 22 (2013).CrossRefGoogle ScholarPubMed
de Mel, A., Murad, F., and Seifalian, A.M.: Nitric oxide: A guardian for vascular grafts? Chem. Rev. 111, 5742 (2011).CrossRefGoogle ScholarPubMed
Taite, L.J., Yang, P., Jun, H.W., and West, J.L.: Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion. J. Biomed. Mater. Res., Part B 84, 108 (2008).CrossRefGoogle ScholarPubMed
Li, X., Qiu, H., Gao, P., Yang, Y., Yang, Z., and Huang, N.: Synergetic coordination and catecholamine chemistry for catalytic generation of nitric oxide on vascular stents. NPG Asia Mater. 10, 482 (2018).CrossRefGoogle Scholar
Hwang, S., Cha, W., and Meyerhoff, M.E.: Polymethacrylates with a covalently linked CuII–cyclen complex for the in situ generation of nitric oxide from nitrosothiols in blood. Angew. Chem., Int. Ed. 118, 2811 (2006).CrossRefGoogle Scholar
Yang, Z., Yang, Y., Xiong, K., Li, X., Qi, P., Tu, Q., Jing, F., Weng, Y., Wang, J., and Huang, N.: Nitric oxide producing coating mimicking endothelium function for multifunctional vascular stents. Biomaterials 63, 80 (2015).10.1016/j.biomaterials.2015.06.016CrossRefGoogle ScholarPubMed
Zorlutuna, P., Annabi, N., Camci-Unal, G., Nikkhah, M., Cha, J.M., Nichol, J.W., Manbachi, A., Bae, H., Chen, S., and Khademhosseini, A.: Microfabricated biomaterials for engineering 3D tissues. Adv. Mater. 24, 1782 (2012).10.1002/adma.201104631CrossRefGoogle ScholarPubMed
Zhang, F., Li, G., Yang, P., Qin, W., Li, C., and Huang, N.: Fabrication of biomolecule-PEG micropattern on titanium surface and its effects on platelet adhesion. Colloids Surf., B 102, 457 (2013).CrossRefGoogle ScholarPubMed
Chen, J., Ge, J., Guo, B., Gao, K., and Ma, P.X.: Nanofibrous polylactide composite scaffolds with electroactivity and sustained release capacity for tissue engineering. J. Mater. Chem. B 4, 2477 (2016).CrossRefGoogle Scholar
Wang, L., Wu, Y., Guo, B., and Ma, P.X.: Nanofiber yarn/hydrogel core–shell scaffolds mimicking native skeletal muscle tissue for guiding 3D myoblast alignment, elongation, and differentiation. ACS Nano 9, 9167 (2015).CrossRefGoogle Scholar
Wu, Y., Wang, L., Guo, B., and Ma, P.X.: Interwoven aligned conductive nanofiber yarn/hydrogel composite scaffolds for engineered 3D cardiac anisotropy. ACS Nano 11, 5646 (2017).CrossRefGoogle ScholarPubMed
Wu, Y., Wang, L., Hu, T., Ma, P.X., and Guo, B.: Conductive micropatterned polyurethane films as tissue engineering scaffolds for Schwann cells and PC12 cells. J. Colloid Interface Sci. 518, 252 (2018).CrossRefGoogle ScholarPubMed
Nikkhah, M., Eshak, N., Zorlutuna, P., Annabi, N., Castello, M., Kim, K., Dolatshahi-Pirouz, A., Edalat, F., Bae, H., and Yang, Y.: Directed endothelial cell morphogenesis in micropatterned gelatin methacrylate hydrogels. Biomaterials 33, 9009 (2012).CrossRefGoogle ScholarPubMed
Versaevel, M., Grevesse, T., and Gabriele, S.: Spatial coordination between cell and nuclear shape within micropatterned endothelial cells. Nat. Commun. 3, 671 (2012).CrossRefGoogle ScholarPubMed
Liu, Y., Ai, K., and Lu, L.: Polydopamine and its derivative materials: Synthesis and promising applications in energy, environmental, and biomedical fields. Chem. Rev. 114, 5057 (2014).CrossRefGoogle ScholarPubMed
Lee, H., Dellatore, S.M., Miller, W.M., and Messersmith, P.B.: Mussel-inspired surface chemistry for multifunctional coatings. Science 318, 426 (2007).10.1126/science.1147241CrossRefGoogle ScholarPubMed
Ren, H., Wu, J., Xi, C., Lehnert, N., Major, T., Bartlett, R.H., and Meyerhoff, M.E.: Electrochemically modulated nitric oxide (NO) releasing biomedical devices via copper(II)-Tri(2-pyridylmethyl)amine mediated reduction of nitrite. ACS Appl. Mater. Interfaces 6, 3779 (2014).10.1021/am406066aCrossRefGoogle ScholarPubMed
Pant, J., Goudie, M.J., Hopkins, S.P., Brisbois, E.J., and Handa, H.: Tunable nitric oxide release from S-nitroso-N-acetylpenicillamine via catalytic copper nanoparticles for biomedical applications. ACS Appl. Mater. Interfaces 9, 15254 (2017).CrossRefGoogle ScholarPubMed
Harding, J.L.: Composite materials with embedded metal organic framework catalysts for nitric oxide release from bioavailable S-nitrosothiols. J. Mater. Chem. B 2, 2530 (2014).10.1039/C3TB21458CCrossRefGoogle Scholar
Wonoputri, V., Gunawan, C., Liu, S., Barraud, N., Yee, L.H., Lim, M., and Amal, R.: Copper complex in poly(vinyl chloride) as a nitric oxide-generating catalyst for the control of nitrifying bacterial biofilms. ACS Appl. Mater. Interfaces 7, 22148 (2015).CrossRefGoogle ScholarPubMed
Jia, Z., Li, H., Zhao, Y., Frazer, L., Qian, B., Borguet, E., Ren, F., and Dikin, D.A.: Electrical and mechanical properties of poly(dopamine)-modified copper/reduced graphene oxide composites. J. Mater. Sci. 52, 11620 (2017).CrossRefGoogle Scholar
Lee, H., Rho, J., and Messersmith, P.B.: Facile conjugation of biomolecules onto surfaces via mussel adhesive protein inspired coatings. Adv. Mater. 21, 431 (2009).CrossRefGoogle ScholarPubMed
Yang, Z.L., Zhong, S., Yang, Y., Maitz, M.F., Li, X., Tu, Q.F., Qi, P., Zhang, H., Qiu, H., and Wang, J.: Polydopamine-mediated long-term elution of the direct thrombin inhibitor bivalirudin from TiO2 nanotubes for improved vascular biocompatibility. J. Mater. Chem. B 2, 6767 (2014).CrossRefGoogle Scholar
Yang, Y., Li, X., Qiu, H., Li, P., Qi, P., Maitz, M.F., You, T., Shen, R., Yang, Z., Tian, W., and Huang, N.: Polydopamine modified TiO2 nanotube arrays for long-term controlled elution of bivalirudin and improved hemocompatibility. ACS Appl. Mater. Interfaces 10, 7649 (2018).CrossRefGoogle ScholarPubMed
Park, J., Brust, T.F., Lee, H.J., Lee, S.C., Watts, V.J., and Yeo, Y.: Polydopamine-based simple and versatile surface modification of polymeric nano drug carriers. ACS Nano 8, 3347 (2014).CrossRefGoogle ScholarPubMed
Ma, W., Liu, L., Chen, H., Zhao, Y., Yang, P., and Huang, N.: Micropatterned immobilization of membrane-mimicking polymer and peptides for regulation of cell behaviors in vitro. RSC Adv. 8, 20836 (2018).10.1039/C8RA02607FCrossRefGoogle Scholar
Wei, Y., Ji, Y., Xiao, L.L., Lin, Q.K., Xu, J.P., Ren, K.F., and Ji, J.: Surface engineering of cardiovascular stent with endothelial cell selectivity for in vivo re-endothelialisation. Biomaterials 34, 2588 (2013).CrossRefGoogle ScholarPubMed
Liu, Y., Yang Tan, T.T., Yuan, S., and Choong, C.: Multifunctional P(PEGMA)–REDV conjugated titanium surfaces for improved endothelial cell selectivity and hemocompatibility. J. Mater. Chem. B 1, 157 (2013).CrossRefGoogle Scholar
Massia, S.P. and Hubbell, J.A.: Vascular endothelial cell adhesion and spreading promoted by the peptide REDV of the IIICS region of plasma fibronectin is mediated by integrin alpha 4 beta 1. J. Biol. Chem. 267, 14019 (1992).Google ScholarPubMed
Hahn, M.S., Taite, L.J., Moon, J.J., Rowland, M.C., Ruffino, K.A., and West, J.L.: Photolithographic patterning of polyethylene glycol hydrogels. Biomaterials 27, 2519 (2006).CrossRefGoogle ScholarPubMed
Hubbell, J.A., Massia, S.P., Desai, N.P., and Drumheller, P.D.: Endothelial cell-selective materials for tissue engineering in the vascular graft via a new receptor. Nat. Biotechnol. 9, 568 (1991).CrossRefGoogle Scholar
Chen, L., Li, J., Wang, S., Zhu, S., Zhu, C., Zheng, B., Yang, G., and Guan, S.: Surface modification of the biodegradable cardiovascular stent material Mg–Zn–Y–Nd alloy via conjugating REDV peptide for better endothelialization. J. Mater. Res. 33, 4123 (2018).CrossRefGoogle Scholar
Wu, J., Lin, W., Wang, Z., Chen, S., and Chang, Y.: Investigation of the hydration of nonfouling material poly(sulfobetaine methacrylate) by low-field nuclear magnetic resonance. Langmuir 28, 7436 (2012).CrossRefGoogle ScholarPubMed
Huang, Q., Yang, Y., Hu, R., Lin, C., Sun, L., and Vogler, E.A.: Reduced platelet adhesion and improved corrosion resistance of superhydrophobic TiO2-nanotube-coated 316L stainless steel. Colloids Surf., B 125, 134 (2015).CrossRefGoogle ScholarPubMed
Liu, X., Yuan, L., Li, D., Tang, Z., Wang, Y., Chen, G., Chen, H., and Brash, J.L.: Blood compatible materials: State of the art. J. Mater. Chem. B 2, 5718 (2014).CrossRefGoogle Scholar
Ma, W., Yang, P., Li, J., Li, S., Li, P., Zhao, Y., and Huang, N.: Immobilization of poly(MPC) brushes onto titanium surface by combining dopamine self-polymerization and ATRP: Preparation, characterization and evaluation of hemocompatibility in vitro. Appl. Surf. Sci. 349, 445 (2015).CrossRefGoogle Scholar
Chen, H., Li, X., Zhao, Y., Li, J., Chen, J., Yang, P., Maitz, M.F., and Huang, N.: Construction of a multifunctional coating consisting of phospholipids and endothelial progenitor cell-specific peptides on titanium substrates. Appl. Surf. Sci. 347, 169 (2015).CrossRefGoogle Scholar
Anderson, D.E.J. and Hinds, M.T.: Endothelial cell micropatterning: Methods, effects, and applications. Ann. Biomed. Eng. 39, 2329 (2011).CrossRefGoogle ScholarPubMed
Cha, W. and Meyerhoff, M.E.: Catalytic generation of nitric oxide from S-nitrosothiols using immobilized organoselenium species. Biomaterials 28, 19 (2007).CrossRefGoogle ScholarPubMed
Yang, Z., Lei, X., Wang, J., Luo, R., He, T., Sun, H., and Huang, N.: A novel technique toward bipolar films containing alternating nano-layers of allylamine and acrylic acid plasma polymers for biomedical application. Plasma Processes Polym. 8, 208 (2011).CrossRefGoogle Scholar