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Effect of surface properties of mesoporous silica on adsorption of mesoionic compound molsidomine

Published online by Cambridge University Press:  17 October 2012

N.A. Alyoshina  and
E.V. Parfenyuk
N.A. Alyoshina
Affiliation:
G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, Ivanovo, 153045, Russia
E.V. Parfenyuk*
Affiliation:
G.A. Krestov Institute of Solution Chemistry of Russian Academy of Sciences, Ivanovo, 153045, Russia
*
a)Address all correspondence to this author. e-mail: [email protected]
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Abstract

Molsidomine is one of the sydnonimine class of antianginal drugs that due to its structure exhibits both dipolar nature and aromatic properties. To select efficient carrier for the drug, unmodified and modified mesoporous silica materials were synthesized using phenyltriethoxysilane and 3-aminopropyltriethoxysilane via cocondensation and grafting routes. Synthesis of the mesoporous silica materials via cocondensation was carried out in the presence of D-glucose as pore-forming agent. Equilibrium isotherms for the adsorption of mesoionic compound molsidomine on the mesoporous silica materials were analyzed by the Langmuir, Freundlich, Redlich-Peterson and Langmuir–Freundlich (Sips) models. Langmuir model is found to be the best to explain the equilibrium data. Comparative study of the adsorption properties of the unmodified and modified mesoporous silica materials demonstrated that the phenyl-modified silica materials are the most efficient adsorbents for molsidomine. They exhibit the highest adsorption capacity and affinity in relation to the mesoionic compound.

Keywords

adsorptionsurface chemistrybiomaterial
Type
Articles
Information
Journal of Materials Research , Volume 27 , Issue 22 , 22 November 2012 , pp. 2858 - 2866
Copyright
Copyright © Materials Research Society 2012

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