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A targeted drug delivery system based on carbon nanotubes loaded with lobaplatin toward liver cancer cells

Published online by Cambridge University Press:  26 July 2018

Shiping Yu ,
Qiang Li ,
Junli Wang ,
Jinglei Du ,
Yuduan Gao ,
Li Zhang ,
Lin Chen ,
Yongzhen Yang  and
Xuguang Liu
Shiping Yu*
Affiliation:
Interventional Treatment Department, Second Hospital of Shanxi Medical University, Taiyuan 030001, China; and Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China
Qiang Li
Affiliation:
Interventional Treatment Department, Second Hospital of Shanxi Medical University, Taiyuan 030001, China
Junli Wang
Affiliation:
Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China; and Research Center on Advanced Materials Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China
Jinglei Du
Affiliation:
Interventional Treatment Department, Second Hospital of Shanxi Medical University, Taiyuan 030001, China
Yuduan Gao
Affiliation:
Ophthalmology Department, Shanxi Dayi Hospital, Taiyuan 030032, China
Li Zhang
Affiliation:
Urology Department, Shanxi Dayi Hospital, Taiyuan 030032, China
Lin Chen
Affiliation:
Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China; and Research Center on Advanced Materials Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China
Yongzhen Yang*
Affiliation:
Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China; and Research Center on Advanced Materials Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China
Xuguang Liu
Affiliation:
Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China
*
a)Address all correspondence to these authors. e-mail: [email protected]
b)e-mail: [email protected]
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Abstract

To eliminate the toxic effect of chemotherapy drug of lobaplatin (LBP) on body tissue in liver cancer therapy, this work prepared a nanodrug carrier based on polyethylene glycol-modified carbon nanotubes (PEG–CNTs) and then constructed a targeted drug delivery system (LBP–PEG–CNTs) by loading LBP on PEG–CNTs. Fluorescein isothiocyanate (FITC) was used to label PEG–CNTs to observe the cellular uptake of PEG–CNTs. In addition, the inhibitions of LBP–PEG–CNTs on HepG2 cells were investigated. The results show that the FITC-labeled PEG–CNTs have good cell penetrability; meanwhile, LBP–PEG–CNTs have good stability, pH-controlled release property, and high inhibition rate on HepG2 cells. To be specific, 80% of LBP is released under physiological conditions of liver cancer cells at pH 5.0, and LBP–PEG–CNTs show a high inhibition rate of 77.86% on HepG2 cells, demonstrating that they have targeted, pH-controlled release and inhibition properties on HepG2 cells.

Keywords

carbon nanotubeslobaplatinliver cancer cellanticancertarget
Type
Article
Information
Journal of Materials Research , Volume 33 , Issue 17 , 14 September 2018 , pp. 2565 - 2575
Copyright
Copyright © Materials Research Society 2018 

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